Autoimmune Liver Disease

Здесь есть возможность читать онлайн «Autoimmune Liver Disease» — ознакомительный отрывок электронной книги совершенно бесплатно, а после прочтения отрывка купить полную версию. В некоторых случаях можно слушать аудио, скачать через торрент в формате fb2 и присутствует краткое содержание. Жанр: unrecognised, на английском языке. Описание произведения, (предисловие) а так же отзывы посетителей доступны на портале библиотеки ЛибКат.

Autoimmune Liver Disease: краткое содержание, описание и аннотация

Предлагаем к чтению аннотацию, описание, краткое содержание или предисловие (зависит от того, что написал сам автор книги «Autoimmune Liver Disease»). Если вы не нашли необходимую информацию о книге — напишите в комментариях, мы постараемся отыскать её.

A practical guide to autoimmune liver diseases through pathogenesis, diagnosis, and management In
, practitioners will learn about the current state of autoimmune liver disease and how to focus on their diagnosis and treatment. The four-part book begins with a thorough investigation of current immunological thinking as it relates to the autoimmunity of the liver. It also covers the four major hepatic autoimmune liver diseases in both adults and children, their management and the role of liver transplantation, and learned approaches to patient management and empowerment.
Expert authors in the field have come together to provide a thorough examination of autoimmune liver disease to help support clinicians assisting patients. The text provides an in-depth look at topics including:
● The four major hepatic autoimmune liver diseases, their diagnosis, and potential disease management
● The use (and misuse) of autoantibodies in diagnosis and treatment
● The role and timing of liver transplantation and the impact of recurrent autoimmune liver disease as well as de novo autoimmune hepatitis
● Optimal approaches to managing patients and keeping care personalised
With breadth, depth and current-day relevance,
sheds light on recent developments in management of liver disease for practitioners, nurses, and health care professionals.

Autoimmune Liver Disease — читать онлайн ознакомительный отрывок

Ниже представлен текст книги, разбитый по страницам. Система сохранения места последней прочитанной страницы, позволяет с удобством читать онлайн бесплатно книгу «Autoimmune Liver Disease», без необходимости каждый раз заново искать на чём Вы остановились. Поставьте закладку, и сможете в любой момент перейти на страницу, на которой закончили чтение.

Тёмная тема
Сбросить

Интервал:

Закладка:

Сделать

Table of Contents

1 Cover

2 Preface Preface Over the last three decades there have been many advances in the understanding of autoimmune liver disease (AILD). The advances in understanding the pathogenesis of these diseases is starting to lead to more specific therapies both for slowing or arresting progression and for treatment of the symptoms. Many people with AILD see delays in diagnosis and are misdiagnosed; treatments tend at best to control progression rather than induce resolution. Symptoms are often not treated because of either poor knowledge or inadequate therapies. Liver transplantation, a highly effective therapy for those with end‐stage disease, has its inherent risks and complications and is really a reflection of a failure to treat the original disease. Recurrence of AILD after transplantation, which manifests despite sufficient immunosuppression to prevent allograft rejection and in a foreign HLA milieu, must provide clues to some of the processes that lead to AILD but the lessons remain obscure. We have been pleased to edit this volume which we hope will not only provide a balanced and comprehensive background to the pathological and clinical aspects of AILD but also stimulate further research to provide effective therapies. We are indebted to the authors who have worked so hard to summarize complex fields. They represent some of the world leaders in this area and we are grateful to them for their time. We know there is some overlap and minor conflicts between chapters but we have retained these as we would like chapters to be comprehensive and self‐contained. We would also like to thank Deirdre Barry, Yogalakshmi Mohanakrishnan and Baskar Anandraj at Wiley for their support, patience and editorial skills and, most importantly, our families who have been patient during this time. Finally, we thank you for reading this volume and hope you find it stimulating and provoking. Whilst autoimmune liver diseases are rare, they are impactful, and every opportunity to raise awareness, standards and knowledge is an opportunity for better patient care. James Neuberger Gideon M. Hirschfield

3 Contributors

4 Abbreviations

5 Introduction

6 Section I: Scientific Basis of Clinical Autoimmune Liver Diseases 1 Introduction to the Physiology, Immunology and Pathology of the Liver and Biliary Tree Liver Cell Types and Organization Hepatic Metabolism Hepatic Transport Systems Drug Metabolism Bile Formation, Secretion and the Enterohepatic Circulation Death and Regeneration of Hepatocytes Cholangiocyte Reaction to Biliary Damage Protective Role of Biliary HCO 3 −Secretion Cholangiocytes and Immunity Biochemical Markers and Patterns of Hepatic Injury References 2 Concepts of Autoimmunity Relevant to Autoimmune Liver Diseases Introduction Role of Innate and Adaptive Immunity in Autoimmunity in the Context of the Liver as an Immune Organ Generation and Maintenance of Tolerance to Self‐antigens Risk Factors for Autoimmune Diseases Loss of Immune Tolerance to Autoantigens and Perpetuation of Autoimmune Diseases Prevention of Autoimmunity and Therapeutic Control of Autoimmune Diseases References 3 Genetics and Risk of Autoimmune Liver Diseases Introduction HLA Associations in Autoimmune Liver Disease Non‐HLA Associations in Autoimmune Liver Disease Conclusion References 4 Autoantibodies and Understanding of Autoimmune Liver Diseases Introduction Methods of Detection Anti‐nuclear Antibody Anti‐smooth Muscle and Anti‐actin Antibodies Anti‐liver‐kidney Microsomal Antibody Anti‐liver Cytosol Type 1 Antibody Anti‐soluble Liver Antigen Antibody Anti‐neutrophil Cytoplasmic Antibody Anti‐mitochondrial Antibody Anti‐asialoglycoprotein Receptor Antibody Indications for Autoimmune Liver Serology Testing Concluding Remarks References 5 Environmental Exposure and Risk in Autoimmune Liver Diseases Introduction Autoimmunity Primary Biliary Cholangitis Autoimmune Hepatitis Prospectus References

7 Section II: Autoimmune Liver Diseases and Their Clinical Correlation 6 Autoimmune Hepatitis Introduction Definition and Pathophysiology Epidemiology Presentation Diagnosis Treatment Prognosis References 7 Primary Biliary Cholangitis Introduction and Definition Epidemiology Etiopathogenesis Clinical Presentation Diagnosis Natural History Disease Course in the UDCA Era Risk Stratification Treatment Complications of Liver Disease Useful Websites References 8 Primary Sclerosing Cholangitis Introduction Definition Adult PSC Juvenile Sclerosing Cholangitis Conclusion References 9 IgG4‐Related Liver and Biliary Disease Introduction and Historical Perspective Etiology and Pathogenesis of IgG4‐RD Incidence and Prevalence of IgG4‐RD Clinical Characteristics of IgG4‐related Hepatobiliary Disease Diagnostic Criteria, Histologic Features, and Approach to Diagnosis of IgG4‐related Hepatobiliary Disease Radiologic Characteristics of Hepatobiliary IgG4‐RD IgG4‐RD and Relationship with Malignancy Management and Treatment of Patients with IgG4‐RD Conclusions and Future Directions References

8 Section III: Specific Clinical Challenges 10 Managing Acute and Chronic Seronegative Liver Disease Introduction An Approach to Seronegative Acute Liver Failure Potential Causes of Seronegative ALF and Features that Suggest an Autoimmune Pathogenesis Clinical Features of Seronegative ALF Risk Stratification in Seronegative ALF Management of Seronegative ALF An Approach to Cryptogenic Chronic Liver Disease Conclusion References 11 Managing Pregnant Women with Autoimmune Liver Disease Introduction Fertility in AIH Pregnancy Outcomes in AIH Liver‐related Outcomes in Pregnancy Pregnancy in Cirrhosis Safety of Medication in Pregnancy Summary References 12 Bone Health in Patients with Autoimmune Liver Diseases Introduction Prevalence of Osteoporosis and Fractures Pathogenesis Assessment of Bone Disease Prevention and Treatment of Bone Loss Summary References

9 Section IV: Transplantation and Its Role in Autoimmune Liver Disease 13 Recurrent Autoimmune Liver Disease and Its Impact on Clinical Practice Introduction Primary Biliary Cholangitis Primary Sclerosing Cholangitis Autoimmune Hepatitis Conclusions References 14 Recurrent Autoimmune Liver Disease and its Scientific Significance Introduction Recurrence of PBC Recurrence of PSC Recurrence of AIH Concluding Remarks References

10 Section V: Controversies in Autoimmune Liver Diseases 15 Making Sense of Overlap and Crossover Syndromes Introduction General Considerations PBC/AIH Overlap Syndrome PSC/AIH Overlap Syndrome Liver Transplantation Conclusions References 16 The Role of Extrahepatic Autoimmunity in Autoimmune Liver Disease Introduction Epidemiology Autoimmune Thyroid Disease Sjögren Syndrome Systemic Sclerosis Systemic Lupus Erythematosus Rheumatoid Arthritis Celiac Disease Inflammatory Bowel Disease Conclusions Guidelines for Clinicians References 17 Symptoms, Chronic Disease, and Patient Management Background Goals of Treatment Symptoms, Quality of Life, and Health Utility: Key Concepts Symptoms and Their Management in AILD Effective Care Delivery in AILD References

11 Index

12 End User License Agreement

List of Tables

1 Chapter 2 Table 2.1 Comparison of classic autoimmunity with AIH, PBC or PSC. Table 2.2 Comparison of selected features of innate and adaptive immunity. Table 2.3 Current and future therapeutic approaches to control autoimmune dis...

2 Chapter 3 Table 3.1 Heritability of selected autoimmune or immune‐mediated disorders, m... Table 3.2 Genome‐wide association studies (GWAS) or related study designs o... Table 3.3 Genome‐wide association studies (GWAS) or related study designs ... Table 3.4 Genome‐wide association studies (GWAS) or related study designs o... Table 3.5 HLA locus associations in primary sclerosing cholangitis (PSC), prim... Table 3.6 Risk loci and candidate genes for primary biliary cholangitis.Table 3.7 Risk loci and candidate genes for primary sclerosing cholangitis.

Читать дальше
Тёмная тема
Сбросить

Интервал:

Закладка:

Сделать

Похожие книги на «Autoimmune Liver Disease»

Представляем Вашему вниманию похожие книги на «Autoimmune Liver Disease» списком для выбора. Мы отобрали схожую по названию и смыслу литературу в надежде предоставить читателям больше вариантов отыскать новые, интересные, ещё непрочитанные произведения.


Отзывы о книге «Autoimmune Liver Disease»

Обсуждение, отзывы о книге «Autoimmune Liver Disease» и просто собственные мнения читателей. Оставьте ваши комментарии, напишите, что Вы думаете о произведении, его смысле или главных героях. Укажите что конкретно понравилось, а что нет, и почему Вы так считаете.

x