Ли Ноу: Эгоистичная митохондрия. Как сохранить здоровье и отодвинуть старость

Hagen T. M., et al. Mitochondrial decay in the aging rat heart: evidence for improvement by dietary supplementation with acetyl-L-carnitine and/or lipoic acid. Ann NY Acad Sci. 2002 Apr; 959:491–507. doi:10.1111/j.1749–6632.2002.tb02119.

Hans C. P., Chaudhary D. P., Bansal D. D. Magnesium deficiency increases oxidative stress in rats. Ind J Exp Biol. 2002 Nov; 40(11):1275–9.

Hans C. P., Chaudhary D. P., Bansal D. D. Effect of magnesium supplementation on oxidative stress in alloxanic diabetic rats. Magnes Res. 2003 Mar; l6(1):13–9.

Klevay L. M., Milne D. B. Low dietary magnesium increases supraventricular ectopy. Am J Clin Nutr. 2002 Mar; 75(3):550–4.

Kramer J. H., et al. Dietary magnesium intake influences circulating proinflammatory neuropeptide levels and loss of myocardial tolerance to postischemic stress. Exp Biol Med (Maywood). 2003 Jun; 228(6):665–73. Kubota T., et al. Mitochondria are intracellular magnesium stores: investigation by simultaneous fluorescent imagings in PC12 cells. Biochim Biophys Acta. 2005 May 15; 1744(1):19–28. Epub 2004 Nov 11. doi:10.1016/j. bbamcr.2004.10.013.

Laires M. J., Monteiro C. P., Bicho M. Role of cellular magnesium in health and human disease. Front Biosci. 2004 Jan; 9:262–76.

Lukaski H. C., Nielsen F. H. Dietary magnesium depletion affects metabolic responses during submaximal exercise in postmenopausal women. J Nutr. 2002 May; 132(5):930–5.

Maier J. A., et al. Low magnesium promotes endothelial cell dysfunction: implications for atherosclerosis, inflammation and thrombosis. Biochim Biophys Acta. 2004 May 24; 1689(l):13–21. doi:10.1016/j.bba-dis.2004.01.002.

Moreira P. I., et al. Lipoic acid and N-acetyl cysteine decrease mitochondrial-related oxidative stress in Alzheimer disease patient fibroblasts. J Alzheimers Dis. 2007 Sep; 12(2):195–206.

Nair R. R., Nair P. Alteration of myocardial mechanics in marginal magnesium deficiency. Magnes Res. 2002 Dec; 15(3–4):287–306.

Nakayama S., et al. Mechanisms for monovalent cation-dependent depletion of intracellular Mg2+:Na(+)-independent Mg2+ pathways in guinea-pig smooth muscle. J Physiol. 2003 Sep 15;551(Pt 3):843–53. doi:10.1113/ jphysiol.2003.047795.

Paolisso G., Barbagallo M. Hypertension, diabetes mellitus, and insulin resistance: the role of intracellular magnesium. Am J Hyperten. 1997 Mar 1;10(3):346–55. doi:10.1016/S0895 -7061(96)00342-1.

Resnick L. M., et al. Cellular-free magnesium depletion in brain and muscle of normal and preeclamptic pregnancy: a nuclear magnetic resonance spectroscopic study. Hypertension. 2004 Sep:44(3):322–6. doi:10.1161/01. HYP.0000137592.76535.8c.

Rubenowitz E., Axelsson G., Rylander R. Magnesium in drinking water and death from myocardial infarction. Am J Epidemiol. l996; 143:456–62.

Sinatra S. T. The Sinatra solution: metabolic cardiology. Laguna Beach, CA: Basic Health Publications, Inc; 2011.

Takaya J., Higashino H., Kobayashi Y. Intracellular magnesium and insulin resistance. Magnes Res. 2004 Jun; 17(2):126–36.

Touyz R. M. Role of magnesium in the pathogenesis of hypertension. Mol Aspects Med. 2003 Feb — Jun; 24(1–3):107–36. doi:10.1016/S0098-2997(02)00094-8.

Touyz R. M., et al. Effects of low dietary magnesium intake on development of hypertension in stroke-prone spontaneously hypertensive rats: role of reactive oxygen species. J Hypertens. 2002 Nov; 20(11):2221–32.

Biewenga G. P., Haenen G. R., Bast A. The pharmacology of the antioxidant lipoic acid. Gen Pharmacol. 1997 Sep; 29(3):315–31. doi:10.1016/ S0306-3623(96)00474-0.

Femiano F., Scully C. Burning mouth syndrome (BMS): double blind controlled study of alphalipoic acid (thioctic acid) therapy. J Oral Pathol Med. 2002 May; 31(5):267–9. doi:10.1034/j.1600–0714.2002.310503.

Hagen T. M., et al. (R)-alpha-lipoic acid-supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate. FASEB J. 1999 Feb; 13(2):411–8.

Hagen T. M., et al. Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress. Proc Natl Acad Sci USA. 2002 Feb 19; 99(4):1870–5. doi:10.1073/ pnas.261708898.

Hagen T. M., et al. Mitochondrial decay in the aging rat heart: evidence for improvement by dietary supplementation with acetyl-L-carnitine and/or lipoic acid. Ann NY Acad Sci. 2002 Apr; 959:491–507. doi:10.1111/j.1749–6632.2002.tb02119.

Hager K., et al. Alpha-lipoic acid as a new treatment option for Alzheimer type dementia. Arch Gerontol Geriatr. 2001 Jun; 32(3):275–82.

Jia L., et al. Acrolein, a toxicant in cigarette smoke, causes oxidative damage and mitochondrial dysfunction in RPE cells: protection by (R)-alpha-lipoic acid. Invest Ophthalmol Vis Sci. 2007 Jan; 48(1):339–48. doi:10.1167/iovs.06-0248.

Jiang T., et al. Lipoic acid restores age-associated impairment of brain energy metabolism through the modulation of Akt/JNK signaling and PGC1α transcriptional pathway. Aging Cell. 2013 Dec; 12(6):1021–31. doi:10.1111/acel.12127. doi:10.1111/acel.12127.

Kim D. C., et al. Lipoic acid prevents the changes of intracellular lipid partitioning by free fatty acid. Gut Liver. 2013 Mar; 7(2):221–7. doi:10.5009/ gnl.2013.7.2.221.

Li C. J., et al. Attenuation of myocardial apoptosis by alpha-lipoic acid through suppression of mitochondrial oxidative stress to reduce diabetic cardiomyopathy. Chin Med J (Engl). 2009 Nov 5; 122(21):2580–6.

Liu J., Killilea D. W., Ames B. N. Age-associated mitochondrial oxidative decay: improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-L-carnitine and/or R-alpha-lipoic acid. Proc Natl Acad Sci U S A. 2002 Feb 19; 99(4):1876–81. doi:10.1073/pnas.261709098.

Liu J, et al. Delaying brain mitochondrial decay and aging with mitochondrial antioxidants and metabolites. Ann NY Acad Sci. 2002 Apr;959:133– 66. doi:10.1111/j.1749–6632.2002.tb02090.x.

Liu J., et al. Memory loss in old rats is associated with brain mitochondrial decay and RNA/ DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha- lipoic acid. Proc Natl Acad Sci U S A. 2002 Feb 19; 99(4):2356–61. doi:10.1073/pnas.261709299.

Meydani M., et al. The effect of long-term dietary supplementation with antioxidants. Ann NY Acad Sci. 1998 Nov 20; 854:352–60. doi:10.1111/j.1749–6632.1998.tb09915.

Nyengaard J. R., et al. Interactions between hyperglycemia and hypoxia: implications for diabetic retinopathy. Diabetes. 2004 Nov; 53(11):2931–8. doi:10.2337/diabetes.53.11.2931.

Scott B. C., et al. Lipoic and dihydrolipoic acids as antioxidants. A critical evaluation. Free Radic Res. 1994 Feb; 20(2):119–33. doi:10.3109/10715769409147509.

Tappel A., Fletcher B., Deamer D. Effect of antioxidants and nutrients on lipid peroxidation fluorescent products and aging parameters in the mouse. J Gerontol. 1973 Oct; 28(4):415–24. doi:10.1093/geronj/28.4.415. Thornalley P. J. Glycation in diabetic neuropathy: characteristics, consequences, causes, and therapeutic options. Int Rev Neurobiol. 2002; 50:37–7. doi:10.1016/S0074-7742(02)50072-6.

Williamson J. R., et al. Hyperglycemic pseudohypoxia and diabetic complications. Diabetes. 1993 Jun; 42(6):801–13. doi:10.2337/diab.42.6.801. Ziegler D., et al. Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: a meta-analysis. Diabet Med. 2004 Feb; 21(2):114–21. doi:10.1111/j.1464–5491.2004.01109.