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388 a1

Edited by

Evgeny Katz

Editor

Dr. Evgeny Katz

Clarkson University

Department of Chemistry

Clarkson Avenue 8

NY

United States

All books published by Wiley‐VCHare carefully produced. Nevertheless, authors, editors, and publisher do not warrant the information contained in these books, including this book, to be free of errors. Readers are advised to keep in mind that statements, data, illustrations, procedural details or other items may inadvertently be inaccurate.

Library of Congress Card No.:

applied for

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A catalogue record for this book is available from the British Library.

Bibliographic information published by the Deutsche Nationalbibliothek

The Deutsche Nationalbibliothek lists this publication in the Deutsche Nationalbibliografie; detailed bibliographic data are available on the Internet at < http://dnb.d-nb.de>.

© 2021 WILEY‐VCH GmbH, Boschstr. 12, 69469 Weinheim, Germany

All rights reserved (including those of translation into other languages). No part of this book may be reproduced in any form – by photoprinting, microfilm, or any other means – nor transmitted or translated into a machine language without written permission from the publishers. Registered names, trademarks, etc. used in this book, even when not specifically marked as such, are not to be considered unprotected by law.

Print ISBN:978‐3‐527‐34720‐9

ePDF ISBN:978‐3‐527‐82540‐0

ePub ISBN:978‐3‐527‐82541‐7

oBook ISBN:978‐3‐527‐82542‐4

Cover DesignAdam‐Design, Weinheim, Germany

The use of biomolecular systems for processing information, performing logic operations, computational operations, and even automata performance is a rapidly developing research area. The entire field was named with the general buzzwords, “biomolecular computing” or “biocomputing.” Exciting advances in the area include the use of various biomolecular systems including proteins/enzymes, DNA, RNA, DNAzymes, antigens/antibodies, and even whole biological (usually microbial) cells operating as “hardware” for unconventional computing. The present book concentrates on DNA and RNA molecules utilized for information processing (biocomputing). Extensive ongoing research in the DNA‐ and RNA‐based biocomputing has been motivated by speeding up computation, at least for solving some special problems, due to massive parallel operation of numerous biomolecules. The advantages of the DNA and RNA computing systems are also in their ability to operate in a biological environment for solving biomedical problems in terms of diagnostics and possibly therapeutic action, operating as nanorobots in living organisms. DNA molecules are also applicable as memory material with extremely high data density storage.

The present book summarizes research efforts of many groups in different universities and countries. The book reviews and exemplifies these developments, as well as offering an outlook for possible future research foci. The various topics covered highlight key aspects and the future perspectives of the DNA‐ and RNA‐based computing. The different topics addressed in this book will be of high interest to the interdisciplinary community active in the area of unconventional biocomputing. The readers can find additional complementary material on molecular [1], biomolecular [2], and enzyme‐based [3] computing published recently by Wiley‐VCH (see book cover pages below). It is hoped that the present book will be important and beneficial for researchers and students working in various areas related to biochemical computing, including biochemistry, materials science, computer science, and so on. Furthermore, the book is aimed to attract young scientists and introduce them to the field while providing newcomers with an enormous collection of literature references. I, indeed, hope that the book will spark the imagination of scientists to further develop the topic.

I would like to conclude this preface by thanking my wife Nina for her support in every respect in the past 49 years. Without her help it would not have been possible to complete this work. Also, cooperation and hard work of all authors working together with me on this edited volume are highly appreciated.

Potsdam, NY, USA

January 2020

Evgeny Katz