Susannah Cahalan - Brain on Fire - My Month of Madness

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Brain on Fire: My Month of Madness: краткое содержание, описание и аннотация

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One day in 2009, twenty-four-year-old Susannah Cahalan woke up alone in a strange hospital room, strapped to her bed, under guard, and unable to move or speak. A wristband marked her as a “flight risk,” and her medical records—chronicling a monthlong hospital stay of which she had no memory at all—showed hallucinations, violence, and dangerous instability. Only weeks earlier, Susannah had been on the threshold of a new, adult life: a healthy, ambitious college grad a few months into her first serious relationship and a promising career as a cub reporter at a major New York newspaper. Who was the stranger who had taken over her body? What was happening to her mind?
In this swift and breathtaking narrative, Susannah tells the astonishing true story of her inexplicable descent into madness and the brilliant, lifesaving diagnosis that nearly didn’t happen. A team of doctors would spend a month—and more than a million dollars—trying desperately to pin down a medical explanation for what had gone wrong. Meanwhile, as the days passed and her family, boyfriend, and friends helplessly stood watch by her bed, she began to move inexorably through psychosis into catatonia and, ultimately, toward death. Yet even as this period nearly tore her family apart, it offered an extraordinary testament to their faith in Susannah and their refusal to let her go.
Then, at the last minute, celebrated neurologist Souhel Najjar joined her team and, with the help of a lucky, ingenious test, saved her life. He recognized the symptoms of a newly discovered autoimmune disorder in which the body attacks the brain, a disease now thought to be tied to both schizophrenia and autism, and perhaps the root of “demonic possessions” throughout history.
Far more than simply a riveting read and a crackling medical mystery,
is the powerful account of one woman’s struggle to recapture her identity and to rediscover herself among the fragments left behind. Using all her considerable journalistic skills, and building from hospital records and surveillance video, interviews with family and friends, and excerpts from the deeply moving journal her father kept during her illness, Susannah pieces together the story of her “lost month” to write an unforgettable memoir about memory and identity, faith and love. It is an important, profoundly compelling tale of survival and perseverance that is destined to become a classic.

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15 “postictal fury”: S. J. Logsdail and B. K. Toone, “Post-Ictal Psychoses: A Clinical and Phenomenological Description,” British Journal of Psychiatry 152 (1988): 246–252.

16 A quarter of psychotic people: Michael Trimble, Andy Kanner, and Bettina Schmitz, “Postictal Psychosis,” Epilepsy and Behavior 19 (2010): 159–161.

CHAPTER 17: MULTIPLE PERSONALITY DISORDER

17 I was within the age range for psychotic breaks: The New York Times Health Guide, “Schizophrenia,” Health.nytimes.com, http://health.nytimes.com/health/guides/disease/schizophrenia/risk-factors.html(accessed February 20, 2010).

18 dissociative identity disorder (DID): “Dissociative Identity Disorder,” in American Psychiatric Association, Diagnostic and Statistical Manual of Mental Disorders—IV (Text Revision) (Washington, D.C.: American Psychiatric Association, 2 000), 526–529.

19 On of a scale from 1 (most dire cases) to 100: “Bipolar Disorder,” in ibid.

CHAPTER 18: BREAKING NEWS

20 “Like a bolt from the blue”: P. A. Pichot, “A Comparison of Different National Concepts of Schizoaffective Psychosis,” in Schizoaffective Psychoses (Berlin: Springer-Verlag, 1986), 8–16. A. Marneros and M. T. Tsuang, “Schizoaffective Questions and Directions,” in Schizoaffective Psychoses (Berlin: Springer-Verlag, 1986).

21 “uninterrupted period of illness during”: American Psychiatric Association, Diagnostic and Statistical Manual of Mental Disorders—IV (Text Revision) (Washington, D.C.: American Psychiatric Association, 2000), 319–323.

CHAPTER 21: DEATH WITH INTERRUPTIONS

22 In 1933, a bicycle struck seven-year-old Henry Gustav Molaison: Luke Dittrich, “The Brain That Changed Everything,” Esquire.com, October 5, 2010, www.esquire.com/features/henry-molaison-brain-1110(accessed May 8, 2011). “Histopathological Examination of the Brain of Amnesiac Patient H.M.,” Brain Observatory, August 18, 2010, http://thebrainobservatory.ucsd.edu/content/histopathological-examination-brain-amnesic-patient-hm(accessed May 8, 2011). William Beecher Scoville and Brenda Milner, “Loss of Recent Memory after Bilateral Hippocampal Lesions,” Journal of Neurology, Neurosurgery and Psychiatry 20 (1957): 11–21. Benedict Carey, “H.M., an Unforgettable Amnesiac, Dies at 82,” New York Times, December 5, 2008, http://www.nytimes.com/2008/12/05/us/05hm.html?pagewanted=all(accessed May 8, 2011).

23 “Clive was under the constant impression”: Deborah Wearing, Forever Today: A True Story of Lost Memory and Never-Ending Love (London: Corgi, 2006).

24 “I haven’t heard anything”: Oliver Sacks, “The Abyss: Music and Amnesia,” New Yorker, September 24, 2007, http://www.newyorker.com/reporting/2007/09/24/070924fa_fact_sacks(accessed September 13, 2011).

CHAPTER 22: A BEAUTIFUL MESS

25 At the top of the spinal cord and at the underside of the brain: Michael O’Shea, The Brain: A Very Short Introduction (Oxford: Oxford University Press, 2005). Rita Carter, Susan Aldridge, Martyn Page, and Steve Parker, The Human Brain Book (London: DK Adult, 2009). Stephen G. Waxman, Clinical Neuroanatomy, Twenty-Sixth Edition (New York: McGraw Hill, 2010).

26 “The brain is a monstrous, beautiful mess”: William F. Allman, Apprentices of Wonder: Inside the Neural Network Revolution (New York: Bantam, 1989), 3.

CHAPTER 24: IVIG

27 IVIG is made up of serum antibodies: Falk Nimmerjahn and Jeffrey V. Ravetch, “The Anti-Inflammatory Activity of IgG: The Intravenous IgG Paradox,” Journal of Experimental Medicine 204 (2007): 11–15. Arturo Casadevall, Ekaterina Dadachova, and Liise-Anne Pirofski, “Passive Antibody Therapy for Infectious Diseases,” Nature Reviews Microbiology 2 (2004): 695–703. Noah S. Scheinfeld, “Intravenous Immunoglobulin,” Medscape Reference, http://emedicine.medscape.com/article/210367-overview(accessed May 8, 2011).

28 Antibodies are created by the body’s immune system: John M. Dwyer, The Body at War: The Story of Our Immune System (Sydney, Australia: Allen & Unwin, 1994), 28–52. S. Jane Flint, Lynn W. Enquist, Vincent R. Racaniello, and A. M. Skalka, Principles of Virology: Molecular Biology, Pathogenesis, and Control of Animal Viruses, Third Edition (Washington, D.C.: American Society of Microbiology, 2009), 86–130. Noel R. Rose and Ian R. Mackay, eds., The Autoimmune Diseases, Fourth Edition (St. Louis, Mo.: Elsevier, 2006). Lauren Sompayrac, How the Immune System Works, Third Edition (Oxford: Blackwell, 2008). Massoud Mahmoudi, Immunology Made Ridiculously Simple (Miami: Med Master, 2009). Robert G. Lahita, Women and Autoimmune Disease: The Mysterious Ways Your Body Betrays Itself (New York: Morrow, 2004).

29 ten days versus the innate system’s minutes or hours: Vincent Racaniello, “Innate Immune Defenses,” Virology.ws, http://www.virology.ws/2009/06/03/innate-immune-defenses(accessed March 11, 2010). Vincent Racaniello, “Adaptive Immune Defenses,” Virology.ws, http://www.virology.ws/2009/07/03/adaptive-immune-defenses(accessed March 11, 2010).

30 collateral damage of these internal battles: Lauren Sompayrac, How the Immune System Works, Third Edition (Oxford: Blackwell, 2008). Massoud Mahmoudi, Immunology Made Ridiculously Simple (Miami: Med Master, 2009). Robert G. Lahita, Women and Autoimmune Disease: The Mysterious Ways Your Body Betrays Itself (New York: Morrow, 2004).

31 plasma cells that create antibodies: John M. Dwyer, The Body at War: The Story of Our Immune System (Sydney, Australia: Allen & Unwin, 1994), 28–52. S. Jane Flint, Lynn W. Enquist, Vincent R. Racaniello, and A. M. Skalka, Principles of Virology: Molecular Biology, Pathogenesis, and Control of Animal Viruses, Third Edition (Washington, D.C.: American Society of Microbiology, 2009), 86–130. Noel R. Rose and Ian R. Mackay, eds., The Autoimmune Diseases: Fourth Edition (St. Louis: Elsevier, 2006). Lauren Sompayrac, How the Immune System Works, Third Edition (Oxford: Blackwell, 2008). Massoud Mahmoudi, Immunology Made Ridiculously Simple (Miami: Med Master, 2009). Robert G. Lahita, Women and Autoimmune Disease: The Mysterious Ways Your Body Betrays Itself (New York: Morrow, 2004).

32 WIRED ’N MIRED: Brendan T. Carroll, Christopher Thomas, Kameshwari Jayanti, John M. Hawkins, and Carrie Burbage, “Treating Persistent Catatonia When Benzodiazepines Fail,” Current Psychiatry 4 (2005): 59.

CHAPTER 26: THE CLOCK

33 Although developed in the mid-1950s: Janus Kremer, “Clock Drawing in Dementia: A Critical Review,” Revista Neurologica Argentina 27 (2002): 223–227.

34 The healthy brain enables vision: Francesco Pavani, Elisabetta Ladavas, and Jon Driver, “Auditory and Multisensory Aspects of Visuospatial Neglect,” Trends in Cognitive Sciences 7 (2008): 407–414. V. S. Ramachandran and Sandra Blakeslee, Phantoms in the Brain: Probing the Mysteries of the Human Mind (New York: Morrow, 1998), 115–125. V. S. Ramachandran, The Tell-Tale Brain: A Neuroscientist’s Quest for What Makes Us Human (New York: Norton, 2011), 1–21. Michael O’Shea, The Brain: A Very Short Introduction (Oxford: Oxford University Press, 2005). Rita Carter, Susan Aldridge, Martyn Page, and Steve Parker, The Human Brain Book (London: DK Adult, 2009). Stephen G. Waxman, Clinical Neuroanatomy, Twenty-Sixth Edition (New York: McGraw-Hill, 2010).

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