Genomic and Epigenomic Biomarkers of Toxicology and Disease

6 Chapter 8Figure 8.1 Categories of the graph. a Undirected....Figure 8.2 Alterations in protein-protein interactions in....Figure 8.3 a OncoPPi network containing 83 lung....Figure 8.4 Construction and analysis of a co....Figure 8.5 Gene regulatory elements and the GRN....Figure 8.6 There are two categories of metabolic....Figure 8.7 Proteins associated with the same disease....Figure 8.7 Disease association of TSGs. a Bi....

7 Chapter 10Figure 10.1 The potential roles of epigenetic modifications....Figure 10.2 A schematic illustration of how low....

8 Chapter 13Figure 13.1 The SMYD protein family. S, S....Figure 13.1 SMYD proteins involved in cancer-promoting....

9 Chapter 14Figure 14.1 Estimated age-standardized incidence rates of....Figure 14.2 Post-translational changes in histones N....Figure 14.3 Classification of main types of non....Figure 14.4 Main molecular events in melanoma progression....

10 Chapter 15Figure 15.1 From nutritional factors to phenotype. The....Figure 15.2 The complex interrelationship between....Figure 15.3 The dynamics of epigenetics over generations....Figure 15.4 The direct and indirect consequences of....Figure 15.5 The role of diet in folic....Figure 15.6 The transgenerational effect of nutrients. The....Figure 15.7 The role of breastfeeding in the....Figure 15.8 The number of studies focused on....

11 Chapter 16Figure 16.1 General structure of an OP. R....Figure 16.2 (A) Dialkyl phosphate general formula; (B....Figure 16.3 DAP structures and pKa. Upper row....Figure 16.4 Toxic effects observed in human populations....Figure 16.5 Genetic and epigenetic effects of OP....

12 Chapter 17Figure 17.1 Genetic, epigenetic, and anatomical factors involved....Figure 17.2 The role of estrogen receptors (ESRs....

13 Chapter 18Figure 18.1 Experimental approach. DNA and RNA were....Figure 18.2 Differentially methylated bases (DMBs) and clusters....Figure 18.3 CpG coverage by BisDNA-seq. Reads....Figure 18.4 Epigenomic features of DNA methylation in....Figure 18.5 Increased gene methylation in arsenic-transformed....Figure 18.6 Increased methylation of CpG islands and....Figure 18.7 CpG sites for the validation of....Figure 18.8 Validation of BisDNA-seq methylation CpG....Figure 18.9 Association of gene methylation and expression....Figure 18.10 Specific genes with an inverse association....Figure 18.11 Genes showing an inverse association between....

14 Chapter 19Figure 19.1 Major epigenetic machineries. (A) DNA methylation....Figure 19.2 Sex determining cascades in non-mammalian....Figure 19.3 Modes of sex reversal among teleost....Figure 19.4 Sex reversal and inheritance of DNA....Figure 19.5 Phylogenetic relationship between reptiles and sex....Figure 19.6 Temperature-dependent regulation of dmrt1 in....Figure 19.7 Temperature-induced sex reversal in the....Figure 19.8 Epigenetic regulation of dmrt1 expression in....

15 Chapter 20Figure 20.1 Different -omics approaches applied in zebrafish....Figure 20.2 General outcomes of nanoparticle toxicity in....Figure 20.3 Major epigenetic alterations identified in the....Figure 20.4 Key pathways of neuronal toxicity induced....Figure 20.5 General routes of immunotoxicity....Figure 20.6 Reproductive toxicity outcomes identified....

1 Chapter 2 Table 2.1 Human studies on environmental toxicant-induced...

2 Chapter 3 Table 3.1 Main characteristics of exosomes...

3 Chapter 3 Table 3.2 Summary of exosomal proteins for early tumor diagnosis.

4 Chapter 3 Table 3.3 Summary of exosomal miRNAs for early tumor diagnosis.

5 Chapter 4 Table 4.1 Description of biomarker subtypes.

6 Chapter 6Table 6.1 Comparative Toxicogenomics Database’s top...

7 Chapter 6Table 6.2 Immune system pathways perturbed by exposure...

8 Chapter 6Table 6.3 Danio rerio macrophage and neutrophil specific....

9 Chapter 6Table 6.4 miRNAs associated with the innate immune...

10 Chapter 6Table 6.5 Arsenic perturbation of miRNAs associated...

11 Chapter 7Table 7.1 Fold changes in expressions of genes...

12 Chapter 7Table 7.2 Fold changes in expressions of genes...

13 Chapter 12Table 12.1 DNA methylation-based cancer biomarkers.

14 Chapter 13Table 13.1 Genetic alterations as biomarkers.

15 Chapter 13Table 13.2 SMYD overexpression as biomarker.

16 Chapter 13Table 13.3 SMYD3-mediated histone lysine methylation as biomarker.

17 Chapter 13Table 13.4 Non-histone lysine methylation as biomarker.

18 Chapter 14Table 14.1 Summary of the main risk factors...

19 Chapter 14Table 14.2 Types of immunotherapies currently...

20 Chapter 15Table 15.1 DMTs subtypes and their function.

21 Chapter 15Table 15.2 Epigenetic interference of food...

22 Chapter 16Table 16.1 Toxic effects associated to...

23 Chapter 17Table 17.1 List of candidate genes involved in the...

24 Chapter 18Table 18.1 Summary of differentially methylated clusters.

25 Chapter 20Table 20.1 A summary of selected nanomaterial...

26 Chapter 20Table 20.2 Hallmark features of nanoparticle...

1 Cover

2 Title page

3 Copyright

4 Dedication

5 Table of Contents

6 Preface

7 Acknowledgements

8 List of Contributors

9 Begin Reading

10 Index

11 End User License Agreement

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