Naoki Sugimoto - Chemistry and Biology of Non-canonical Nucleic Acids

13 Chapter 13Figure 13.1 Different types of oligonucleotide therapeutics. Antisense oligo...Figure 13.2 Functional mechanisms of antisense oligonucleotides. (a) Functio...Figure 13.3 Chemical structures of natural phosphodiester backbone and phosp...Figure 13.4 Examples of nonnatural chemical modifications in ribose unit. Ch...Figure 13.5 Chemical structures of oligonucleotides consisting of unnatural ...Figure 13.6 Functional mechanisms of aptamer-based modulation of cell signal...Figure 13.7 Examples of chemical structures of aminoglycosides and their com...Figure 13.8 Chemical structures of flavin mononucleotide (FMN) and ribocil a...Figure 13.9 Schematic illustrations of (a) small-molecule microarray and (b)...Figure 13.10 Functional mechanisms of oligonucleotides inducing non-canonica...

14 Chapter 14Figure 14.1 Structures of TBA G4. (a) Illustration of TBA G4. (b) Tertiary s...Figure 14.2 Schematic illustrations of apoptosis induction by AS1411. (a) In...Figure 14.3 The G4 domains of spinach RNA aptamer (PDB ID: 4KZD).Figure 14.4 (a) The reaction scheme of hemin-G4 DNAzyme. DNAzyme's oxidative...Figure 14.5 (a) The precursor, 5′-(3,5-bis(allyloxy)benzoyl)-2′,3′-isopropyl...Figure 14.6 NMR solution structure of the RHAU-N terminus domain (RNAU N-ter...Figure 14.7 Translational regulation through the interplay of G4 destabiliza...Figure 14.8 Illustration of ligand-conjugated oligonucleotide probe.Figure 14.9 G4 structures acting as thermoswitches. Since G4 blocks the tran...Figure 14.10 Mechanism of fluorescence detection of potassium ion using a G4...Figure 14.11 G4-based crowding sensor acting by G4 topology changes. (a) The...

15 Chapter 15Figure 15.1 The chemical structures of (a) choline dihydrogen phosphate (cho...Figure 15.2 Interaction of choline ion with DNA structures of (a) duplex, (b...Figure 15.3 Factors of determinants of duplex stability.Figure 15.4 Factors of determinants of G-quadruplex stability.Figure 15.5 Image of volumetric changes occurring in the duplex formation.Figure 15.6 Graphical image of volumetric change of G-quadruplex DNA. V Mis ...Figure 15.7 Effect of co-transcriptionally and kinetically formed metastable...Figure 15.8 Mechanism of signaling aptamer for fluorometric detection of a t...Figure 15.9 Optimization process of light-up aptamer using RNA-capturing mic...

1 Cover

2 Table of Contents

3 Begin Reading

1 iii

2 iv

3 xi

4 xii

5 1

6 2

7 3

8 4

9 5

10 6

11 7

12 8

13 9

14 10

15 11

16 12

17 13

18 14

19 15

20 16

21 17

22 18

23 19

24 20

25 21

26 22

27 23

28 24

29 25

30 26

31 27

32 28

33 29

34 30

35 31

36 32

37 33

38 34

39 35

40 36

41 37

42 38

43 39

44 40

45 41

46 42

47 43

48 44

49 45

50 46

51 47

52 48

53 49

54 50

55 51

56 52

57 53

58 54

59 55

60 56

61 57

62 58

63 59

64 60

65 61

66 62

67 63

68 64

69 65

70 66

71 67

72 68

73 69

74 70

75 71

76 72

77 73

78 74

79 75

80 76

81 77

82 78

83 79

84 80

85 81

86 82

87 83

88 84

89 85

90 86

91 87

92 88

93 89

94 90

95 91

96 92

97 93

98 94

99 95

100 96

101 97

102 98

103 99

104 100

105 101

106 102

107 103

108 104

109 105

110 106

111 107

112 108

113 109

114 110

115 111

116 112

117 113

118 114

119 115

120 116

121 117

122 118

123 119

124 120

125 121

126 122

127 123

128 124

129 125

130 126

131 127

132 128

133 129

134 130

135 131

136 132

137 133

138 134

139 135

140 136

141 137

142 138

143 139

144 140

145 141

146 142

147 143

148 144

149 145

150 146

151 147

152 148

153 149

154 150

155 151

156 152

157 153

158 154

159 155

160 156

161 157

162 158

163 159

164 160

165 161

166 162

167 163

168 164

169 165

170 166

171 167

172 168

173 169

174 170

175 171

176 172

177 173

178 174

179 175

180 176

181 177

182 178

183 179

184 180

185 181

186 182

187 183

188 184

189 185

190 186

191 187

192 188

193 189

194 190

195 191

196 192

197 193

198 194

199 195

200 196

201 197

202 198

203 199

204 200

205 201

206 202

207 203

208 204

209 205

210 206

211 207

212 208

213 209

214 210

215 211

216 212

217 213

218 214

219 215

220 216

221 217

222 218

223 219

224 220

225 221

226 222

227 223

228 224

229 225

230 226

231 227

232 228

233 229

234 230

235 231

236 232

237 233

238 234

239 235

240 236

241 237

242 238

243 239

244 240

245 241

246 242

247 243

248 244

249 245

250 246

251 247

252 248

253 249

254 250

255 251

256 252

257 253

258 254

259 255

260 256

261 257

262 258

263 259

264 260

265 261

266 262

267 263

268 264

269 265

270 266

271 267

272 268

273 269

274 270

275 271

276 272

277 273

278 274

279 275

280 276

281 277

Naoki Sugimoto

Author

Prof. Naoki SugimotoKonan University Frontier Institute for Biomolecular Engineering 7-1-20 Minatojima-minamimachi 650-0047 Kobe Japan

All books published by Wiley-VCHare carefully produced. Nevertheless, authors, editors, and publisher do not warrant the information contained in these books, including this book, to be free of errors. Readers are advised to keep in mind that statements, data, illustrations, procedural details, or other items may inadvertently be inaccurate.

Library of Congress Card No.:applied for

British Library Cataloguing-in-Publication DataA catalogue record for this book is available from the British Library.

Bibliographic information published by the Deutsche NationalbibliothekThe Deutsche Nationalbibliothek lists this publication in the Deutsche Nationalbibliografie; detailed bibliographic data are available on the Internet at < http://dnb.d-nb.de>.

© 2021 WILEY-VCH GmbH, Boschstr. 12, 69469 Weinheim, Germany

All rights reserved (including those of translation into other languages). No part of this book may be reproduced in any form – by photoprinting, microfilm, or any other means – nor transmitted or translated into a machine language without written permission from the publishers. Registered names, trademarks, etc. used in this book, even when not specifically marked as such, are not to be considered unprotected by law.