Gastrointestinal Pathology

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An illustrated guide to best practices when performing
 and assessing biopsies for GI conditions of all kinds
Accurate diagnosis of GI conditions necessarily entails both the careful taking of biopsies and the informed analysis of tissue material. With that being so, gastroenterologists and GI pathologists alike must have a solid understanding of the techniques, handling requirements, and diagnostic characteristics involved if they are to collaborate effectively. 
 has been designed to provide a clinically focussed and richly illustrated guide to real-world scenarios faced by practicing GI specialists, offering step-by-step instruction and professional advice on the correct diagnosis of all major GI conditions. This essential new book includes: 
Full-color illustrations throughout Complete details of biopsy samples required to diagnose specific conditions Reviews of differential diagnoses Clinical management clues based on pathologic findings Featuring information to improve the practice of all gastroenterologists and GI pathologists, 
 is a practical and every-day resource for the precise diagnosis of a wide range of GI conditions.

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11 Chapter 11Figure 11.1 Tubulovillous adenoma with high‐grade dysplasia. Features sugges...Figure 11.2 Paris Classification of polyp shape. 0–1p refers to pedunculated...Figure 11.3 Narrow‐band imaging International Classification for Endoscopy...Figure 11.4 Hematoxylin–Eosin stain of a tubulovillous adenoma with high‐gra...Figure 11.5 Endoscopic resection of sessile serrated polyp (a) with standard...Figure 11.6 Hyperplastic polyp as seen in narrow‐band imaging model. Note th...Figure 11.7 Hyperplastic polyp presenting as a localized projection of the c...Figure 11.8 Sessile serrated lesion displaying horizontally shaped crypt bas...Figure 11.9 Sessile serrated lesion with dysplasia. This lesion was atypical...Figure 11.10 Sessile serrated lesion with dysplasia. There is a clear demarc...Figure 11.11 Endoscopic appearance of a rectal polyp being diagnosed as a trad...Figure 11.12 Traditional serrated adenoma with villous projections, ectopic ...Figure 11.13 Endoscopic examples of (a) inflammatory and (b) filiform pseudo...Figure 11.14 Typical histomorphology of a juvenile polyp with haphazardly cy...Figure 11.15 Hamartomatous polyp in a patient with Peutz–Jeghers syndrome ch...Figure 11.16 Microscopic appearance of a colonic mucosal leiomyoma with its ...Figure 11.17 Histology of a submucosal lipoma with benign well‐circumscribed...Figure 11.18 Endoscopic ultrasound (EUS) image of a lipoma arising in the su...Figure 11.19 Combined fibroblastic polyp and SSL with fibrotic changes of th...Figure 11.20 Colonic polyp with collagen bundles and thick eosinophilic elas...Figure 11.21 Colonic polypoid endometriosis with its typical glands being su...

12 Chapter 12Figure 12.1 Cecal polyp showing invasion of the lamina propria by small atyp...Figure 12.2 Various macroscopic appearances of colorectal carcinoma presenti...Figure 12.3 Medullary carcinoma of the proximal colon consisting of sheets o...Figure 12.4 Loss of immunohistochemical expression of MLH1 in a medullary ca...Figure 12.5 Metastatic melanoma in the sigmoid colon: infiltration of the co...Figure 12.6 Endometriosis presenting as a large mass in the upper rectum, mi...Figure 12.7 Endometriosis in the rectal mucosa: Endometrial glands surrounde...Figure 12.8 (a) Endoscopical appearance of malignant sessile colon polyp wit...Figure 12.9 Pseudoinvasion in the stalk of a large pedunculated tubular aden...Figure 12.10 NET of the rectum showing an anastomosing ribbon pattern infilt...Figures 12.11 and 12.12 Large cell neuroendocrine carcinoma of the rectum sh...Figures 12.13 and 12.14 Endoscopic appearance of mucosal‐associated lymphoid...

13 Chapter 13Figure 13.1 Example of anal fissure lined by inflamed granulation tissue and...Figure 13.2 (a) Large external hemorrhoid seen via anoscopy. A snare device ...Figure 13.3 Anal involvement by Crohn's disease with granulomatous inflammat...Figure 13.4 (a) Syphilis proctitis: Cryptitis and expanded lamina propria in...Figure 13.5 (a) Columnar mucosa with expanded lamina propria inflammatory in...

14 Chapter 14Figure 14.1 (a) Inflammatory cloacogenic polyp: The polyp is composed of elo...Figure 14.2 Fibroepithelial polyp: The polyp has a core containing variably ...Figure 14.3 (a) Hidradenoma papilliferum: A submucosal proliferation of papi...Figure 14.4 Squamous hyperplasia: The squamous mucosa has acanthosis (thicke...Figure 14.5 (a) Condyloma acuminatum: There is acanthosis of the squamous mu...Figure 14.6 Anal intraepithelial neoplasia grade 1/low‐grade squamous intrae...Figure 14.7 Anal intraepithelial neoplasia grade 3/high‐grade squamous intra...Figure 14.8 (a) Perianal Paget's disease: Paget's cells are scattered throug...Figure 14.9 Endoscopic view of anal squamous cell carcinoma at the 6 o'clock...Figure 14.10 (a) Invasive squamous cell carcinoma, keratinizing, with infilt...Figure 14.11 Malignant melanoma: Panel A shows a densely cellular lesion adj...

Guide

1 Cover Page

2 Title Page Gastrointestinal Pathology Correlative Endoscopic and Histologic Assessment Edited by Gregory Y. Lauwers, MD, FAGPS Senior Member and Director, Gastrointestinal Pathology Service Department of Pathology, Moffitt Cancer Center Professor, Departments of Pathology and Cell Biology and Oncologic Sciences University of South Florida Tampa, FL, USA Michael B. Wallace, MD, MPH Consultant – Gastroenterology and Hepatology Fred C. Andersen Professor of Medicine, Mayo Clinic School of Medicine Jacksonville, FL, USA Associate Editor: Till S. Clauditz, MD Associate Professor, Head of Gastrointestinal Pathology Service Department of Pathology with Section Molecular Pathology and Cytology University Medical Center Hamburg‐Eppendorf, Hamburg, Germany

3 Copyright Page

4 List of Contributors

5 Table of Contents

6 Begin Reading

7 Index

8 Wiley End User License Agreement

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