Joe Mayhew - Large Animal Neurology

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Third edition

I. G. Joe Mayhew

Massey University

Palmerston North, NZ

Robert J. MacKay

University of Florida

Gainesville, Florida, USA

This edition first published 2022 © 2022 John Wiley & Sons Ltd

Edition History John Wiley & Sons Ltd (2e, 2008), Lea & Febiger (1e, 1989)

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Limit of Liability/Disclaimer of Warranty The contents of this work are intended to further general scientific research, understanding, and discussion only and are not intended and should not be relied upon as recommending or promoting scientific method, diagnosis, or treatment by physicians for any particular patient. In view of ongoing research, equipment modifications, changes in governmental regulations, and the constant flow of information relating to the use of medicines, equipment, and devices, the reader is urged to review and evaluate the information provided in the package insert or instructions for each medicine, equipment, or device for, among other things, any changes in the instructions or indication of usage and for added warnings and precautions. While the publisher and authors have used their best efforts in preparing this work, they make no representations or warranties with respect to the accuracy or completeness of the contents of this work and specifically disclaim all warranties, including without limitation any implied warranties of merchantability or fitness for a particular purpose. No warranty may be created or extended by sales representatives, written sales materials or promotional statements for this work. The fact that an organization, website, or product is referred to in this work as a citation and/or potential source of further information does not mean that the publisher and authors endorse the information or services the organization, website, or product may provide or recommendations it may make. This work is sold with the understanding that the publisher is not engaged in rendering professional services. The advice and strategies contained herein may not be suitable for your situation. You should consult with a specialist where appropriate. Further, readers should be aware that websites listed in this work may have changed or disappeared between when this work was written and when it is read. Neither the publisher nor authors shall be liable for any loss of profit or any other commercial damages, including but not limited to special, incidental, consequential, or other damages.

Library of Congress Cataloging‐in‐Publication Data applied for [HB ISBN: 9781119477037]

Cover Design: Wiley

Cover Images: Courtesy of Quentin Roper, Courtesy of Joe Mayhew

For this third edition of Large Animal Neurology , we have enlisted Rob MacKay as coauthor to help us keep up with current trends and to maintain a reasonably worldwide—albeit somewhat Anglosphere—perspective.

As with previous editions, the general structure of the book consists of three parts. Part I( Chapters 1– 4) covers the background disciplines required for the evaluation of neurologic cases; Part II( Chapters 5– 30) provides concise overviews of the commonly encountered, major clinical presenting scenarios; and Part III( Chapters 31– 38) offers an extensively resourced discourse of most neurologic diseases of domestic large animals following an etiologic category. Readers thus can approach the text with a view to updating their evaluation of suspected clinical neurologic patients ( Part I), with a specific clinical syndrome in mind ( Part II), or to delve into details on most of the specific neurologic diseases of large domestic animals ( Part III).

Since the second edition of 2008, genetics and modern imaging techniques, in particular, have had a major impact on large animal neurology. Despite their profound utility, these diagnostic tests are not perfect. Thus, even dramatic and clearly defined changes seen on an MR or a CT image of a patient with a neurologic syndrome does not always indicate cause and effect. Likewise, as our genetic modeling of many diseases unravels, particularly of those with complex genetic characteristics, identifying a genetic association with a particular disorder does not mean that the patient’s signs are due solely to that inborn—or even acquired—genetic fingerprint. Therefore, as with all diagnostic ancillary aids we use, the results must be taken in conjunction with the results of repeated examinations to help formulate the most appropriate diagnostic and therapeutic plans. It also must be considered before undertaking any test, whether the results, considering their margin of error, will inform clinical management to a degree that benefit outweighs risk and cost. Otherwise, we might be better off not undertaking them.