Clinical Dilemmas in Diabetes

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Clinical Dilemmas in Diabetes Now in its second edition,
contains extensively reviewed and revised information throughout. New and updated chapters examine prediction, diagnosis, and management of early Type 1 diabetes, ophthalmic complications, screening asymptomatic patients for cardiovascular disease, new agents for treatment of dyslipidemia, closed loop systems in Type 1 diabetes, upper gastrointestinal manifestations, managing hyperglycemia in critically ill patients, and more. Edited by Dr. Vella at the Mayo Clinic, this highly practical resource:
Encourages evidence-based clinical decision-making, rather than algorithm-based approaches Provides clear guidance on common problematic areas, especially in cases where conflicts in treatment for the disease and the complications occur Emphasizes the importance of translating the results of clinical trials to individual care and management of diabetes Contains effective learning and revision tools, including Learning Points, chapter introductions and summaries, tables and figures, color diagrams and charts, and full references Part of the popular
series,
is a must-have guide for anyone involved in the treatment of patients with diabetes, particularly endocrinologists, diabetes specialists and consultants, cardiologists, residents, fellows, specialist nurses, and general practitioners with an interest in diabetes.

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10 Index

11 End User License Agreement

List of Tables

1 Chapter 1 TABLE 1.1 The sensitivity of various indices of glycemia used to diagnose ty... TABLE 1.2 The sensitivity of various indices of glycemia used to diagnose pr...

2 Chapter 2 TABLE 2.1 Prevention in T1D TABLE 2.2 Current TrialNet studies. (Source: www.trialnet.net) TABLE 2.3 Immunotherapy trials that are awaiting, or currently recruiting, p...

3 Chapter 4 TABLE 4.1 Types of diabetes. TABLE 4.2 Overview of secondary diabetes due to pancreatic disease and hormo... TABLE 4.3 Clinical features of T1DM, T2DM and CFRD. Adapted from [49].

4 Chapter 6TABLE 6.1 Options for GDM screening and diagnosis.TABLE 6.2 Guidelines for gestational weight gain based on prepregnancy BMI.

5 Chapter 8TABLE 8.1 International consensus on use of CGM.TABLE 8.2 Measures used to quantify glycemic variation (modified from [64]).

6 Chapter 9TABLE 9.1 Continuous glucose monitoring (CGM) impact in diabetes (randomized...TABLE 9.2 Pivotal studies of closed loop system.TABLE 9.3 Brief synopsis of current and future technologies in closed loop.

7 Chapter 11TABLE 11.1 Direct and indirect effects of metformin therapy.TABLE 11.2 Molecular targets of PPARγ and PPAR α action.

8 Chapter 12TABLE 12.1 GLP‐1 RAs: effects on glucose and weight in head‐to‐head trials.

9 Chapter 14TABLE 14.1 Patient characteristics that might affect prescribing.

10 Chapter 15TABLE 15.1

11 Chapter 19TABLE 19.1 Class I indications for myocardial revascularization in stable i...

12 Chapter 20TABLE 20.1 Trial design, patient characteristics.TABLE 20.2 APACHE scores and mortality data.TABLE 20.3 Hypoglycemia data.

13 Chapter 21TABLE 21.1 Ocular complications of diabetes and treatment options.TABLE 21.2 Initial screening recommendations for DR in patients with diabet...TABLE 21.3 International classification of diabetic retinopathy and diabeti...

14 Chapter 22TABLE 22.1 Treatment strategies for patients with gastroparesis (reproduced...

List of Illustrations

1 Chapter 1 FIG 1.1 Histogram with superimposed composite and component curves to descri... FIG 1.2 Postprandial and fasting glucose concentrations are determined by in...

2 Chapter 2 FIG 2.1 Pathogenesis and natural history of Type 1 diabetes. Atkinson MA and... FIG 2.2 Strategies to preserve β‐cell mass in T1D. Modified from Reimann M, ... FIG 2.3 T1D clinical research over the past 10 year. Atkinson MA, Roep BO, P...

3 Chapter 4 FIG 4.1 Proposed algorithm for screening and treatment of haemochromatosis i...

4 Chapter 6FIGURE 6.1 Key factors contributing to excessive fetal growth.

5 Chapter 7FIG 7.1 Typical patient glucose logbook with self‐reported data.FIG 7.2 Modal Day presentation of downloaded meter with SMBG data.FIG 7.3 Varying outputs from commercially available CGM devices.FIG 7.4 CGM device output as a Modal Day.FIG 7.5 Universal CGM output as ambulatory glucose profile (AGP). A. Subject...

6 Chapter 8FIG 8.1A Glycemic variation with frequent insulin supplements. 40‐year‐old w...FIG 8.1B Glycemic variation due to within day variation (WDV) from steroids....

7 Chapter 10FIG 10.1 Schematic representation of the relationship between caloric densit...

8 Chapter 11FIG 11.1 Hypothesized mechanism of action of metformin on hepatic glucose pr...FIG 11.2 Effects of metformin on fatty acid metabolism.FIG 11.3 Effects of thiazolidinediones.

9 Chapter 14FIG 14.1 Therapeutic classes clustered by therapeutic effect versus the leve...

10 Chapter 17FIG 17.1 Role of PCSK9 in hepatic uptake of LDL particles. Low density lipop...FIG 17.2 Metabolism of triglyceride‐rich lipoproteins (TGRL). The two princi...

11 Chapter 18FIG 18.1 Bariatric surgeries. (A) Laparoscopic adjustable gastric banding (G...

12 Chapter 19FIG 19.1 Algorithm to guide diagnosis and management.

13 Chapter 20FIG 20.1 Energy supply expressed as a percentage of estimated basal energy e...FIG 20.2 Energy supply versus insulin infusion rate in five studies.

14 Chapter 21FIG 21.1 Diabetic retinopathy and diabetic macular edema. A. Fundus photogra...

15 Chapter 22FIG 22.1 Assessment of gastric emptying by scintigraphy. Normally liquids ar...

Guide

1 Cover Page

2 Title Page

3 Copyright Page

4 List of Contributors

5 Preface

6 Table of Contents

7 Begin Reading

8 Index

9 Wiley End User License Agreement

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