Pathology of Genetically Engineered and Other Mutant Mice

6 Chapter 6 Figure 6.1 Nasal epithelium. Motile cilia are present on respiratory epithel... Figure 6.2 Brain hydrocephalus. Ependymal ciliary dysfunction often results ... Figure 6.3 Epididymis. Flagellar defects or dysfunction are common causes of... Figure 6.4 Polycystic kidney disease. Dilatation of renal tubules in an enla... Figure 6.5 Nephronophthisis. Cystic tubules with interstitial inflammation a... Figure 6.6 Eye. Macrophages within the outer segment of photoreceptor are pr... Figure 6.7 Eye. Advanced retinal degeneration there is characterized by a ma...

7 Chapter 7 Figure 7.1 Bone marrow. Bone marrow hypoplasia four days after deletion of C ... Figure 7.2 Thymus. (a, b). Medulla of thymus of a female C57BL/6J mouse (a) ... Figure 7.3 Lymph nodes. C57BL/6J (a–c), B6.Cg‐ Foxn1 nu(d–f), B6.129S7‐ Rag1 tm... Figure 7.4 Amyloid. (a) Amyloid in mesenteric lymph node of 615‐day old C57B... Figure 7.5 Mucosal lymphoid tissues. (a) Peyer's patch in C57BL/6 J mouse. (... Figure 7.6 Spleen. Spleen of C57BL/6J (a), B6.Cg‐ Foxn1 nu(b), B6.129S7‐ Rag1 t... Figure 7.7 Melanin vs. hemosiderin. (a) Spleen of B6.Cg‐ Prkdc scid/SzJ mouse ... Figure 7.8 Tertiary lymphoid structures. Tertiary lymphoid tissue with two f...

8 Chapter 8Figure 8.1 Monocytic leukemia, H&E. Spleen with blasts and immature form...Figure 8.2 Monocytic leukemia, IHC. The cells in Figure 8.1 express the mono...Figure 8.3 Erythroleukemia, H&E. Bone marrow with blasts and differentia...Figure 8.4 Erythroleukemia, IHC. The more differentiated cells in Figure 8.3...Figure 8.5 Mast cell leukemia, H&E. Spleen with small and large cells wi...Figure 8.6 Mast cell leukemia, IHC. The cells in Figure 8.5 express CD117 (C...Figure 8.7 Follicular lymphoma, H&E. Lymph node with an abundance of cen...Figure 8.8 Follicular lymphoma, IHC. The neoplastic cells in Figure 8.7 expr...Figure 8.9 DLBCL, anaplastic variant, H&E. This lymphoma variant has hal...Figure 8.10 DLBCL, anaplastic variant, IHC. The neoplastic cells in Figure 8...Figure 8.11 Diffuse high‐grade blastic B‐cell lymphoma, H&E....Figure 8.12 Diffuse high‐grade blastic B‐cell lymphoma, IHC. The...Figure 8.13 Peripheral T‐cell lymphoma (PTCL), small cell, H&E. A ...Figure 8.14 PTCL, small cell, IHC. The neoplastic cells in Figure 8.13 expre...Figure 8.15 PTCL, small cell, H&E. A splenic lymphoma with a monomorphic...Figure 8.16 PTCL, small cell, IHC. The neoplastic cells in Figure 8.15 expre...Figure 8.17 PTCL, large cell, H&E. A splenic lymphoma with a monomorphic...Figure 8.18 PTCL, large cells, IHC. The neoplastic cells in Figure 8.17 expr...

9 Chapter 9Figure 9.1 Kidney of a CB17.Cg‐Prkdc scid Lyst bg ‐J/Crl mouse. Rena...Figure 9.2 Representative sections of lymphoid organs. The spleen (a), thymu...Figure 9.3 Representative sections of spleen. The spleen of NOD.Cg‐ Prkdc scidFigure 9.4 Representative sections of lymph node. The cortical and medullary...Figure 9.5 Heterotopic implantation (subcutis). A patient‐derived lymphoma i...Figure 9.6 Bone marrow of a NOD.Cg‐Prkdc scid Il2rg tm1Wjl mouse engrafted...Figure 9.7 Skin of a NOD.Cg‐Prkdc scid Il2rg tm1Wjl mouse. Inflammatory ce...Figure 9.8 Diffuse large B cell lymphoma of human origin that occurred at th...Figure 9.9 Bone marrow failure with secondary septicemia after irradiation a...Figure 9.10 Kidney with inclusion body nephropathy caused by mouse kidney pa...Figure 9.11 Macroscopic appearance of the gastrointestinal tract in a NOD.Cg...Figure 9.12 Superficial necrotizing colitis caused by C. difficile. Multifoc...Figure 9.13 Naturally occurring Candida glabrata infection in the brain of a...Figure 9.14 Demodex musculi infestation in a NOD.Cg‐Prkdc scid Il2rg tm1W...Figure 9.15 Natural mammalian orthoreovirus infection in a NOD.Cg‐Prkdc...Figure 9.16 Pneumocystis murina infection in a NOD.Cg‐Prkdc scid Il2rg tm...Figure 9.17 Naturally occurring glomerulonephritis in an athymic nude mouse,...

10 Chapter 10Figure 10.1 Embryonic hair follicle development. The epidermis is relatively...Figure 10.2 Gross differences in hair cycle stage. An agouti C3H/HeJ shaved ...Figure 10.3 Major stages of the hair cycle in adult C57BL/6NJ mice. While su...Figure 10.4 Evaluation of plucked hair. Hair can be manually plucked from a ...Figure 10.5 Vibrissae and tail hair follicles. Vibrissae follicles (A–C) are...Figure 10.6 Specialized hairs and nail. Cilia (c) in the eyelid have their o...Figure 10.7 Normal late anagen truncal hair follicle.Low magnification (A) ...Figure 10.8 Commonly used markers for skin.Smooth muscle actin (SMA) is a g...Figure 10.9 Interdigitation of the cuticle layers. The cuticle of the inner ...Figure 10.10 Selecting ages for phenotyping. Set ages based on normal develo...Figure 10.11 Disease progression of alopecia areata. Full thickness skin gra...Figure 10.12 Disease progression of dermatitis in Sharpin cpdm mice. Mutan...Figure 10.13 Proliferation rates of skin. Brown labeled nuclei in a Sharpin c...Figure 10.14 Horizontal sections. Most skin sections are evaluated as vertic...Figure 10.15 Zymbal's gland. The Zymbal's gland is located at the base o...Figure 10.16 Primary cicatricial (scarring) alopecia. A number of mutations ...Figure 10.17 B6 alopecia and dermatitis. C57BL/6 substrains are prone to dev...Figure 10.18 Hairless allelic mutations. B6.Cg mice homozygous for the hairl...Figure 10.19 Excessive hair growth. The angora (a, C57BL/6J‐ Fgf5 gotop, wild...Figure 10.20 Follicular dystrophy genocopies. Severe twisting of weak, defor...Figure 10.21 Hair structural defects. Mice carrying a mutation in the desmop...Figure 10.22 Alopecia areata. Bald patches of skin are evident on the dorsal...Figure 10.23 Spontaneous trichepithelioma in an HRS/J male. Multiple cysts f...Figure 10.24 Spontaneous papillomas in mice. Spontaneous papillomas are foun...Figure 10.25 Spontaneous squamous cell carcinoma. An aggressive squamous cel...Figure 10.26 Spontaneous nonmelanoma skin cancer. Some mutant strains, such ...Figure 10.27 UV light‐induced skin tumors. Outbred Crl:SKH1‐ Hr hrhairl...Figure 10.28 Mouse papillomavirus (MmuPV1) infection. MmuPV1 causes benign p...Figure 10.29 Spontaneous pigmented epithelioid melanocytoma. Melanomas very ...Figure 10.30 Pemphigus vulgaris. Blister formation within the epidermis and ...Figure 10.31 Junctional epidermolysis bullosa. The Lamc2 jeb/jebhypomorphic ...Figure 10.32 Nail dystrophy with rotation of P3 in NON/ShiLtJ mice. A common...Figure 10.33 Subungual intraosseous cysts in old mice. This is a rare sponta...