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Edited by

James Neuberger

University Hospital BirminghamQueen Elizabeth HospitalEdgbastonBirmingham, UK

Gideon M. Hirschfield

University of TorontoTorontoOntario, Canada

This edition first published 2020 © 2020 by John Wiley & Sons Ltd

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Library of Congress Cataloging‐in‐Publication Data

Names: Neuberger, James, editor. | Hirschfield, Gideon M., editor.

Title: Autoimmune liver disease : management and clinical practice / edited by James Neuberger, University Hospital Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham, UK, Gideon M. Hirschfield, University of Toronto, Toronto, Ontario, Canada.

Description: Hoboken, NJ : Wiley‐Blackwell, 2020. | Includes bibliographical references and index.

Identifiers: LCCN 2019051484 (print) | LCCN 2019051485 (ebook) | ISBN 9781119532606 (hardback) | ISBN 9781119532613 (adobe pdf) | ISBN 9781119532620 (epub)

Subjects: LCSH: Liver–Diseases–Immunological aspects. | Autoimmune diseases.

Classification: LCC RC846 .A87 2020 (print) | LCC RC846 (ebook) | DDC 616.3/62079–dc23

LC record available at https://lccn.loc.gov/2019051484LC ebook record available at https://lccn.loc.gov/2019051485

Cover Design: Wiley

Cover Images: Immunofluorescence Microscopy © Beano5/Getty Images, Prostate Gland © BeholdingEye/Getty Images, PET CT scan © springsky/Shutterstock, Human organ liver © Marochkina Anastasiia/Shutterstock

Over the last three decades there have been many advances in the understanding of autoimmune liver disease (AILD). The advances in understanding the pathogenesis of these diseases is starting to lead to more specific therapies both for slowing or arresting progression and for treatment of the symptoms. Many people with AILD see delays in diagnosis and are misdiagnosed; treatments tend at best to control progression rather than induce resolution. Symptoms are often not treated because of either poor knowledge or inadequate therapies. Liver transplantation, a highly effective therapy for those with end‐stage disease, has its inherent risks and complications and is really a reflection of a failure to treat the original disease. Recurrence of AILD after transplantation, which manifests despite sufficient immunosuppression to prevent allograft rejection and in a foreign HLA milieu, must provide clues to some of the processes that lead to AILD but the lessons remain obscure.