Clinical Pharmacology and Therapeutics

8 Chapter 9Table 9.1 Examples of antimicrobials for which dose modification or caution i...Table 9.2 Examples of antimicrobials for which therapeutic concentrations are...Table 9.3 Major adverse reactions of antimicrobial drugs.Table 9.4 Examples of empirical antibiotic therapy for adults.Table 9.5 Approved antiretroviral drugs in the UK (2019).Table 9.6 Examples of important drug interactions with NNRTIs and PIs.Table 9.7 Combination tablets available in the UK (2019).Table 9.8 Direct acting antivirals by class.Table 9.9 Fixed dose DAA treatments for HCV.

9 Chapter 10Table 10.1 Aspects for consideration in the management of diabetes.Table 10.2 Common drug treatments for type 2 diabetes mellitus.Table 10.3 Insulin formulations.Table 10.4 Adverse effects of insulin therapy.Table 10.5 Pharmacokinetics of GLP‐1 receptor agonists.Table 10.6 Pharmacokinetics of DPP‐4 inhibitors.Table 10.7 Cardiovascular outcomes trials in type 2 diabetes.Table 10.8 Suggested potassium regimen in patients with diabetic ketoacidosis...Table 10.9 Treatments used in the management of thyrotoxicosis.Table 10.10 Vitamin D preparations and their use.Table 10.11 Bisphosphonates.

10 Chapter 11Table 11.1 Situations where combined hormonal contraception is not recommende...

11 Chapter 12Table 12.1 Examples of some targeted therapies and tumour sites where they ar...

12 Chapter 13Table 13.1 Target international normalised ratios (INR) for warfarin anticoag...Table 13.2 Important drug interactions with warfarin.Table 13.3 Reversal of warfarin anticoagulation.

13 Chapter 15Table 15.1 Summary of TNF inhibitors in current clinical use.

14 Chapter 16Table 16.1 Scheme for helping to make risk assessments on the need for prophy...Table 16.2 Current vaccines available in the UK.Table 16.3 Approximate time interval required for maximum protection after pr...Table 16.4 Antimalarial drugs.Table 16.5 Selected parasitic infections of medical importance.

15 Chapter 17Table 17.1 Pain fibre properties.Table 17.2 Types of pain.Table 17.3 Classification of commonly prescribed NSAIDs.Table 17.4 Opioid classification.Table 17.5 Common causes of pain in ICU.Table 17.6 Properties of vasopressors and inotropes.

16 Chapter 18Table 18.1 Ten commonest drugs associated with NPIS enquiries in the UK via T...Table 18.2 Poisons information services.Table 18.3 Examples of symptoms associated with specific toxins.Table 18.4 The AVPU scale.Table 18.5 Agents not adsorbed by charcoal.Table 18.6 List of antidotes and their mechanism of action.

1 Chapter 1 Figure 1.1 Schematic examples of a drug (a) with a steep dose– (or concentra... Figure 1.2 Schematic diagram of the dose–response relationship for the desir... Figure 1.3 Steady‐state concentration–time profile for an oral dose (—) and ... Figure 1.4 Plot of concentration versus time after a bolus intravenous injec... Figure 1.5 Plot of concentration versus time illustrating the accumulation t... Figure 1.6 Semi‐logarithmic plot of concentration versus time after a bolus ...

2 Chapter 3 Figure 3.1 The concept of quality‐adjusted life year (QALY). Figure 3.2 Incremental cost‐effectiveness ratio.

3 Chapter 4 Figure 4.1 Example community prescription conforming to the principles outli... Figure 4.2 Examples of hospital prescription chart prescribing, including so...

4 Chapter 9Figure 9.1 Antibiotic drugs licenced in the United States by year of marketi...Figure 9.2 Mechanism of action of HIV drugs.Figure 9.3 Overview of the life cycle and genome of hepatitis C.

5 Chapter 10Figure 10.1 The main actions of insulin.Figure 10.2 Some examples of insulin dose–response curves.Figure 10.3 Management of patients with a new diagnosis of type 1 diabetes....

6 Chapter 11Figure 11.1 Mechanism of action – 5‐ α ‐reductase inhibitors. In most t...Figure 11.2 Action of Botox at the neuromuscular junction. Botox prevents fu...Figure 11.3 Hypothalamic–pituitary–gonadal axis. Hormonal control of the mal...Figure 11.4 Mechanism of action – phosphodiesterase inhibitors. Nitric oxide...

7 Chapter 12Figure 12.1 Mechanism of action of cytotoxic drugs.Figure 12.2 Simplified diagram of T cell and tumour cell interaction via TCR...

8 Chapter 13Figure 13.1 The coagulation cascade.Figure 13.2 The fibrinolytic system. Exogenous thrombolytic agents are plasm...

9 Chapter 16Figure 16.1 Areas requiring malaria prevention.

10 Chapter 17Figure 17.1 WHO pain ladder.

11 Chapter 18Figure 18.1 Paracetamol treatment graph.

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2 Table of Contents

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