Joseph Bastien - The Kiss of Death

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Chagas’ disease has become one of the major public-health problems in Latin America. Current estimates are that sixteen to eighteen million people are infected. Caused by a flagellate protozoa carried to humans via the bite of the
or
bug, it is locally referred to as the “kissing bug” because of its tendency to lodge on victims’ faces during sleep. The protozoa enters neuron tissues in the heart and other organs and causes death by irreversible cardiac and gastrointestinal lesions in thirty to forty percent of all cases, usually lying “dormant” until the debilitating chronic phase during the human host’s mid-life. Because of the long dormant phase, it has generally gone unrecognized, with chronic symptoms often attributed to other causes. Originally preying on forest animals, the
bug has infested the impoverished housing of displaced Andean migrants as forest lands and animals have been destroyed in South America. Although there is no cure for the chronic stage, the disease vectors can be controlled and possibly eliminated through improved hygiene and living conditions. No longer exclusive to Latin America, Chagas’ disease is spreading to North America and Europe with the migration of infected bugs, hosts, transfusions, and transplant organs.
The Kiss of Death
The Kiss of Death
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CSA (conventional serological antibodies), 210-11

Culture, and Chagas’ disease:

Andean ethnomedicine and, 45;

context model for control, 134-45;

housing and physical proximity of vectors and hosts in Bolivia, 88-106;

restoration of traditional and prevention in Bolivia, 29

Culture Context Triangle (CCT), 134-45

Cunha-Neto, Edécio, 232 n.7

Cunningham, D. D., 1

Curanderos.

chagasic colon and, 21;

Culture Context Model for Chagas’ prevention and, 135;

Kallawaya herbalists and Chagas’ disease, 30-45

Cuzco (Bolivia), 26

Cytokines, and immune response to T. cruzi infection, 209-10

D

Darwin, Charles, 8-11

Datura sanguinea , 44

DDT (insecticide), 34

Defecation index, for triatomes, 177

Deforestation, and environment of Bolivia, 155

Delgadillo, Francisco, 65, 66

Delgado, J., 52, 54

Deltametrina (Pirotroides), 44

Detection, of acute Chagas’ disease, 201-202

Diagnostic tests, for Chagas’ tests, 217-19. See also Xenodiagnosis

Diarrhea, and Chagas’ disease, 49, 68. See also Colon

Diary of the Beagle (Darwin), 9

Di Noia, Javier M., 168

Direct agglutination test (DA and 2-MEDA), 219

Direct ingestion, and transmission of T. cruzi, 62-64

Direct tests, for diagnosis of Chagas’ disease, 217, 218

Disability-adjusted life years (DALYs), 150

Diseases, of Old World origin and Spanish conquest of Inca, 27

Diviners:

Culture Context Model for Chagas’ prevention and, 136;

Kallawaya herbalists and Chagas’ disease, 30-45

D0870 (drug), 225

Dogs, infection with T. cruzi, 47, 194-95

Dominguez, A., 200

Donkeys, as hosts for T. cruzi, 195

Dosages, of nifurtimox and benznidazole, 50, 220

Drugs. See Chemotherapy

Drum and Stethoscope: Integrating Ethnomedicine and Biomedicine in Bolivia (Bastien, 1992), xvii

E

Ecology:

animals as hosts for T. cruzi, 194;

of Chuquisaca (Bolivia), 111;

Inca empire and, 25;

of Potosí (Bolivia), 65, 67;

vectorial transmission of T. cruzi and, 192. See also Climate; Environment

Economics:

chagasic heart disease and, 84;

cost of nifurtimox, 71;

Cultural Context Model for Chagas’ prevention and, 138;

decreased productivity due to Chagas’ disease, 149-53;

development and distribution of vaccines for T. cruzi, 172;

housing and Chagas’ disease in urban Bolivia, 10-104;

housing and exchange in Bolivia, 92-94;

interdisciplinary approach to prevention of Chagas’ disease, 147-48

Education, on Chagas’ disease:

biomedicine and ethnomedicine in Bolivia, 34;

children and T. infestans, 54, 56, 115-16;

concientización (consciousness-raising) and, 113-15, 122, 234 n.8;

women and, 115-16

Eggs, of T. infestans , 175

El Alto (Bolivia), 99

Electrocardiogram (ECG), and chagasic heart disease, 81, 82, 84, 165, 197, 203

ELISA test, 217, 219

El Salvador, and house infestation with T. infestans, 184

Empacho. See Colon

Endangered species, and triatomes in Andes and Amazon, 51

Entamoeba histolytica , 1

Entomology, and examination of houses in Bolivia for T. infestans, 88-89

Environment:

Culture Context Model for Chagas’ prevention, 142-43;

epidemiology of Chagas’ disease and, 182-83;

spread of Chagas’ disease in Andes and, 22-24, 154-57. See also Altitude; Climate; Ecology

Epidemiology, of Chagas’ disease:

in Bolivia, 46-64;

climate and, 182-83;

immune system and, 87

Epimastogotes, of T. cruzi , 160-61

Epitopes, 215

Eratyrus mucronatus, 191

Erythrocytic cycle, of malaria, 4

Esophagus, and Chagas’ disease:

cases of in Brazil, 231 n.7;

case study of in Chuquisaca (Bolivia), 75-76;

pathology of, 232 n.8-9

Estrada de Ferro Central do Brasil (Central Railroad of Brazil), 5-6

Ethics, biomedical:

ethnomedicine and, 34;

Indians as trial subjects for research in Bolivia, 228-29 n.2

Ethnicity:

housing and urbanization in Bolivia, 97-101;

epidemiology of Chagas’ disease in rural Bolivia, 47. See also Aymara; Guarani; Mestizos ; Quechua; Race

Ethnobotany, 149

Ethnomedicine:

Chagas’ disease and Andean, 30-45;

Culture Context Model for Chagas’ prevention, 141;

integration with biomedicine in Bolivia, xvi-xvii;

interdisciplinary approach to prevention of Chagas’ disease, 146-49

Ethnophysiology. See Humoral theory

Eucalyptus leaves, 44

Evasive strategies, of T. cruzi, 212-13, 229 n.2

EVI antibodies, 215

F

FAB (antigen-binding fragment) and Fc (crystallizable fragment), 212-13

Fabulation, and immune response to T. cruzi, 212, 213

Feces, of T. infestans , 58-59, 174, 177-78

Fetus, maternal transmission of T. cruzi, 61, 230-31 n.8. See also Congenital transmission

Fever, and Chagas’ disease:

acute phase and, 49;

as cultural illness, 68;

Kallawaya herbalists and, 38

Figaroa, Ciro, 50

Flax seeds, 42

Flight, of T. infestans, 56, 174

Food, contamination of with T. cruzi, 62

Forde, R. M., 1

Foundations, of houses and Chagas’ prevention, 120

France, and Chagas’ disease, 94

Frasch, Alberto, 168

Free market economy, and poverty in urban Bolivia, 103-104, 105

Freire, Paulo, 234 n.8

Fryer, Michelle L., 116

G

García Meza, Luis, 233 n.2

Garret, Laurie, 155

Gelbard, Robert, xix, xx

Gemio alario, Abraham, 179-80

Gender, inequality and Chagas’ disease in Bolivia, 116

Genetic variability, of T. cruzi strains, 163

Gentian violet, and blood contaminated with T. cruzi, 60, 223-24

Glycoproteins, on surface of T. cruzi, 168-70

Goats, as hosts for T. cruzi, 195

Goldbaum, M., 94

González, J., 165

González, Silverio, 147

Gregg, Linda, 148

Guarani tribes (Bolivia), 96, 97, 126, 140

Guatemala, infestation of houses with T. infestans, 184

Guayusa, and herbal medicine, 37

Guinea pigs, 194, 195

Gutiérrez, Ronald, 148

H

Hagar, J. M., xxii

Hartenberger, Paul, xix, xx

Healers of the Andes: Kallawaya Herbalists and Their Medicinal Plants (Bastien, 1987), xvii

Health:

biomedical definition of illness, 40;

Culture Context Model for Chagas’ prevention, 141;

immunopathic medicine and paradigm of, 87;

World Health Organization’s definition of, 144-45. See also Public health

Heart block, 79, 203, 204, 232 n.3

Heart disease, Chagas’:

acute phase and, 197;

case study of in Bolivia, 78-87;

cardiac pathologies, 232n.3-4;

Darwin and, 10, 11;

morbidity in rural areas of Bolivia, 47;

symptoms of chronic, 203-204;

underdiagnosis of in U.S., xxii

Herbal medicine:

exports of from Bolivia, 111-52;

interdisciplinary approach to prevention of Chagas’ disease, 149;

Kallawaya-Bolivian medicinal plants

and AIDS, cancer, Chagas’ disease, and tuberculosis, xvii;

Kallawaya herbalists and Chagas’ disease in Bolivia, 30-45

HIV, Chagas’ disease and spread of in Latin America, 86. See also AIDS

Honduras, infestation of houses with T. infestans, 184

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