Salivary Gland Pathology

1 Cover

2 Title Page

3 Copyright Page

4 Contributors

5 Foreword First Edition

6 Foreword Second Edition

7 Foreword Third Edition

8 Preface First Edition

9 Preface Second Edition

10 Preface Third Edition

11 Acknowledgments

12 About the Companion Website

13 Chapter 1: Surgical Anatomy, Embryology, and Physiology of the Salivary Glands Introduction Parotid Gland Submandibular Gland Sublingual Gland Minor Salivary Glands Tubarial Salivary Glands Histology of the Salivary Glands Control of Salivation Summary Case Presentation – Wait, What? References

14 Chapter 2: Diagnostic Imaging of Salivary Gland Pathology Introduction Imaging Modalities Diagnostic Imaging Anatomy Pathology of the Salivary Glands Summary Case Presentation – Duplicity References

15 Chapter 3: Infections of the Salivary Glands Introduction General Considerations Bacterial Salivary Gland Infections Viral Salivary Gland Infections Bacterial Sialadenitis in Pregnancy Autoimmune Sialadenitis and IgG4‐Related Disease Summary Case Presentation – Gadzooks References

16 Chapter 4: Cysts and Cyst‐Like Lesions of the Salivary Glands Introduction Mucous Escape Reaction Mucous Retention Cyst Parotid Cysts Associated with Human Immunodeficiency Virus Infection Branchial Cleft Cysts Parotid Neoplasms Masquerading as Cysts Summary Case Presentation ‐ Down Yonder References

17 Chapter 5: Sialolithiasis Introduction Pathophysiology of Sialolithiasis Clinical Features of Sialolithiasis Differential Diagnosis and Diagnosis of Sialolithiasis Treatment of Sialolithiasis Sialolithiasis of the Sublingual Gland and Minor Salivary Glands The Relationship of Salivary Lithiasis to Nephrolithiasis, Cholelithiasis, Primary Hyperparathyroidism, and Gout Summary Case Presentation – Stoneorama References

18 Chapter 6: Systemic Diseases Affecting the Salivary Glands Introduction Sjögren Syndrome Sarcoidosis Sialosis IgG4‐Related Disease Summary Case Presentation – Esoterica References

19 Chapter 7: Salivary Gland Pathology in Children and Adolescents Introduction Nonneoplastic Salivary Gland Lesions Neoplastic Salivary Gland Disease Summary Case Presentation – Size Matters References

20 Chapter 8: Classification, Grading, and Staging of Salivary Gland Tumors Introduction Classification Systems for Salivary Gland Neoplasms Grading and Staging of Salivary Gland Tumors TNM and Staging of Salivary Gland Tumors Summary Case Presentation – Reclassified References

21 Chapter 9: The Molecular Biology of Benign and Malignant Salivary Gland Tumors Introduction: The Puzzle and the Promise Salivary Gland Tumor Cell Biology Molecular Biology of Salivary Gland Neoplasms Summary and Clinical Applications Summary References

22 Chapter 10: Tumors of the Parotid Gland Introduction Etiology and Epidemiology Diagnosis Surgical Management Summary Case Presentation – How Did This All Start? References

23 Chapter 11: Tumors of the Submandibular and Sublingual Glands Introduction Epidemiology and Etiology Diagnosis Management Summary Case Presentation – But I Took the Road Less Traveled References

24 Chapter 12: Tumors of the Minor Salivary Glands Introduction Etiology of Minor Salivary Gland Tumors Diagnosis of Minor Salivary Gland Tumors Treatment of Minor Salivary Gland Tumors Summary Case Presentation – Two Peas in a Pod References

25 Chapter 13: Radiation Therapy for Salivary Gland Malignancies Introduction Low‐Risk Salivary Gland Malignancies Moderate‐Risk Salivary Gland Malignancies High‐Risk Salivary Gland Malignancies Evolution of Radiation Techniques in Salivary Gland Malignancies Complications of Radiation Therapy in Salivary Gland Malignancies Radiation Technique for Low‐ and Moderate‐Risk Salivary Gland Tumors Radiation Technique for High‐Risk Salivary Gland Tumors Advanced Radiation Therapy Techniques Summary References

26 Chapter 14: Systemic Therapy for Salivary Gland Cancer Introduction Epidemiology and Risk Factors Molecular Biology of Salivary Gland Tumors Clinical Presentation Treatment Summary References

27 Chapter 15: Non‐salivary Tumors of the Salivary Glands Introduction Mesenchymal Tumors Epithelial Non‐salivary Tumors Tumors of Salivary Gland Lymph Nodes Miscellaneous Summary Case Presentation – From One Salivary Gland to Another References

28 Chapter 16: Trauma and Injuries to the Salivary Glands Introduction Penetrating Injuries Radiation Injury Barotrauma Summary (Figures 16.22 and 16.23) References

29 Chapter 17: Miscellaneous Pathologic Processes of the Salivary Glands Introduction Hereditary and Congenital Conditions Saliva Ischemic/Degenerative Changes Küttner Tumor Salivary Gland Biopsy for Systemic Disease Summary Case Presentation – The Great Pretender References

30 Chapter 18: Complications of Salivary Gland Surgery Introduction General Considerations Complications of Parotid Gland Surgery Parotid Duct Leakage Complications of Submandibular and Sublingual Gland Surgery Complications Associated with Removal of Minor Salivary Gland Mucocele Summary Case Presentation – Get It Right the First Time. That's the Main Thing References

31 Chapter 19: Innovations in Salivary Gland Surgery Minimally Invasive Parotid Gland Surgery Minimally Invasive Sublingual Gland Surgery Minimally Invasive Salivary Gland Surgery with Sialendoscopy Summary References

32 Index

33 End User License Agreement

1 Chapter 2 Table 2.1. CT density in Hounsfield units (H). Table 2.2. Tissue characteristics on T1 and T2 MRI. a Table 2.3. Standard uptake value (SUV) of salivary glands.

2 Chapter 3 Table 3.1. Classification of salivary gland inflammation/infection. Table 3.2. Risk factors associated with salivary gland inflammation/infection...

3 Chapter 4 Table 4.1. Cysts and cyst‐like lesions of the salivary glands – nomenclature ...Table 4.2. Classification and examples of cystic lesions of the parotid gland...

4 Chapter 5Table 5.1. Composition of normal adult saliva.

5 Chapter 6Table 6.1. Frequency of extraglandular findings in primary Sjögren syndrome.Table 6.2. Clinical involvement by sarcoidosis.Table 6.3. Classification of sialosis.

6 Chapter 7Table 7.1. Inflammatory and infectious diseases of the salivary glands in chi...Table 7.2. Comparison of the reported incidence of epithelial salivary gland ...

7 Chapter 8Table 8.1. 2017 WHO classification of salivary gland tumors.Table 8.2. Grading of malignant salivary gland tumors.Table 8.3. Staging of malignant salivary gland tumors.

8 Chapter 11Table 11.1. Sublingual gland tumors 1990–2020 (Experience of Drs. Carlson and...

9 Chapter 12Table 12.1. Incidence of minor salivary gland tumors.Table 12.2. Incidence of benign and malignant minor salivary gland tumors at ...Table 12.3. Management of the anatomic barriers in minor salivary gland tumor...

10 Chapter 14Table 14.1. Chemotherapy in the treatment of metastatic or recurrent salivary...Table 14.2. Targeted therapy in the treatment of metastatic or recurrent sali...

11 Chapter 18Table 18.1. House–Brackmann facial paralysis scale.Table 18.2. Dosage per type A botulinum formulation for the treatment of Frey...

1 Chapter 1 Figure 1.1. A lateral view of the skull showing some of the bony features re... Figure 1.2. The parotid gland and associated structures. Figure 1.3. The mandibulo‐stylohyoid ligament. Figure 1.4. Anatomical landmarks of the extratemporal facial nerve. Figure 1.5. Clinical photograph of dissected facial nerve following superfic... Figure 1.6. The branching patterns of the facial nerve. Figure 1.7. The facial nerve and its relationship to the retromandibular vei... Figure 1.8. The surface markings for the location of the parotid duct. Figure 1.9. The parasympathetic innervations of the salivary glands. The par... Figure 1.10. The relationship of the superficial and deep lobes of the subma... Figure 1.11 Superficial dissection of the left submandibular gland. The inve... Figure 1.12. Deep dissection of the left submandibular gland. With the subma... Figure 1.13. Clinical photograph showing the relationship of the lingual ner... Figure 1.14. Diagram showing the histology of the major components of the sa... Figure 1.15. Axial (a) and coronal (b) CT angiogram of the neck demonstratin...