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Edited by

Ramon Rios Torres

University of Southampton

Southampton, United Kingdom

This edition first published 2022

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Library of Congress Cataloging-in-Publication Data

Names: Riós Torres, Ramón, author.

Title: Spiro compounds : synthesis and applications / Ramon Rios Torres, University of Southampton, Southhampton, United Kingdom.

Description: First edition. | Hoboken, NJ : Wiley, 2022. | Includes index.

Identifiers: LCCN 2021031988 (print) | LCCN 2021031989 (ebook) | ISBN 9781119567639 (hardback) | ISBN 9781119567622 (adobe pdf) | ISBN 9781119567653 (epub)

Subjects: LCSH: Organic compounds–Structure.

Classification: LCC QD255.4 .R56 2022 (print) | LCC QD255.4 (ebook) | DDC 547/.5–dc23

LC record available at https://lccn.loc.gov/2021031988LC ebook record available at https://lccn.loc.gov/2021031989

Cover Design: Wiley

Cover Image: © Connect world/Shutterstock

Vikas R. AswarDepartment of Chemistry, Indian Institute of Technology Bombay, Mumbai, India

Lu BaiKey Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry & Materials Science, Northwest University, Xi’an, China

Matthias BaudSchool of Chemistry and Institute for Life Sciences, University of Southampton, Southampton, UK

Hak‐Fun ChowDepartment of Chemistry, Institute of Molecular Functional Materials and The Center of Novel Functional Molecules, The Chinese University of Hong Kong, Shatin, Hong Kong

Xavier CompanyóDepartment of Chemical Sciences, University of Padova, Padova, PD, Italy

Xiao‐Yuan CuiSchool of Chemistry and Molecular Engineering, East China Normal University, Shanghai, China

Luca Dell’AmicoDepartment of Chemical Sciences, University of Padova, Padova, PD, Italy

Sambasivarao KothaDepartment of Chemistry, Indian Institute of Technology Bombay, Mumbai, India

Dietmar KuckDepartment of Chemistry and Center for Molecular Materials (CM2), Bielefeld University, Bielefeld, Germany

Jingjing LiuKey Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry & Materials Science, Northwest University, Xi’an, China

Xinjun LuanKey Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry & Materials Science, Northwest University, Xi’an, China

Marta MeazzaSchool of Chemistry, University of Southampton, Southampton, UK

Albert MoyanoSecció de Química Orgànica, Departament de Química Inorgànica i Orgànica, Facultat de Química, Universitat de Barcelona, Barcelona, Catalonia, Spain

Suva PariaDepartment of Chemical Sciences, University of Padova, Padova, PD, Italy

Ramon RiosDepartment of Organic Chemistry, University of Southampton, Southampton, UK

Yellaiah TangellaDepartment of Chemistry, Indian Institute of Technology Bombay, Mumbai, India

Alberto Vega‐PeñalozaDepartment of Chemical Sciences, University of Padova, Padova, PD, Italy

Jan VeselýDepartment of Organic Chemistry, Faculty of Science, Charles University, Prague, Czech Republic

Michal UrbanDepartment of Organic Chemistry, Faculty of Science, Charles University, Prague, Czech Republic

Peng‐Wei XuSchool of Chemistry and Molecular Engineering, East China Normal University, Shanghai, China

Jin‐Sheng YuSchool of Chemistry and Molecular Engineering, East China Normal University, Shanghai, China

Jian ZhouSchool of Chemistry and Molecular Engineering, East China Normal University, Shanghai, China

When I was a kid, I dreamt to be an engineer and build planes, cars, etc. However, in high school, I felt in love with Organic Chemistry. I changed my dreams of building things for how to assemble C, H, N, and other atoms to form molecules. I was always astonished of the inherent difficulty of organicstructures, not only for their diversity and ordered assembly but also for their 3D shape. With time, I enjoyed learning Organic Chemistry: starting from my bachelor in organic chemistry, followed by a PhD in organometallic chemistry, and several postdocs in organometallic chemistry and organocatalysis. Later on, as academic, I have always tried to develop new reactions that can allow to obtain difficult structures in an enantiopure form. However, one of the greatest challenges that I faced has been the synthesis of spiro compounds. My own way to be interested in the synthesis of spiro compounds first started in the synthesis of quaternary carbons in an enantiopure fashion. Precisely, while studying how to synthesize quaternary carbons, I developed an interest in spiro compounds, how difficult it will be to join two cycles by a single atom, and do it enantioselectively. In my research group, we have been lucky enough to develop several reactions that led to spiro compounds in an enantiopure form (or almost enantiopure), but I still remember the first time that we got a spiro compound in an enantiopure form as an incredible feeling of achievement. Now, several years later, I decided to honor this type of compounds by editing a book, summarizing the achievements that Organic Chemists have been done in the last decades.