Peter J. Harrington - Routes to Essential Medicines

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This comprehensive workbook helps readers become familiar with the structures and synthetic challenges associated with nearly 300 essential medicines and gain the skills needed for pharmaceutical development.
Highlights nearly three hundred medicines on the latest World Health Organization (WHO) Model List of Essential Medicines and their manufacturing routes Features exercises that equip students with the skills necessary to solve similar real-world problems Includes a retrosynthetic analysis for each commodity chemical and supplies an extensive list of key journal and information sites and a library of reagents, solvents, and conditions for many common organic reactions

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Routes to Essential Medicines

A Workbook for Organic Synthesis

Peter J. Harrington

Better Pharma Processes, LLC

Louisville, CO, USA

This edition first published 2022 2022 John Wiley Sons Inc All rights - фото 1

This edition first published 2022

© 2022 John Wiley & Sons, Inc.

All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, except as permitted by law. Advice on how to obtain permission to reuse material from this title is available at http://www.wiley.com/go/permissions.

The right of Peter J Harrington to be identified as the author of this work has been asserted in accordance with law.

Registered Office John Wiley & Sons, Inc., 111 River Street, Hoboken, NJ 07030, USA

Editorial Office 111 River Street, Hoboken, NJ 07030, USA

For details of our global editorial offices, customer services, and more information about Wiley products visit us at www.wiley.com.

Wiley also publishes its books in a variety of electronic formats and by print‐on‐demand. Some content that appears in standard print versions of this book may not be available in other formats.

Limit of Liability/Disclaimer of Warranty In view of ongoing research, equipment modifications, changes in governmental regulations, and the constant flow of information relating to the use of experimental reagents, equipment, and devices, the reader is urged to review and evaluate the information provided in the package insert or instructions for each chemical, piece of equipment, reagent, or device for, among other things, any changes in the instructions or indication of usage and for added warnings and precautions. While the publisher and authors have used their best efforts in preparing this work, they make no representations or warranties with respect to the accuracy or completeness of the contents of this work and specifically disclaim all warranties, including without limitation any implied warranties of merchantability or fitness for a particular purpose. No warranty may be created or extended by sales representatives, written sales materials or promotional statements for this work. The fact that an organization, website, or product is referred to in this work as a citation and/or potential source of further information does not mean that the publisher and authors endorse the information or services the organization, website, or product may provide or recommendations it may make. This work is sold with the understanding that the publisher is not engaged in rendering professional services. The advice and strategies contained herein may not be suitable for your situation. You should consult with a specialist where appropriate. Further, readers should be aware that websites listed in this work may have changed or disappeared between when this work was written and when it is read. Neither the publisher nor authors shall be liable for any loss of profit or any other commercial damages, including but not limited to special, incidental, consequential, or other damages.

Library of Congress Cataloging‐in‐Publication Data applied for:

ISBN: 9781119722861

Cover image: [Production Editor to insert]

Cover design by [Production Editor to insert]

This workbook is dedicated to everyone who made it their mission in life to discover and manufacture Essential Medicines and to: Professor Louis S. Hegedus

Who inspired this workbook project with a lesson learned at Colorado State University: An hour in the library will save you from two weeks of floundering around in the laboratory.

About the Companion Website

www.wiley.com/go/Harrington/routes_essential_medicine

Introduction

While teaching undergraduate Organic Chemistry at University of Colorado, I was asked if I could teach a course in organic synthesis. I have worked as synthetic organic chemist and educator for my entire career (Princeton University, Colorado State University, SUNY Binghamton, Syntex, Roche, University of Denver, University of Colorado, and Better Pharma Processes, LLC) but I realized I was not prepared to teach the course. This workbook project began with that missed opportunity.

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