Gastrointestinal Pathology

6 Chapter 6Figure 6.1 Focal gastric neoplasia on lesser curvature of antrum shown in wh...Figure 6.2 Intestinal/adenomatous type dysplasia. (a) Low‐grade: It shows li...Figure 6.3 Gastric/foveolar/type 2 dysplasia. (a) Low‐grade: The lesion disp...Figure 6.4 When a diagnosis of high‐grade dysplasia or T1 carcinoma is made ...Figure 6.5 Well‐differentiated intramucosal adenocarcinoma. This example is ...Figure 6.6 Well‐differentiated adenocarcinoma of tubular type. The neoplasm ...Figure 6.7 Poorly differentiated adenocarcinoma of tubular type. It shows an...Figure 6.8 Mucinous adenocarcinoma with limited epithelial elements noted at...Figure 6.9 Signet ring cell gastric adenocarcinoma composed of individual si...Figure 6.10 EBER‐positive gastric adenocarcinoma. Marked lymphocytic infiltr...Figure 6.11 AFP‐producing gastric adenocarcinoma. Large polygonal eosinophil...Figure 6.12 Low‐grade NET (a) showing a mixed trabecular and nested growth p...Figure 6.13 Large cell neuroendocrine carcinoma composed of solid sheet of r...Figure 6.14 GIST, spindle cell variant. The lesion consists of interlacing f...Figure 6.15 GIST, epithelioid variant. The lesion shows distinctly round cel...Figure 6.16 Microscopic aspect of gastric MALT lymphoma. (a) Low magnificati...Figure 6.17 Gastric MALT lymphoma with plasma cell differentiation. (a) The ...Figure 6.18 IRTA1 expression in gastric MALT lymphoma. Positive staining in ...Figure 6.19 Control gastric biopsies after antibiotic therapy for H. pylori ‐...Figure 6.20 Primary gastric diffuse large B‐cell lymphoma presenting as a vo...Figure 6.21 Diffuse large B‐cell lymphoma of the stomach. (a) Low‐power view...Figure 6.22 Primary gastric “double‐hit” high‐grade B‐cell lymphoma with MYC Figure 6.23 Mantle cell lymphoma diagnosed on gastric biopsies in a 80‐year‐...Figure 6.24 Primary gastric sporadic Burkitt lymphoma, EBV‐negative, in a 34...Figure 6.25 Gastric involvement by an extranodal NK/T‐cell lymphoma nasal‐ty...

7 Chapter 7Figure 7.1 (a) Duodenal intraepithelial lymphocytosis with normal villous ar...Figure 7.2 Microvillous inclusion disease with vacuolization of surface epit...Figure 7.3 Electron microscopic image characteristic of the microvillous inc...Figure 7.4 Histologic evidence of a tufting enetropathy.Figure 7.5 Duodenal giardiasis. Note the variable shapes of the organisms in...Figure 7.6 Cryptosporidiosis with secondary lymphocytosis. Observe the organ...Figure 7.7 Example of strongyloides in the duodenal crypts.Figure 7.8 Low‐power view of MAI‐associated enteritis with diffuse histiocyt...Figure 7.9 (a–c) Example of Whipple's disease, characterized by infiltration...Figure 7.10 (a) Adenovirus infection with typical eosinophilic intranuclear ...Figure 7.11 CMV duodenitis with classic CMV inclusions in endothelial cell c...Figure 7.12 Endoscopic celiac disease with scalloping of the duodenal folds....Figure 7.13 Example of celiac disease, Marsh grade 1 with the characteristic...Figure 7.14 Marsh grade 3a of celiac disease with definite villous blunting....Figure 7.15 Low‐power view of autoimmune enteropathy characterized by blunti...Figure 7.16 Example of a tropical sprue with intraepithelial lymphocytosis a...Figure 7.17 Collagenous sprue with obvious expansion of the lamina propria b...Figure 7.18 Example of Crohn's ileitis with deep serpiginous ulceration, ery...Figure 7.19 Microscopic evidence of active Crohn's ileitis (a) and granuloma...Figure 7.20 NSAIDs enteropathy with superficial erosion and multifocal white...Figure 7.21 Example of the Waldenstrom disease with expansion of the lamina ...Figure 7.22 Amyloid deposition resulting in the expansion of the lamina prop...

8 Chapter 8Figure 8.1 Gastric heterotopia of the proximal duodenal bulb. Note the surfa...Figure 8.2 Gastric heterotopia. Note the surface foveolar epithelium and oxy...Figure 8.3 Pancreatic heterotopia. In this example, the heterotopia is uniqu...Figure 8.4 Ampullary adenomyoma. The lesion is composed of benign ductular e...Figure 8.5 Hamartomatous polyps in a patient with Peutz–Jeghers syndrome. Th...Figure 8.6 Intestinal pseudopolyps in a patient with inflammatory bowel dise...Figure 8.7 Brunner's gland cyst. The lesion is located underneath the mucosa...Figure 8.8 Juvenile polyp.Figure 8.9 Examples of Cronkhite–Canada polyps showing a spectrum of changes...Figure 8.10 Arteriovenous malformations detected in small bowel on capsule e...Figure 8.11 Lymphangiectasia. Note the dilated lymphatic channels containing...

9 Chapter 9Figure 9.1 Endoscopic Brunner gland adenoma in the proximal duodenum.Figure 9.2 Brunner gland hamartoma.Figure 9.3 Endoscopic appearance of pyloric gland adenoma.Figure 9.4 Pyloric gland adenoma of duodenum.Figure 9.5 Tubular adenoma of duodenum.Figure 9.6 (a) Hyperplastic polyp of duodenum. (b) Serrated adenoma of duode...Figure 9.7 Adenocarcinoma of intestinal type arising in neurofibromatosis wi...Figure 9.8 Pancreatic type adenocarcinoma in ampulla.Figure 9.9 (a) NET of the duodenum. (b) Chromogranin IHC in duodenal NET.Figure 9.10 Endoscopic US image of GCPG. The lesion is hypoechoic (dark) ari...Figure 9.11 (a) Gangliocytic paraganglioma H&E MP. (b) Gangliocytic paragang...Figure 9.12 Small GIST (1–2 cm) at 1 o'clock. The lesion arises from the fou...Figure 9.13 GIST composed of short fascicles.Figure 9.14 Inflammatory fibroid polyp of ileum LP.Figure 9.15 (a) Follicular lymphoma duodenum H&E. (b) Follicular lymphoma CD...Figure 9.16 Mantle cell lymphoma ileum HP 2.Figure 9.17 (a) Mantle cell lymphoma CD20. (b) Mantle cell lymphoma ileum CD...Figure 9.18 Burkitt lymphoma ileum.Figure 9.19 (a) IPSID. (b) IPSID CD138.Figure 9.20 (a) Mastocytosis rich in eosinophils. (b) CD117 mastocytosis. (c...

10 Chapter 10Figure 10.1 Biopsies of acute self‐limiting colitis (ASLC) show a preserved ...Figure 10.2 Colonic biopsy affected by Mycobacterium tuberculosis showing mu...Figure 10.3 Typical appearance of a spirochetosis of the colon showing a pur...Figure 10.4 H.E. stain of the colon showing typical changes caused by CMV in...Figure 10.5 Biopsy specimens of pseudomembranous colitis showing the whole s...Figure 10.6 Example of a severe amebiasis showing a severe ulcerative coliti...Figure 10.7 High magnification of a colon biopsy with a population of crypto...Figure 10.8 H.E. stain of a colonic biopsy with manifestation of Schistosoma ...Figure 10.9 H.E. stain of Syphilitic colitis (a) with a predominant lymphopl...Figure 10.10 Typical histological appearance of an early (a) and a late (b) ...Figure 10.11 H.E. stain of FAC characterized by inflammation driven by neutr...Figure 10.12 Typical finding in case of collagenous findings showing a thick...Figure 10.13 High magnification of lymphocytic colitis characterized by an i...Figure 10.14 Characteristic changes in colonic biopsies caused by mucosal pr...Figure 10.15 High magnification of a colonic biopsy with changes characteris...Figure 10.16 Example of mastocytic colitis showing a slightly increased mixe...Figure 10.17 Mycrophenolate mofetil‐related colitis is a pitfall mimicking c...Figure 10.18 Endoscopic appearance of severe Crohn's disease. (a) Deep ulcer...Figure 10.19 Endoscopic appearances of ulcerative colitis: (a) severe ulcera...Figure 10.20 Colonic mucosa with typical architectural disarray caused by UC...Figure 10.21 Colonic mucosa of UC showing a dense lymphoplasmacytic infiltra...Figure 10.22 Typical inflammatory changes of an active UC showing crypt absc...Figure 10.23 Specimen of a long‐standing UC under therapy showing scattered ...Figure 10.24 Hisological appearance of a Crohn's patient showing a dense inf...Figure 10.25 Small epithelioid granuloma found in the lamina propria of a co...Figure 10.26 Low‐grade IBD‐associated dysplasia. This lesion shows a convent...Figure 10.27 High‐grade IBD‐associated dysplasia shows crowded, focally back...Figure 10.28 Hypermucinous dysplasia typically shows a villous/tubulovillous...Figure 10.29 IBD‐associated TSA‐like dysplasia presents with narrow, slit‐li...Figure 10.30 Example of goblet cell‐deficient dysplasia (GCD) with tubular c...