Clinical Pharmacology and Therapeutics

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Edited by

Gerard A. McKay

Glasgow Royal Infirmary, NHS Greater Glasgow and Clyde

Glasgow, UK

Matthew R. Walters

College of Medical, Veterinary and Life Sciences

University of Glasgow

Glasgow, UK

Neil D. Ritchie

Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde

Glasgow, UK

Tenth Edition

This edition first published 2021

© 2021 John Wiley & Sons Ltd

Edition History Previous editions 1982, 1985, 1989, 1992, 1996, 2001, 2006, 2010, 2013

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Library of Congress Cataloging‐in‐Publication Data

Names: McKay, Gerard A., editor. | Walters, Matthew R., editor. | Ritchie, Neil D., (Of University of Glasgow), editor.

Title: Lecture notes. Clinical pharmacology and therapeutics / edited by Gerard A. McKay, Matthew R. Walters, Neil D. Ritchie.

Other titles: Clinical pharmacology and therapeutics

Description: 10th edition. | Hoboken, NJ : Wiley‐Blackwell, 2021. | Includes bibliographical references and index.

Identifiers: LCCN 2020028787 (print) | LCCN 2020028788 (ebook) | ISBN 9781119599951 (paperback) | ISBN 9781119599968 (adobe pdf) | ISBN 9781119599975 (epub)

Subjects: MESH: Pharmacological Phenomena | Pharmacology, Clinical–methods | Drug Therapy–methods

Classification: LCC RM300 (print) | LCC RM300 (ebook) | NLM QV 37 | DDC 615.1–dc23

LC record available at https://lccn.loc.gov/2020028787LC ebook record available at https://lccn.loc.gov/2020028788

Cover Design: Wiley

Cover Image: © apomares/Getty Images

The successful practice of Medicine is predicated upon the ability to use drugs safely and effectively. This ability can be difficult to acquire and needs to be maintained as the range of drugs available to alleviate symptoms and to treat disease is constantly growing. As our understanding of the genome, and of the molecular basis of disease has increased, the development of new drugs with novel mechanisms of action has accelerated, expanding the available pharmacopeia for clinicians from all disciplines and therapeutic areas.

As our knowledge evolves, so must our textbooks. This tenth edition of Lecture Notes in Clinical Pharmacology has been extensively revised, refreshed and updated to provide the reader with an authoritative and modern insight into the use of drugs in the treatment of human disease.

Although the range of drugs available has expanded hugely since the first edition of this book was published almost 40 years ago, in preparing this text we continue to be guided by the principles established in that edition: we have retained a clear focus on practical elements and clinical relevance throughout, in order to maximise utility for the student or practising clinician. Rather than indulgence in exhaustive detail, we have chosen to set out concisely and with clarity the principles which guide clinicians in their choices and have made use of illustrative examples from scenarios commonly encountered on wards and in clinics. In doing so, we hope to provide the reader with an accessible and helpful guide which imparts a useful understanding of not only how, but also when to use drugs.

Gerard A. McKay

Neil D. Ritchie

Matthew R. Walters

Glasgow