Surya K. De - Applied Organic Chemistry

10 2 Condensation Reaction Aldol Condensation Reaction Mukaiyama Aldol Reaction Evans Aldol Reaction Henry Reaction Benzoin Condensation Claisen Condensation Darzens Glycidic Ester Condensation Dieckmann Condensation Knoevenagel Condensation Pechmann Condensation (synthesis of coumarin) (also called von Pechmann condensation) Perkin Condensation or Reaction Stobbe Condensation References Mukaiyama Aldol Reaction Evans Aldol Reaction Henry Reaction Benzoin Condensation Claisen Condensation Darzens Glycidic Ester Condensation Dieckmann Condensation Knoevenagel Condensation Pechmann Condensation Perkin Condensation or Reaction Stobbe Condensation

11 3 Olefination, Metathesis, and Epoxidation ReactionsOlefination Horner–Wadsworth–Emmons Reaction Julia–Lythgoe Olefination Julia–Kocienski Olefination Kauffmann Olefination Peterson Olefination Petasis Olefination Tebbe Olefination Wittig Reaction or Olefination Metathesis Asymmetric Epoxidation Sharpless Asymmetric Aminohydroxylation Woodward cis‐Dihydroxylation Prévost trans‐Dihydroxylation Reaction References Horner–Wadsworth–Emmons Reaction Julia–Lythgoe Olefination Julia–Kocienski Olefination Kauffmann Olefination Peterson Olefination Petasis Olefination Tebbe Olefination Wittig Reaction or Olefination Metathesis Sharpless Asymmetric Epoxidation Jacobsen–Katsuki Asymmetric Epoxidation Shi Asymmetric Epoxidation Sharpless Asymmetric Dihydroxylation Sharpless Asymmetric Aminohydroxylation Woodward cis‐Dihydroxylation Prévost trans‐Dihydroxylation Reaction

12 4 Miscellaneous ReactionsAlder‐Ene Reaction Appel Reaction Barton Decarboxylation Barton Nitrite Photolysis (Barton nitrite ester reaction) Brown Hydroboration Bucherer Reaction Chichibabin Reaction Chugaev Elimination Reaction Cannizzaro Reaction Cope Elimination Reaction Corey–Fuchs Reaction Corey–Nicolaou Macrolactonization Danheiser Annulation Danheiser Benzannulation Diels–Alder Reaction Dutt–Wormall Reaction Étard Reaction Finkelstein Reaction Fischer–Speier Esterification Mukaiyama Esterification Yamaguchi Esterification Grignard Reaction Gabriel Synthesis Hell–Volhard–Zelinsky Reaction Hofmann Elimination or Exhaustive Methylation Hosomi–Sakurai Reaction Huisgen Cycloaddition Reaction Hunsdiecker Reaction Keck Asymmetric Allylation Thionation Reaction (Lawesson's Reagent) Michael Addition or Reaction Mitsunobu Reaction Morita–Baylis–Hillman Reaction (Baylis–Hillman Reaction) Nozaki–Hiyama–Kishi Reaction Paterno–Büchi Reaction Pauson–Khand Reaction Reformatsky Reaction Ritter Reaction Robinson Annulation Sandmeyer Reaction Schotten–Baumann Reaction Simmons–Smith Reaction Stork Enamine Synthesis Tishchenko Reaction Ullmann Coupling or Biaryl Synthesis Ullmann Biaryl Ether and Biaryl Amine Synthesis/Ullman Condensation Weinreb Ketone Synthesis Williamson Ether Synthesis Wurtz Coupling or Reaction Wurtz–Fittig Reaction References Appel Reaction Barton Decarboxylation Barton Nitrite Photolysis (Barton Nitrite Ester Reaction) Brown Hydroboration Bucherer Reaction Chichibabin Reaction Chugaev Elimination Reaction Cannizzaro Reaction Cope Elimination Reaction Corey–Fuchs Reaction Corey–Nicolaou Macrolactonization Danheiser Annulation/Danheiser Benzannulation Diels–Alder Reaction Dutt–Wormall Reaction Étard Reaction Finkelstein Reaction Fischer–Speier Esterification Mukaiyama Esterification Yamaguchi Esterification Grignard Reaction Gabriel Synthesis Hell–Volhard–Zelinsky Reaction Hofmann Elimination or Exhaustive Methylation Hosomi–Sakurai Reaction Huisgen Cycloaddition Reaction/Click Chemistry Hunsdiecker Reaction Keck Asymmetric Allylation Thionation Reaction (Lawesson's Reagent) Michael Addition or Reaction Mitsunobu Reaction Morita–Baylis–Hillman Reaction (Baylis–Hillman Reaction) Nozaki–Hiyama–Kishi Reaction Paterno–Büchi Reaction Pauson–Khand Reaction Reformatsky Reaction Ritter Reaction Robinson Annulation Sandmeyer Reaction Schotten–Baumann Reaction Simmons–Smith Reaction Stork Enamine Synthesis Tishchenko Reaction Ullmann Coupling or Biaryl Synthesis Ullmann Biaryl Ether and Biaryl Amine Synthesis/Ullman Condensation Weinreb Ketone Synthesis Williamson Ether Synthesis Wurtz Coupling or Reaction Wurtz–Fittig Reaction

13 5 Aromatic Electrophilic Substitution ReactionsBardhan–Sengupta Synthesis Bogert–Cook Reaction or Synthesis of Phenanthrene Friedel–Crafts Reaction Gattermann Aldehyde Synthesis Gattermann–Koch Aldehyde Synthesis Haworth Reaction Houben–Hoesch Reaction Kolbe–Schmitt Reaction Reimer–Tiemann Reaction Vilsmeier–Haack Reaction References Bogert–Cook Reaction or Synthesis of Phenanthrene Friedel–Crafts Reaction Gattermann Aldehyde Synthesis Gattermann–Koch Aldehyde Synthesis Haworth Reaction Houben–Hoesch Reaction Kolbe–Schmitt Reaction Reimer–Tiemann Reaction Vilsmeier–Haack Reaction

14 6 Pd‐Catalyzed C C Bond‐Forming ReactionsSuzuki Coupling Reaction Heck Coupling Reaction (Mizoroki–Heck Reaction) Negishi Coupling Reaction Stille Coupling Reaction (Migita–Kosugi–Stille Coupling Reaction) Sonogashira Coupling Reaction Kumada Cross‐Coupling Hiyama Coupling Reaction Liebeskind–Srogl Coupling Reaction Fukuyama Coupling Reaction Buchwald–Hartwig Coupling Reaction (Buchwald–Hartwig Amination) Tsuji–Trost Allylation References Heck Coupling Reaction (Mizoroki–Heck Reaction) Negishi Coupling Reaction Stille Coupling Reaction (Migita–Kosugi–Stille Coupling Reaction) Sonogashira Coupling Reaction Kumada Cross‐Coupling Hiyama Coupling Reaction Liebeskind–Srogl Coupling Reaction Fukuyama Coupling Reaction Buchwald–Hartwig Coupling Reaction (Buchwald–Hartwig Amination) Tsuji–Trost Allylation

15 7 Multicomponent Reaction Biginelli Reaction (3‐Component Reaction [3‐CR]) Gewald Reaction (3‐Component Reaction [3‐CR]) Hantzsch Pyridine Synthesis Mannich Reaction Passerini Reaction (3‐Component Reaction [3‐CR]) Strecker Amino Acid Synthesis Ugi Reaction (4‐Component Reaction [4‐CR]) Asinger Reaction (4‐Component Reaction [A‐4CR]) References Gewald Reaction Hantzsch Pyridine Synthesis Mannich Reaction Passerini Reaction Strecker Amino Acid Synthesis Ugi Reaction Asinger Reaction

16 8 Oxidations and ReductionsOxidation Reactions Dess–Martin Oxidation Jones Oxidation Swern Oxidation Pfitzner–Moffatt Oxidation Tamao–Fleming Oxidation Tamao–Kumada Oxidation Oppenauer Oxidation Riley Oxidation Ley–Griffith Oxidation Criegee Oxidation (Criegee Glycol Cleavage) Criegee Ozonolysis Reduction Reactions Bouveault–Blanc Reduction Clemmensen Reduction Corey–Bakshi–Shibata Reduction (also known as Itsuno–Corey reduction) Noyori Asymmetric Hydrogenation Luche Reduction Meerwein–Ponndorf–Verley Reduction Mozingo Reduction Rosenmund Reduction Wolff–Kishner Reduction References Dess–Martin Oxidation Jones Oxidation Swern Oxidation Pfitzner–Moffatt Oxidation Tamao–Fleming Oxidation Tamao–Kumada Oxidation Oppenauer Oxidation Riley Oxidation Ley–Griffith Oxidation Criegee Oxidation (Criegee Glycol Cleavage) Criegee Ozonolysis Birch Reduction Bouveault–Blanc Reduction Clemmensen Reduction Corey–Bakshi–Shibata Reduction (also known as Itsuno–Corey Reduction) Noyori Asymmetric Hydrogenation Luche Reduction Meerwein–Ponndorf–Verley Reduction Mozingo Reduction Rosenmund Reduction Wolff–Kishner Reduction

17 9 Nomenclature and Application of Heterocyclic Compounds The Hantzsch–Widman Nomenclature Common Names The Replacement Nomenclature Application of Heterocyclic Compounds Drugs for Oxirane Derivatives Drugs for Aziridine Derivatives Drugs for Azetidine Derivatives Drugs for Oxetane Derivatives Drugs for Furan Derivatives Drugs for Thiophene Derivatives Drugs for Pyrrole and Pyrrolidine Derivatives Drugs for Imidazole, Imidazoline, and Imidazolidine Derivatives Drugs for Triazole Derivatives Drugs for Isoxazole Derivatives Drugs for Thiazole Derivatives Drugs for Pyridine Derivatives Drugs for Pyrimidine Derivatives Drugs for Pyrazine Derivatives Drugs for Piperidine Derivatives Drugs for Quinoline/Isoquinoline Derivatives Drugs for Oxazole/Isoxazole/Thiazole/Thiadiazole Derivatives Drugs for Chromane Derivatives Drugs for Indole Derivatives Drugs for Benzimidazole Derivatives Drugs for Indazole Derivatives Drugs for Azepin/Diazepine Derivatives Drugs for Xanthine Derivatives Drugs for Lactone Derivatives Drugs for β‐Lactam Derivatives References