Individual Participant Data Meta-Analysis

Здесь есть возможность читать онлайн «Individual Participant Data Meta-Analysis» — ознакомительный отрывок электронной книги совершенно бесплатно, а после прочтения отрывка купить полную версию. В некоторых случаях можно слушать аудио, скачать через торрент в формате fb2 и присутствует краткое содержание. Жанр: unrecognised, на английском языке. Описание произведения, (предисловие) а так же отзывы посетителей доступны на портале библиотеки ЛибКат.

Individual Participant Data Meta-Analysis: краткое содержание, описание и аннотация

Предлагаем к чтению аннотацию, описание, краткое содержание или предисловие (зависит от того, что написал сам автор книги «Individual Participant Data Meta-Analysis»). Если вы не нашли необходимую информацию о книге — напишите в комментариях, мы постараемся отыскать её.

Individual Participant Data Meta-Analysis: A Handbook for Healthcare Research Split into five parts, the book chapters take the reader through the journey from initiating and planning IPD projects to obtaining, checking, and meta-analysing IPD, and appraising and reporting findings. The book initially focuses on the synthesis of IPD from randomised trials to evaluate treatment effects, including the evaluation of participant-level effect modifiers (treatment-covariate interactions). Detailed extension is then made to specialist topics such as diagnostic test accuracy, prognostic factors, risk prediction models, and advanced statistical topics such as multivariate and network meta-analysis, power calculations, and missing data.
Intended for a broad audience, the book will enable the reader to:
Understand the advantages of the IPD approach and decide when it is needed over a conventional systematic review Recognise the scope, resources and challenges of IPD meta-analysis projects Appreciate the importance of a multi-disciplinary project team and close collaboration with the original study investigators Understand how to obtain, check, manage and harmonise IPD from multiple studies Examine risk of bias (quality) of IPD and minimise potential biases throughout the project Understand fundamental statistical methods for IPD meta-analysis, including two-stage and one-stage approaches (and their differences), and statistical software to implement them Clearly report and disseminate IPD meta-analyses to inform policy, practice and future research Critically appraise existing IPD meta-analysis projects Address specialist topics such as effect modification, multiple correlated outcomes, multiple treatment comparisons, non-linear relationships, test accuracy at multiple thresholds, multiple imputation, and developing and validating clinical prediction models Detailed examples and case studies are provided throughout.

Individual Participant Data Meta-Analysis — читать онлайн ознакомительный отрывок

Ниже представлен текст книги, разбитый по страницам. Система сохранения места последней прочитанной страницы, позволяет с удобством читать онлайн бесплатно книгу «Individual Participant Data Meta-Analysis», без необходимости каждый раз заново искать на чём Вы остановились. Поставьте закладку, и сможете в любой момент перейти на страницу, на которой закончили чтение.

Тёмная тема
Сбросить

Интервал:

Закладка:

Сделать

11 Chapter 12Figure 12.1 Simulation‐based power estimates (based on 10,000 replications) ...Figure 12.2 Simulation‐based power estimates (based on 10,000 replications) ...Figure 12.3 Simulation‐based power estimates for the planned two‐stage IPD m...Figure 12.4 Predictive distribution for the true treatment effect in a new P...

12 Chapter 13Figure 13.1 Scatterplot of 10,000 pairs of treatment effect estimates on sys...Figure 13.2 Relationship between the observed treatment effect estimates on ...Figure 13.3 Forest plot comparing the summary treatment effect results and p...Figure 13.4 Relationship between the observed treatment effect estimates on ...Figure 13.5 Comparison of summary meta‐analysis results for outcome 1 in the...

13 Chapter 14Figure 14.1 Visual representation of direct and indirect evidence toward the...Figure 14.2 Network map of the direct comparisons available in the 28 trials...Figure 14.3 Extended forest plot showing the thrombolytics network meta‐anal...Figure 14.4 Plots of the ranking probability for each treatment considered i...Figure 14.5 Ranking of antimanic drugs for response and acceptability, based...Figure 14.6 The UNCOVER 228,229and FIXTURE 227trials form a network of six t...Figure 14.7 Average treatment effect estimates at the population level, for ...

14 Chapter 15Figure 15.1 Summary receiver operating characteristic (ROC) curves for the d...Figure 15.2 Confidence and prediction regions following application of model...Figure 15.3 Predictive (posterior) distributions for the true sensitivity an...Figure 15.4 Results of an IPD meta‐analysis of 29 studies (6725 participants...Figure 15.5 Histograms showing the observed distributions of ear temperature...Figure 15.6 Summary normal distribution for the fever and non‐fever groups b...Figure 15.7 Summary ROC curves when applying the conventional bivariate mode...

15 Chapter 16Figure 16.1 Forest plot showing the study estimates and IPD meta‐analysis re...Figure 16.2 Non‐linear prognostic relationship between temperature and relat...Figure 16.3 IPD meta‐analysis to examine whether glucose is a prognostic fac...Figure 16.4 Summary of the relationship between MVD and mortality rate, acco...Figure 16.5 Summary estimate and 95% confidence interval (CI) for the relati...Figure 16.6 Prognostic effect of BMI for subsequent cardiovascular disease, ...Figure 16.7 Contour‐enhanced funnel plot of the 31 studies included in the m...

16 Chapter 17Figure 17.1 Examples of the calibration performance of a logistic regression...Figure 17.2 Forest plot showing study‐specific and IPD meta‐analysis results...Figure 17.3 Meta‐regression showing a strong association between the observe...Figure 17.4 Summary estimates (and 95% CIs) of standardised and unstandardis...Figure 17.5 Overall calibration performance of a prognostic model for breast...Figure 17.6 Overall *calibration performance of a prediction model for morta...Figure 17.7 Calibration of QRISK2 and the Framingham risk score in women age...Figure 17.8 Forest plot of summary calibration slopes for different predicti...Figure 17.9 Calibration plots for models predicting late‐onset pre‐eclampsia...Figure 17.10 Top panel: Summary and predicted decision curves for diagnosing...

17 Chapter 18Figure 18.1 Options to analysing multiple imputation datasets in an IPD meta...Figure 18.2 IPD meta‐analysis of 10 studies examining the prognostic effect ...Figure 18.3 Summary results from a one‐stage IPD meta‐analysis of the GREAT ...Figure 18.4 MCMC sampling chain for the beta corresponding to history of dia...

Guide

1 Cover Page

2 Series Page

3 Title Page

4 Copyright Page

5 Dedication Page

6 Acknowledgements

7 Table of Contents

8 Begin Reading

9 Index

10 Wiley End User License Agreement

Pages

1 ii

2 iii

3 iv

4 v

5 ix

6 1

7 2

8 3

9 4

10 5

11 6

12 7

13 9

14 10

15 11

16 12

17 13

18 14

19 15

20 16

21 17

22 18

23 19

24 21

25 22

26 23

27 24

28 25

29 26

30 27

31 28

32 29

33 30

34 31

35 32

36 33

37 34

38 35

39 36

40 37

41 38

42 39

43 40

44 41

45 42

46 43

47 45

48 46

49 47

50 48

51 49

52 50

53 51

54 52

55 53

56 54

57 55

58 56

59 57

60 58

61 59

62 60

63 61

64 62

65 63

66 64

67 65

68 66

69 67

70 68

71 69

72 70

73 71

74 72

75 73

76 74

77 75

78 76

79 77

80 78

81 79

82 80

83 81

84 82

85 83

86 84

87 85

88 86

89 87

90 89

91 90

92 91

93 92

94 93

95 94

96 95

97 96

98 97

99 98

100 99

101 100

102 101

103 102

104 103

105 104

106 105

107 106

108 107

109 108

110 109

111 110

112 111

113 112

114 113

115 114

116 115

117 116

118 117

119 118

120 119

121 120

122 121

123 122

124 123

125 124

126 125

127 127

128 128

129 129

130 130

131 131

132 132

133 133

134 134

135 135

136 136

137 137

138 138

139 139

140 140

141 141

142 142

143 143

144 144

145 145

146 146

147 147

148 148

149 149

150 150

151 151

152 152

153 153

154 154

155 155

156 156

157 157

158 158

159 159

160 160

161 161

162 162

163 163

164 164

165 165

166 166

167 167

168 168

169 169

170 170

171 171

172 172

173 173

174 174

175 175

176 176

177 177

178 178

179 179

180 180

181 181

182 182

183 183

184 184

185 185

186 186

187 187

188 188

189 189

190 190

191 191

192 192

193 193

194 194

195 195

196 196

197 197

198 198

199 199

200 200

201 201

202 202

203 203

204 204

205 205

206 206

207 207

208 208

209 209

210 210

211 211

212 212

213 213

214 214

215 215

216 216

217 217

218 219

219 220

220 221

221 222

222 223

223 224

224 225

225 226

226 227

227 228

228 229

229 230

230 231

231 232

232 233

233 234

234 235

235 237

236 239

237 240

238 241

239 242

240 243

241 244

242 245

243 246

244 247

245 248

246 249

247 250

248 251

249 253

250 254

251 255

252 256

253 257

254 258

255 259

256 260

257 261

258 262

259 263

260 264

261 265

262 266

263 267

264 268

265 269

266 270

267 271

268 272

269 273

270 274

271 275

272 276

273 277

274 278

275 279

276 280

277 281

278 282

279 283

280 285

281 286

282 287

283 288

284 289

285 291

286 293

287 294

288 295

289 296

290 297

291 298

292 299

293 300

294 301

295 302

296 303

297 304

298 305

299 306

300 307

301 308

302 309

303 311

304 312

Читать дальше
Тёмная тема
Сбросить

Интервал:

Закладка:

Сделать

Похожие книги на «Individual Participant Data Meta-Analysis»

Представляем Вашему вниманию похожие книги на «Individual Participant Data Meta-Analysis» списком для выбора. Мы отобрали схожую по названию и смыслу литературу в надежде предоставить читателям больше вариантов отыскать новые, интересные, ещё непрочитанные произведения.


Отзывы о книге «Individual Participant Data Meta-Analysis»

Обсуждение, отзывы о книге «Individual Participant Data Meta-Analysis» и просто собственные мнения читателей. Оставьте ваши комментарии, напишите, что Вы думаете о произведении, его смысле или главных героях. Укажите что конкретно понравилось, а что нет, и почему Вы так считаете.

x