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Edited by

Gregory Y. Lauwers, MD, FAGPS

Senior Member and Director, Gastrointestinal Pathology Service

Department of Pathology, Moffitt Cancer Center

Professor, Departments of Pathology and Cell Biology and Oncologic Sciences

University of South Florida

Tampa, FL, USA

Michael B. Wallace, MD, MPH

Consultant – Gastroenterology and Hepatology

Fred C. Andersen Professor of Medicine, Mayo Clinic School of Medicine

Jacksonville, FL, USA

Associate Editor:

Till S. Clauditz, MD

Associate Professor, Head of Gastrointestinal Pathology Service

Department of Pathology with Section Molecular Pathology and Cytology

University Medical Center Hamburg‐Eppendorf,

Hamburg, Germany

This edition first published 2021

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Library of Congress Cataloging‐in‐Publication Data applied for

HB ISBN: 9780470658369

Cover Design: Wiley

Cover Images: © Gregory Y. Lauwers and Michael B. Wallace

Thomas ArnasonQueen Elizabeth II Health Sciences Centre and Dalhousie University Halifax Nova Scotia Canada

Ian BrownEnvoi Specialist Pathologists Brisbane Australia

Till S. ClauditzDepartment of Pathology University‐Medical‐Center Hamburg Germany

Tze Sheng KhorPathWest Laboratory Medicine Queen Elizabeth II Medical Centre Nedlands Western Australia Australia

K. KimSamsung Medical Center Sungkyunkwan University School of Medicine Seoul South Korea

Bence Kővári Department of Pathology University of Szeged Szeged Hungary

Priyanthi KumarasingheDepartment of Anatomical Pathology PathWest, QE II Medical Centre Univ. of Western Australia Perth Australia

Gregory Y. LauwersMoffitt Cancer Center Tampa Florida USA

Jun Haeng LeeSamsung Medical Center Sungkyunkwan University School of Medicine Seoul South Korea

Laurence de LevalInstitute of Pathology University of Lausanne Lausanne Switzerland

Anthony R. MattiaNewton‐Wellesley Hospital Newton, MA USA