Magnetic Nanoparticles in Human Health and Medicine

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Explores the application of magnetic nanoparticles in drug delivery, magnetic resonance imaging, and alternative cancer therapy  Magnetic Nanoparticles in Human Health and Medicine Chapters written by a panel of international specialists in the field of magnetic nanoparticles and their applications in biomedicine cover magnetic hyperthermia (MHT), MRI contrast agents, biomedical imaging, modeling and simulation, nanobiotechnology, toxicity issues, and more. Readers are provided with accurate information on the use of magnetic nanoparticles in diagnosis, drug delivery, and therapeutics—featuring discussion of current problems, proposed solutions, and future research directions. Topics include magnetic nanoparticles with antioxidant activity, iron oxide nanoparticles in nanomedicine, superparamagnetic hyperthermia in clinical trials, and simulating the physics of magnetic particle heating for biomedical applications. This comprehensive volume: 
Covers both general research on magnetic nanoparticles in medicine and specific applications in cancer therapeutics Discusses the use of magnetic nanoparticles in alternative cancer therapy by magnetic and superparamagnetic hyperthermia Explores targeted medication delivery using magnetic nanoparticles as a future replacement of conventional techniques Reviews the use of MRI with magnetic nanoparticles to increase the diagnostic accuracy of medical imaging 
 is a valuable resource for researchers in the fields of nanomagnetism, nanomaterials, magnetic nanoparticles, nanoengineering, biopharmaceuticals nanobiotechnologies, nanomedicine,and biopharmaceuticals, particularly those focused on cancer diagnosis and therapeutics.

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14 Chapter 14Figure 14.1 2D assembly of nanospheres on a square super‐lattice of paramete...Figure 14.2 Linear susceptibility χ eqas a function of the (reduced) lo...Figure 14.3 SAR as a function of X (see text) for various values of the long...Figure 14.4 The SAR as a function of the longitudinal DC field for various v...Figure 14.5 Equilibrium susceptibility as a function of the DC field for sam...Figure 14.6 SAR, (a) linear ( Magnetic Nanoparticles in Human Health and Medicine - изображение 4) and (b) nonlinear ( Magnetic Nanoparticles in Human Health and Medicine - изображение 5), as a function of the ...Figure 14.7 Log‐Log plot of the linear and nonlinear SAR as a function of th...Figure 14.8 (a) Linear and (b) Non linear SAR as a function of the AC field ...Figure 14.9 Thermal behavior of the successive contributions to SAR for a mo...Figure 14.10 Successive contributions to SAR against the AC field intensity,...Figure 14.11 Successive contributions to SAR against the AC field frequency,...

15 Chapter 15Figure 15.1 Comparison of MC‐simulation, LRT, and SWMBT for size‐dependent S...Figure 15.2 Comparison of MC‐simulation, LRT, and SWMBT for field amplitude‐...Figure 15.3 MC-simulation for field amplitude-dependent SLP for various anis...Figure 15.4 Comparison of MC‐simulation, LRT, and SWMBT for frequency‐depend...Figure 15.A.1 Flow diagram of Monte Carlo simulation implementation. The inp...

16 Chapter 16Figure 16.1 Physical and chemical factors of magnetic nanoparticles, determi...Figure 16.2 (a) Transmission electron microscopy micrograph of one cell of M ...Figure 16.3 Magnetosome particles isolated from Magnetospirillum gryphiswald ...Figure 16.4 Overview of in vitro toxicity assays. Cell image adapted from (M...Figure 16.5 Ferrofluids containing IONPs are synthesized and characterized a...

17 Chapter 17Figure 17.1 Crystalline structure of the magnetite phase.Figure 17.2 (a) Magnetization vs. applied field characteristic of ferromagne...Figure 17.3 Evolution of the magnetite composition with the NPs size.Figure 17.4 (a) Magnetization of different ferrites and its influence on tr...Figure 17.5 Axial spin echo T 2‐weighted MR image (TR/TE: 3000/15 ms, 24 echo...Figure 17.6 Axial spin echo T 2‐weighted MR Image of 3T6 fibroblast samples (...Figure 17.7 Majors events associated with the clinical trials of magnetic hy...Figure 17.8 SAR and hysteresis loop area (A) versus (a) glycerol fraction (%...Figure 17.9 Measured temperature change of increasing concentrations of magn...Figure 17.10 Heating measurement under photothermal irradiation (1064 nm at ...Figure 17.11 In vivo heat therapy. (a) Thermal images obtained with the IR c...Figure 17.12 Temperature increase of CT‐26 tumor‐bearing mice after intraven...

18 Chapter 18Figure 18.1 MHT in a patient with a malignant brain tumor. (a) Following the...Figure 18.2 Thermotherapy treatment of the pelvic region after intratumoral ...Figure 18.3 Glioblastoma recurrence. (a,b) Pretreatment brain MRI. (c,d) Pos...Figure 18.4 Application of nanoparticle suspension into the prostate is carr...Figure 18.5 Computerized tomography scans of the prostate performed before (...Figure 18.6 Optimal specific loss power within the allowable biological limi...Figure 18.7 The time variation of the heating temperature of the magnetic na...Figure 18.8 Schematic representation of magnetic hyperthermia therapy in the...Figure 18.9 In vivo hyperthermia treatment of cancer. (a) Schematics of magn...Figure 18.10 (a) Schematic representation of injectable thermo‐sensitive mag...Figure 18.11 The trio of synchronized combined hyperthermia, chemotherapy, a...Figure 18.12 The 5‐FU loaded Fe 3O 4@anti‐HER2 nanoparticles (500 mg ml −1...Figure 18.13 Individual temperature dosages over tumor areas. (a) By using t...Figure 18.14 Synergistic effect between chemotherapy and MHT. Photographs of...Figure 18.15 Nanocube‐mediated heating in suspension. (a) Transmission elect...Figure 18.16 In vivo heat therapy. (a) Thermal images obtained with the IR c...

Guide

1 Cover Page

2 Title Page

3 Copyright Page

4 List of Contributors

5 Table of Contents

6 Begin Reading

7 Index

8 WILEY END USER LICENSE AGREEMENT

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