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Introduction

General Considerations

Bacterial Salivary Gland Infections Acute Bacterial Parotitis Variants of ABP and Their Etiology Diagnosis of Acute Bacterial Parotitis Treatment of Acute Bacterial Parotitis Chronic (Recurrent or Refractory) Bacterial Parotitis Treatment of Chronic Bacterial Parotitis Chronic Recurrent Juvenile Parotitis Treatment of Chronic Recurrent Juvenile Parotitis Acute Bacterial Submandibular Sialadenitis Treatment of Acute Bacterial Submandibular Sialadenitis Chronic Recurrent Submandibular Sialadenitis Bartonella Henselae (Cat‐Scratch Disease) Tuberculous Mycobacterial Disease Nontuberculous Mycobacterial Disease

Viral Salivary Gland Infections Mumps Human Immunodeficiency Virus Influenza A

Bacterial Sialadenitis in Pregnancy

Autoimmune Sialadenitis and IgG4‐Related Disease

Summary

Case Presentation – Gadzooks

References

Most non‐neoplastic swellings of the major salivary glands represent acute or chronic infections of these glands. Sialadenitis, a generic term used to describe infection of the salivary glands, has a diverse range of signs and symptoms and predisposing factors. Although any of the major and minor salivary glands can become infected, these conditions most commonly occur in the parotid ( Figure 3.1) and submandibular glands ( Figure 3.2), with minor salivary gland and sublingual gland infections being very rare. From an etiologic standpoint, these infections may be related to underlying bacterial, viral, fungal, mycobacterial, parasitic, or immunologically mediated inflammation/infections (Miloro and Goldberg 2002). The most common of these diagnoses include acute bacterial parotitis and acute submandibular sialadenitis (see Table 3.1). Numerous risk factors may predispose patients to sialadenitis. The classic risk factor is the hospitalized patient who recently underwent surgery with general anesthesia. Additionally, dehydration (insufficient intake) may contribute to sialadenitis, as may chronic nausea/vomiting (excessive output) in hospitalized patients. Both conditions decrease intravascular volume, thereby decreasing perfusion of salivary gland tissue with resultant decreased salivary flow. In general terms, stasis and decreased salivary flow predispose patients to sialadenitis, although, medications and comorbid diagnoses may also contribute to this diagnosis (see Table 3.2).