258 251
259 252
260 253
261 254
262 255
263 256
264 257
265 258
266 259
267 260
268 261
269 262
270 263
271 264
272 265
273 266
274 267
275 268
276 269
277 270
278 271
279 272
280 273
281 274
282 275
283 276
284 277
285 278
286 279
287 280
288 281
289 282
290 283
291 284
292 285
293 286
294 287
295 288
296 289
297 290
298 291
299 292
300 293
301 294
302 295
303 296
304 297
305 298
306 299
307 300
308 301
309 302
310 303
311 304
312 305
313 306
314 307
315 308
316 309
317 310
318 311
319 312
320 313
321 314
322 315
323 316
324 317
325 318
326 319
327 320
328 321
329 322
330 323
331 324
332 325
333 326
334 327
335 328
336 329
337 330
338 331
339 332
340 333
341 334
342 335
343 336
344 337
345 338
346 339
347 340
348 341
349 342
350 343
351 344
352 345
353 346
354 347
355 348
356 349
357 350
358 351
359 352
360 353
361 354
362 355
363 356
364 357
365 358
366 359
367 360
368 361
369 362
370 363
371 364
372 365
373 366
374 367
375 368
376 369
377 370
378 371
379 372
380 373
381 374
382 375
383 376
384 377
385 378
386 379
387 380
388 381
389 382
390 383
391 384
392 385
393 386
394 387
395 388
396 389
397 390
398 391
399 392
400 393
401 394
402 395
403 396
404 397
405 398
406 399
407 400
408 401
409 402
410 403
411 404
412 405
413 406
414 407
415 408
416 409
417 410
418 411
419 412
420 413
421 414
422 415
423 416
424 417
425 418
426 419
427 420
428 421
429 422
430 423
431 424
432 425
433 426
434 427
435 428
436 429
437 430
438 431
439 432
440 433
441 434
442 435
443 436
444 437
445 438
446 439
447 440
448 441
449 442
450 443
451 444
452 445
453 446
454 447
455 448
456 449
457 450
458 451
459 452
460 453
461 454
462 455
463 456
464 457
465 458
466 459
467 460
468 461
469 462
470 463
471 464
472 465
473 466
474 467
475 468
476 469
477 470
478 471
479 472
480 473
481 474
482 475
483 476
484 477
485 217
486 478
487 479
488 480
489 481
490 482
491 483
492 484
493 485
494 486
495 487
496 488
497 489
498 490
499 491
500 492
501 493
502 494
Routes to Essential Medicines
A Workbook for Organic Synthesis
Peter J. Harrington
Better Pharma Processes, LLC
Louisville, CO, USA
This edition first published 2022
© 2022 John Wiley & Sons, Inc.
All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, except as permitted by law. Advice on how to obtain permission to reuse material from this title is available at http://www.wiley.com/go/permissions.
The right of Peter J Harrington to be identified as the author of this work has been asserted in accordance with law.
Registered Office John Wiley & Sons, Inc., 111 River Street, Hoboken, NJ 07030, USA
Editorial Office 111 River Street, Hoboken, NJ 07030, USA
For details of our global editorial offices, customer services, and more information about Wiley products visit us at www.wiley.com.
Wiley also publishes its books in a variety of electronic formats and by print‐on‐demand. Some content that appears in standard print versions of this book may not be available in other formats.
Limit of Liability/Disclaimer of Warranty In view of ongoing research, equipment modifications, changes in governmental regulations, and the constant flow of information relating to the use of experimental reagents, equipment, and devices, the reader is urged to review and evaluate the information provided in the package insert or instructions for each chemical, piece of equipment, reagent, or device for, among other things, any changes in the instructions or indication of usage and for added warnings and precautions. While the publisher and authors have used their best efforts in preparing this work, they make no representations or warranties with respect to the accuracy or completeness of the contents of this work and specifically disclaim all warranties, including without limitation any implied warranties of merchantability or fitness for a particular purpose. No warranty may be created or extended by sales representatives, written sales materials or promotional statements for this work. The fact that an organization, website, or product is referred to in this work as a citation and/or potential source of further information does not mean that the publisher and authors endorse the information or services the organization, website, or product may provide or recommendations it may make. This work is sold with the understanding that the publisher is not engaged in rendering professional services. The advice and strategies contained herein may not be suitable for your situation. You should consult with a specialist where appropriate. Further, readers should be aware that websites listed in this work may have changed or disappeared between when this work was written and when it is read. Neither the publisher nor authors shall be liable for any loss of profit or any other commercial damages, including but not limited to special, incidental, consequential, or other damages.
Library of Congress Cataloging‐in‐Publication Data applied for:
ISBN: 9781119722861
Cover image: [Production Editor to insert]
Cover design by [Production Editor to insert]
This workbook is dedicated to everyone who made it their mission in life to discover and manufacture Essential Medicines and to: Professor Louis S. Hegedus
Who inspired this workbook project with a lesson learned at Colorado State University: An hour in the library will save you from two weeks of floundering around in the laboratory.
About the Companion Website
www.wiley.com/go/Harrington/routes_essential_medicine
While teaching undergraduate Organic Chemistry at University of Colorado, I was asked if I could teach a course in organic synthesis. I have worked as synthetic organic chemist and educator for my entire career (Princeton University, Colorado State University, SUNY Binghamton, Syntex, Roche, University of Denver, University of Colorado, and Better Pharma Processes, LLC) but I realized I was not prepared to teach the course. This workbook project began with that missed opportunity.
Читать дальше