Genomic and Epigenomic Biomarkers of Toxicology and Disease

Edited by

Saura C. Sahu

Formerly of Center for Food Safety and Applied Nutrition,US Food and Drug Administration,MD, USA

This edition first published 2022 © 2022 John Wiley & Sons Ltd

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1 Cover

2 Title page Genomic and Epigenomic Biomarkers of Toxicology and Disease Clinical and Therapeutic Actions Edited by Saura C. Sahu Formerly of Center for Food Safety and Applied Nutrition,US Food and Drug Administration,MD, USA

3 Copyright

4 Dedication

5 Preface

6 Acknowledgements

7 List of Contributors

8 1 Genomic and Epigenomic Biomarkers for Predictive Toxicity and Disease

9 2 MicroRNAs as Non-invasive Biomarkers of Toxicity and Chemical Hazard: Genomic and Epigenomic Biomarkers of Toxicology and Disease

10 3 EV (Extracellular Vesicle)-associated miRNAs as Biomarkers of Toxicity

11 4 Circulating miRNAs as Biomarkers of Toxic Heavy Metal Exposure

12 5 MicroRNA Biomarkers of Malignant Mesothelioma

13 6 Role of Non-coding RNAs in Innate Immune Responses Perturbed by Environmental Arsenic Exposure

14 7 Transcriptomics: Applications in Toxicology and Medicine

15 8 Network Biology for Biomarker Discovery and Therapy in Cancer

16 9 Epigenetic Biomarkers: Link to Maternal Exposure and Offspring Health Outcomes

17 10 The Role of Dynamic Epigenetic Changes in Modulating Homeostasis after Exposure to Low-dose Environmental Chemicals

18 11 Emerging Non-invasive Molecular Biomarkers for Early Cancer Detection

19 12 Aberrant DNA Methylation of Tumor Suppressor Genes and Oncogenes as Cancer Biomarkers

20 13 SMYD Protein Family as Promising Biomarkers for Cancer Diagnosis and Prognosis

21 14 Toward Precision Medicine: Epigenetic Alterations in Human Melanoma

22 15 Currents Trends and Future Perspectives in Our Epigenetic Signatures: What a Diet Can Trigger

23 16 Genetic and Epigenetic Biomarkers of Organophosphate Compounds, Dialkyl Phosphate Exposure, and Their Relation to Biological Effects

24 17 Genetic, Epigenetic, and Anatomical Factors in Agenesis and Development of Female Reproductive Tract

25 18 Cause or Consequence: Epigenomic DNA Methylation Changes in Arsenic-Mediated in Vitro Transformation of Human Prostate Cells

26 19 Epigenetic Regulation of Sex Determination and Toxicity in Nonmammalian Vertebrates

27 20 Characterization of Genomic and Epigenomic Biomarkers of Nanoparticle Toxicity Using the Zebrafish Model System

28 Index

29 End User License Agreement

1 Chapter 2Figure 2.1 Tissue-specific miRNAs in mammals. Human....

2 Chapter 3Figure 3.1 Schematic illustration of extracellular vesicles (EVs....Figure 3.2 Gel electrophoresis of mouse liver total....Figure 3.3 Canonical miRNA biogenesis pathway....Figure 3.5 Horizontal gene transfer mediated by EVs....Figure 3.6 (a) Schematic representation of the engineered....Figure 3.7 Schematic representation of toxicity testing using....Figure 3.8 Evaluation of EVs using NanoSight. Serum....Figure 3.9 Representative H&E micrographs of....Figure 3.10 Differentially expressed EV-associated miRNAs. Individual....

3 Chapter 4Figure 4.1 Major routes of exposure for heavy....Figure 4.2 Simplified overview of miRNA biogenesis and....Figure 4.3 Differential expression map of circulating miRNAs....Figure 4.4 Differential expression map of circulating miRNAs....

4 Chapter 6Figure 6.1 Comparison of innate immune system genes....Figure 6.2 Regulation of innate immune system responses....

5 Chapter 7Figure 7.1 Xenobiotic exposure to the disease development....Figure 7.2 Steps involved in the transcriptome analysis....Figure 7.3 Cytotoxicity and DGE profile in an....Figure 7.4 Biological functions enriched in response to....Figure 7.5 Crystalline silica-induced lung toxicity and....Figure 7.6 Biological functions enriched in response to....