Pathology of Genetically Engineered and Other Mutant Mice

18 Chapter 18Figure 18.1 Normal kidney. Longitudinal section shows cortex, medulla, papil...Figure 18.2 Normal kidney. Bowman capsule with flat or cuboidal epithelium i...Figure 18.3 Normal glomerulus. Vimentin (VIM) IHC. Note foot processes of po...Figure 18.4 Normal glomerulus. Kinase insert domain protein receptor (KDR, f...Figure 18.5 Focal segmental glomerular sclerosis (FSGS), SAND model, 36 expe...Figure 18.6 Focal segmental glomerular sclerosis (FSGS), SAND model, 36 week...Figure 18.7 Proliferative glomerulonephritis. Increased cellularity of glome...Figure 18.8 Membranous glomerulonephritis. Thickened glomerular capillary ba...Figure 18.9 Membranoproliferative glomerulonephritis. Increased cellularity ...Figure 18.10 Sclerotic glomerulus. PAS stain shows positive material in mesa...Figure 18.11 Amyloid.Hyaline material throughout the glomerulus, adhesions ...Figure 18.12 Amyloid. Congo Red stain reveals amyloid. Aged C57BL/6J mouse....Figure 18.13 Collagenopathy. Note abundant eosinophilic material in glomerul...Figure 18.14 Collagenopathy. Note abundant collagen (blue) in glomeruli. Mas...Figure 18.15 Immune‐mediated glomerulonephritis. Human kappa light cha...Figure 18.16 Fibronectin glomerulopathy. Increased focal and diffuse mesangi...Figure 18.17 Tumor lysis syndrome. Blue material is DNA from a necrotic T‐ce...Figure 18.18 Tumor metastases within glomerulus. Metastatic CD3 +(CD3E) lymp...Figure 18.19 Tumor metastases within glomerulus. Histiocytic sarcoma cells w...Figure 18.20 Lupus glomerulonephritis. IgG (green) and C3 (red) fluorescence...Figure 18.21 Polycystic kidney. Note numerous dilated and cystic tubules occ...Figure 18.22 Glycogen storage disease. There is abundant glycogen in tubular...Figure 18.23 Chapparvovirus (MKPV, mouse kidney parvovirus) infection. Many ...Figure 18.24 Streptozocin‐induced clear intranuclear tubule cell inclusions...Figure 18.25 Preneoplastic renal tubule cell atypical hyperplasia. A single ...Figure 18.27 Renal papillary tubular adenoma. There is compression of adjace...Figure 18.28 Solid renal tubular cell adenocarcinoma. Necrosis is seen. Chem...Figure 18.29 Renal clear cell carcinoma. Glycogen‐like clear cytoplasm. Chem...Figure 18.30 Bladder fixation and trimming protocol. Inflate bladder with 50...Figure 18.31 Bladder diffuse and nodular hyperplasia. Note diffuse and nodul...Figure 18.32 Large and small bladder papillomas. The adjacent epithelium is ...Figure 18.33 Bladder transitional cell carcinoma. Invasion of the bladder wa...

19 Chapter 19Figure 19.1 Mouse reproductive tract. (a) Mouse reproductive tract in situ . ...Figure 19.2 Protocol for longitudinal and cross sections of uterine tissue. ...Figure 19.3 Cystic and hemorrhagic ovaries from Esr1 −/− ‐Rosa26 ...Figure 19.4 Hypoplastic uterus from an Esr1 tm3.1Ksk /Esr1 tm3.1Kskmouse. (a) ...Figure 19.5 Mouse high‐grade serous carcinoma arising from the ovarian surfa...Figure 19.6 Mouse high‐grade serous carcinoma arising from the tubal epithel...Figure 19.7 Mouse serous endometrial carcinoma. (a) Early atypical lesions 6...Figure 19.8 Spontaneous granulosa cell tumor in an aged FVB/NJ mouse (a and ...Figure 19.9 Spontaneous ovarian cysts in an aged C57L/J mouse (a and b). Cys...Figure 19.10 Spontaneous luteoma in the ovary of an aged 129S1/SvlmJ mouse (...

20 Chapter 20Figure 20.1 Mouse male reproductive system. Seminal vesicles (SV), preputial...Figure 20.2 Mouse prostate and associated accessory sex glands en bloc. Semi...Figure 20.3 The mouse preputial glands are composed of acini (A) and large, ...Figure 20.4 The Bulbourethral glands (Cowper’s glands) are multilobular glan...Figure 20.5 Ampullary glands are lined by a cuboidal epithelium with charact...Figure 20.6 The Seminal vesicles are composed of tall columnar epithelium (E...Figure 20.7 Benign polyp of the seminal vesicles in the TRAMP (Tg(TRAMP)8247...Figure 20.8 Gross prostate lobes and Seminal vesicles. (a) Ventral view, (b)...Figure 20.9 The four mouse prostate lobes are histologically distinct. (a) C...Figure 20.10 Classification of lesions of the prostate in genetically engine...Figure 20.11 TRAMP (Tg(TRAMP)8247Ng) mouse model with neuroendocrine carcino...Figure 20.12 Prostatic adenocarcinoma from a mouse with conditional prostate...Figure 20.13 Adenocarcinoma from an overexpressing MYC (FVB‐Tg(ARR2/Pbsn‐MYC...Figure 20.14 Neuroendocrine carcinoma metastasis to the liver from TRAMP mod...Figure 20.15 Testis. (a) Normal seminiferous tubules (arrowheads) separated ...Figure 20.16 Testis. Multinucleate germ cells (symplasts). Symplasts (arrows...Figure 20.17 Testis. Straight seminiferous tubules (tubuli recti) are lined ...Figure 20.18 Epididymis. (A) The head of the epididymis has small lumen line...Figure 20.19 Epididymis, Epithelium with focal karyomegaly. An atypical enla...Figure 20.20 Testis. (a) Tubular necrosis. (b) A higher magnification of ins...Figure 20.21 Epididymis, tail. Dilation, sperm stasis, and granuloma. (a) Se...Figure 20.22 (a) Epididymis‐segmental dilation (arrows) with luminal aggrega...Figure 20.23 Epididymis, body. Epithelial vacuolation. This finding was not ...Figure 20.24 Testis. Diffuse tubular atrophy/hypoplasia.(a) Complete germ c...Figure 20.25 Testis. Multifocal tubular atrophy/hypoplasia, multifocal. (a) ...Figure 20.26 Testis. Failure of meiosis. Seminiferous tubules show spermatoc...Figure 20.27 Testis, Defects in spermiogenesis and spermiation. (a) Defect i...Figure 20.28 Testis. Degeneration of elongated spermatids. Large structures ...Figure 20.29 Testis. Tubular degeneration/atrophy with multinucleate germ ce...Figure 20.30 Testis. Germ cell dissociation. (a) Germ cells are dissociated ...Figure 20.31 Mouse testis. Teratoma. (a) Differentiation into epithelial, me...

21 Chapter 21Figure 21.1 Dorsal view of brain.Figure 21.2 Ventral view of brain.Figure 21.3 Coronal (cross) section of brain at the level of the thalamus, w...Figure 21.4 Coronal (cross) section of brain at the level of the midbrain, w...Figure 21.5 Artifactual vacuolation of the white matter of the cerebellum fo...Figure 21.6 Artifactual spaces surrounding the vessels following intravascul...Figure 21.7 Parasagittal (lateral of midline) section of brain. Nissl stain....Figure 21.8 Sagittal section of spine, showing the orientation of the spinal...Figure 21.9 Cross section of the spinal cord in situ with nerves and ganglia...Figure 21.10 Cross section of spinal cord in situ in an aged C57BL/6 mouse w...Figure 21.11 Dark neuron artifact in mouse cerebrum.HE.Figure 21.12 Touch artifact at the surface of the mouse cerebrum due to hand...Figure 21.13 Hypereosinophilic, dead neurons in the cerebrum of an FVB mouse...Figure 21.14 Artifactual clear space (halos) surrounding oligodendrocytes in...Figure 21.15 Artifactual clear space (perivascular clefts) surrounding blood...Figure 21.16 Artifactual clear space and separation of the dentate gyrus of...Figure 21.17 Histologic appearance of the normal corpus callosum in a BALB/c...Figure 21.19 Dermoid cyst in the spinal cord of a B6SJL‐Tg(SOD1*G93A)1Gur/J...Figure 21.20 Encephalitis and abscesses in an immunosuppressed Myd88tm1Aki m...Figure 21.21 Eosinophilic intracytoplasmic neuronal inclusions in the thalam...Figure 21.22 Neuroaxonal dystrophy in the medulla oblongata (gracilis nucleu...Figure 21.23 Neoplastic lymphocytes (lymphoma) expanding the meninges of an...Figure 21.24 Neuronal loss with astrogliosis in a mouse with a conditional n...Figure 21.25 Ubiquitin positive plaques in the cortex of a seven‐month‐old f...Figure 21.26 Amyloid beta positive plaques in the cortex of a seven‐month‐ol...Figure 21.27 Amyloid plaques and microgliosis in the cortex of a six‐month‐o...Figure 21.28 Tauopathy and neurofibrillary tangles in the medulla oblongata...Figure 21.29 Constitutive tyrosine hydroxylase expression in the substantia...Figure 21.30 Neurodegenerative changes with Lewy body‐like inclusions in the...Figure 21.31 Inflammation and demyelination in the spinal cord of a mouse mo...Figure 21.32 Neurons with accumulated intracytoplasmic vacuolated material i...Figure 21.33 Medulloblastoma at the level of the medulla and cerebellum. Ins...