Pathology of Genetically Engineered and Other Mutant Mice

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PATHOLOGY OF GENETICALLY ENGINEERED AND OTHER MUTANT MICE
An updated and comprehensive reference to pathology in every organ system in genetically modified mice Pathology of Genetically Engineered and Other Mutant Mice
Pathology of Genetically Engineered and Other Mutant Mice

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Pathology of Genetically Engineered and Other Mutant Mice

Edited by

John P. Sundberg, DVM, PhD, Dipl. ACVP

The Jackson Laboratory

Bar Harbor, ME, USA

Department of Dermatology

Vanderbilt University Medical Center

Nashville, TN, USA

Peter Vogel, DVM, PhD, Dipl. ACVP

Pathology Department

St. Jude Children's Research Hospital

Memphis, TN, USA

Jerrold M. Ward, DVM, PhD, Dipl. ACVP, Fellow IATP

Global VetPathology

Montgomery Village, MD, USA

This edition first published 2022 2022 John Wiley Sons Inc All rights - фото 1

This edition first published 2022

© 2022 John Wiley & Sons, Inc.

All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, except as permitted by law. Advice on how to obtain permission to reuse material from this title is available at http://www.wiley.com/go/permissions.

The right of John P. Sundberg, Peter Vogel, and Jerrold M. Ward to be identified as the authors of the editorial material in this work has been asserted in accordance with law.

Registered Office John Wiley & Sons, Inc., 111 River Street, Hoboken, NJ 07030, USA

Editorial Office 111 River Street, Hoboken, NJ 07030, USA

For details of our global editorial offices, customer services, and more information about Wiley products visit us at www.wiley.com.

Wiley also publishes its books in a variety of electronic formats and by print‐on‐demand. Some content that appears in standard print versions of this book may not be available in other formats.

Limit of Liability/Disclaimer of Warranty The contents of this work are intended to further general scientific research, understanding, and discussion only and are not intended and should not be relied upon as recommending or promoting scientific method, diagnosis, or treatment by physicians for any particular patient. In view of ongoing research, equipment modifications, changes in governmental regulations, and the constant flow of information relating to the use of medicines, equipment, and devices, the reader is urged to review and evaluate the information provided in the package insert or instructions for each medicine, equipment, or device for, among other things, any changes in the instructions or indication of usage and for added warnings and precautions. While the publisher and authors have used their best efforts in preparing this work, they make no representations or warranties with respect to the accuracy or completeness of the contents of this work and specifically disclaim all warranties, including without limitation any implied warranties of merchantability or fitness for a particular purpose. No warranty may be created or extended by sales representatives, written sales materials or promotional statements for this work. The fact that an organization, website, or product is referred to in this work as a citation and/or potential source of further information does not mean that the publisher and authors endorse the information or services the organization, website, or product may provide or recommendations it may make. This work is sold with the understanding that the publisher is not engaged in rendering professional services. The advice and strategies contained herein may not be suitable for your situation. You should consult with a specialist where appropriate. Further, readers should be aware that websites listed in this work may have changed or disappeared between when this work was written and when it is read. Neither the publisher nor authors shall be liable for any loss of profit or any other commercial damages, including but not limited to special, incidental, consequential, or other damages.

Library of Congress Cataloging‐in‐Publication Data

Names: Sundberg, John P., editor. |Vogel, Peter, editor. | Ward, Jerrold Michael., editor.

Title: Pathology of genetically engineered and other mutant mice / edited by John P. Sundberg, Peter Vogel, Jerrold M. Ward.

Other titles: Pathology of genetically engineered mice

Description: Second edition. | Hoboken, NJ : Wiley‐Blackwell, 2022. | Preceded by Pathology of genetically engineered mice / Jerrold M. Ward … [et al.]. 1st ed. 2000. | Includes bibliographical references and index.

Identifiers: LCCN 2021009923 (print) | LCCN 2021009924 (ebook) | ISBN 9781119624578 (cloth) | ISBN 9781119624585 (adobe pdf) | ISBN 9781119624592 (epub)

Subjects: MESH: Mice, Transgenic–abnormalities | Disease Models, Animal

Classification: LCC RB125 (print) | LCC RB125 (ebook) | NLM QY 60.R6 | DDC 636.089/607–dc23

LC record available at https://lccn.loc.gov/2021009923LC ebook record available at https://lccn.loc.gov/2021009924

Cover Design: Wiley

Cover Images: © John P. Sundberg, Peter Vogel, Jerrold M. Ward

List of Contributors

Cheryl Ackert‐Bicknell, PhDDepartment of Orthopedics School of Medicine University of Colorado Aurora, CO, USA

Hibret A. Adissu, DVM, MSc, PhD, DVSc, Dipl. ACVPPathology, Early Development Covance, Inc. Chantilly, VA, USA

Dale A. Begley, PhDThe Jackson Laboratory Bar Harbor, ME, USA

Akash Behera, BSCollege of Natural Sciences University of Massachusetts Amherst Amherst, MA, USA

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