Richard J. Miron - Understanding Platelet-Rich Fibrin

Understanding Platelet-Rich Fibrin

Library of Congress Cataloging-in-Publication Data

Names: Miron, Richard J. (Richard John), 1983- editor.

Title: Understanding platelet-rich fibrin / edited by Richard J. Miron.

Description: Batavia, IL : Quintessence Publishing Co Inc, [2021] | Includes bibliographical references and index. | Summary: "This book outlines the science behind platelet-rich fibrin and then details how to use it in clinical practice to optimize healing outcomes and promote tissue regeneration. Applications include gingival recessions, intrabony and furcation defects, extraction site management, implant dentistry, guided bone regeneration, sinus grafting, oral and maxillofacial surgery, regenerative endodontics, facial esthetics, and medicine"--Provided by publisher.

Identifiers: LCCN 2020035734 | ISBN 9781647240493 (hardcover)

Subjects: MESH: Platelet-Rich Fibrin | Fibrin--therapeutic use | Tissue Engineering | Bone Regeneration

Classification: LCC QP91 | NLM WH 400 | DDC 612.1/15--dc23

LC record available at https://lccn.loc.gov/2020035734

©2021 Quintessence Publishing Co, Inc

Quintessence Publishing Co, Inc

411 N Raddant Road

Batavia, IL 60510

www.quintpub.com

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All rights reserved. This book or any part thereof may not be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, or otherwise, without prior written permission of the publisher.

Editor: Leah Huffman

Design: Sue Zubek

Production: Angelina Schmelter

Printed in the USA

Contents

Dedication Dedication I would like to dedicate this textbook specifically to Dr Fatiha Chandad and the Dental Faculty at the University of Laval in Quebec, Canada, who devoted countless hours to training students like me in dentistry. Dr Chandad, Dean of Dental Research, was someone who motivated me and more importantly made it possible for students to work within her laboratory on research projects during their 4 years of dental studies. It was here that I first started my research activities on PRP/PRF and became fascinated with research as a whole. Dr Chandad is one of the only people I have ever met never wanting to be recognized for her achievements, instead insisting that her students be recognized and at the forefront of their own success. It was during these times that I was awarded the prestigious Hatton Award in Canada and was later named the IADR Young Investigator of the Year in Implant Dentistry. In appreciation of her contributions to my career, 100% of the royalties from this textbook will be donated to create a scholarship named after her for new dental graduates at the University of Laval. Milles fois merci pour tout tes efforts!

Foreword by Robert E. Marx Foreword Many important medical/dental discoveries were stumbled upon by pure chance. An example of this is osseointegration, which launched the modern era of dental implants and orthopedic-embedded prostheses. It occurred when orthopedic researcher Per-Ingvar Brånemark found that his titanium research cages in sheep were so completely ingrown with bone that he couldn’t remove them. Similarly, platelet-rich plasma (PRP)/platelet-rich fibrin (PRF) was discovered by the serendipity of observing accelerated and more complete healing in patients who developed hematomas. From that simple observation in the 1980s, the components of the blood clot responsible for the advanced healing have since been determined to be the complete and active growth factors in the alpha granules of viable platelets and several cell adhesion molecules and homing signals in the fibrin clot. From the early pioneering work in the 1990s to the present, the benchmark of platelet numbers and the functional characteristics of the growth factors, cell adhesion molecules, and homing signals of PRP/PRF have progressed to a mature science and easy-to-use point-of-care devices. Today, PRP/PRF devices are able to predictably concentrate platelets to known therapeutic levels by a variety of technologic means and to include or exclude leukocytes as per the needs of the wound. PRP/PRF has become a mainstay in bone regeneration in dental implantology and jaw reconstruction, for tendon and joint repair in orthopedics, for soft tissue healing in wound care centers, and in plastic surgery; it has thus benefited hundreds of thousands of patients worldwide. As one of several individuals who were there at the beginning of the PRP/PRF discovery and who helped to move it along the way somewhat, I am delighted to see that the next generation of clinical researchers as published in Understanding Platelet-Rich Fibrin have brought it to the next level. This text is written for the clinician to understand how and why PRF promotes healing of both bone and soft tissue as well as how to apply it to improve their own results. Written with a balanced blend of science and clinical applications by the most experienced and accomplished PRP/PRF scientists and clinicians of the day, and beautifully illustrated, Understanding Platelet-Rich Fibrin is a book for this decade that transcends all specialties of dentistry and many of medicine. Robert E. Marx, DDS Professor of Surgery and Chief of OMFS University of Miami Miller School of Medicine Miami, Florida

Preface

Contributors

Abbreviations

1Evolution of Platelet Concentrates

SECTION I | BIOLOGY OF PRF

2Biology of PRF: Fibrin Matrix, Growth Factor Release, and Cellular Activity

3Horizontal Versus Fixed-Angle Centrifugation of PRF: Optimization of C-PRF

4Understanding Relative Centrifugal Force (G-Force)

5Protocols for PRF

6Importance of Centrifugation Tubes for the Production of PRF

7Biologic Characterization of e-PRF Membranes

8Armamentarium in a PRF Kit

9Phlebotomy

10Fabricating Various PRF Modalities

11Overview of Clinical Indications Using PRF

SECTION II | PERIODONTOLOGY

12Use of PRF for the Treatment of Gingival Recessions

13Use of PRF for the Treatment of Intrabony and Furcation Defects

14Use of PRF for Extraction Site Management

SECTION III | IMPLANT DENTISTRY

15Use of PRF as an Adjunct Therapy to Implant Dentistry

16Use of PRF in Guided Bone Regeneration

17Use of PRF for Sinus Grafting

SECTION IV | ADDITIONAL DENTAL AND MEDICAL APPLICATIONS

18Use of PRF in Oral and Maxillofacial Surgery

19Use of PRF in Regenerative Endodontics

20Use of PRF in Facial Esthetics

21Medical Uses of PRF

22Future Research with PRF

Index

Dedication

I would like to dedicate this textbook specifically to Dr Fatiha Chandad and the Dental Faculty at the University of Laval in Quebec, Canada, who devoted countless hours to training students like me in dentistry.

Dr Chandad, Dean of Dental Research, was someone who motivated me and more importantly made it possible for students to work within her laboratory on research projects during their 4 years of dental studies. It was here that I first started my research activities on PRP/PRF and became fascinated with research as a whole. Dr Chandad is one of the only people I have ever met never wanting to be recognized for her achievements, instead insisting that her students be recognized and at the forefront of their own success. It was during these times that I was awarded the prestigious Hatton Award in Canada and was later named the IADR Young Investigator of the Year in Implant Dentistry.