Varios autores - Cardiología y enfermedades cardiovasculares

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Cristhian Felipe Ramírez Ramos

Clara Inés Saldarriaga Giraldo

Resumen

La importancia clínica de la falla cardiaca con fracción de eyección preservada del ventrículo izquierdo (FCFep) es cada vez mayor. Se espera que sea el fenotipo dominante de la enfermedad. La mejoría en el entendimiento de la enfermedad ha mostrado que es una afección heterogénea en la que se da una interrelación genética, enfermedades del estilo de vida y alta carga de trastornos crónicos. Esta enfermedad se caracteriza por disfunción diastólica, alteración de la compliance e hipocinesia con síntomas como disnea, intolerancia al ejercicio y fatiga. La mortalidad y la tasa de supervivencia acumulada son iguales que para los pacientes con falla cardiaca con fracción de eyección del ventrículo izquierdo (FEVI) reducida. Ningún agente terapéutico ha mostrado efectividad en este subtipo de pacientes, por lo que en la actualidad se investiga de manera activa para poder ofrecer medidas que modifiquen su curso.