Genome - Matt Ridley

10. Searle, G. R. (1979). Eugenics and politics in Britain in the 1930s. Annals of Political Science 36: 159—69.

336 G E N O M E

11. Kitcher, P. (1996). The lives to come. Simon and Schuster, New York.

12. Quoted in an interview in the Sunday Telegraph, 8 February 1997.

13. Lynn, R. (1996). Dysgenics: genetic deterioration in modern populations. Praeger, Westport, Connecticut.

14. Reported in HMS Beagle: The Biomednet Magazine (www.biomednet.com/

hmsbeagle), issue 20, November 1997.

15. Morton, N. (1998). Hippocratic or hypocritic: birthpangs of an ethical code. Nature Genetics 18: 18; Coghlan, A. (1998). Perfect people's republic.

New Scientist, 24 October 1998, p. 24.

C H R O M O S O M E 2 2

The most intelligent book on determinism is Judith Rich Harris's The nurture assumption (Bloomsbury, 1998). Steven Rose's Lifelines (Penguin, 1998) makes the opposing case. Dorothy Nelkin and Susan Lindee's The DNA mystique (Freeman, 1995) is worth a look.

1. Rich Harris, J. (1998). The nurture assumption. Bloomsbury, London.

2. Ehrenreich, B. and McIntosh, J. (1997). The new creationism. Nation, 9

June 1997.

3. Rose, S., Kamin, L. J. and Lewontin, R. C. (1984). Not in our genes.

Pantheon, London.

4. Brittan, S. (1998). Essays, moral, political and economic. Hume Papers on Public Policy, Vol. 6, no. 4. Edinburgh University Press, Edinburgh.

5. Reznek, L. (1997). Evil or ill? Justifying the insanity defence. Routledge, London.

6. Wilson, E. O. (1998). Consilience. Little, Brown, New York.

7. Darwin's views on free will are quoted in Wright, R. (1994). The moral animal. Pantheon, New York.

8. Silver, B. (1998). The ascent of science. Oxford University Press, Oxford.

9. Ayer, A. J. (1954). Philosophical essays. Macmillan, London.

10. Lyndon Eaves, quoted in Wright, L. (1997). Twins: genes, environment and mystery of identity. Weidenfeld and Nicolson, London.

I N D E X

ADA, 249 Asquith, Herbert, 294

Affymetrix, 267 asthma, 66-75

ageing, 196—205 Austad, Steven, 201—2

AIDS, 124-5, 265, 267—9 Avery, Oswald, 14-15

Alkaptonuria, 39, 52, 71 Avery, Roy, 14

Allison, Anthony, 141 Ayer, A. J., 313

Altman, Sidney, 18

Alzheimer's disease: baboon, 154-60

A P O - E 4 association with, 261-8 Bailey, Michael, 118

inheritance of, 54, 59, 273, 309 Bakewell, Robert, 272

American Lung Association, 68, 73 Baldwin, James Mark, 220-22, 230

Ames, Bruce, 233-4 Balfour, Arthur, 293

Amnion's horn, 227-8 Bateson, William, 39, 4 5 - 6 , 174

Amos, William, 111, 112 BCG, 69

Anderson, French, 248-9 Beadle, George, 47

Anderson, Gerry, 293 Beckwith-Wiedemann syndrome, 210

Angelman, Harry, 207-8 Bede, Venerable, 35

Angelman syndrome, 212-4 bell curve, The (R. J. Herrnstein, C.

apoptosis, 238-42 Murray), 86

Apple, 181 Belloc, Hilaire, 293

Applied Biosystems, 245 Bell Telephone Company, 155

Ardipithecus skeleton, 30 Berg, Paul, 244, 261

Aristode, 13, 16, 174, 184 Bickerton, Derek, 94-5

Ashkenazi Jews, 191-2 Binet, Alfred, 78, 88

Ashworth, Dawn, 132-3 Biogen, 245

338 G E N O M E

Blackburn, Elizabeth, 197 Cech, Thomas, 18

Blaese, Michael, 248—9 Cecil, Lord Robert, 295

Blanchard, Ray, 119 Celera, 246

Blanchflower, Danny, 266 cerebellar ataxia, 59

blood groups, 156—47 Cetus, 245

Blunt, Wilfred Scawen, 294 Chagas' disease, 157

BMP4, 179 Chaplin, Charlie, 136

Boas, Franz, 92 Chesterton, G. K., 293

Boer War (1899-1902), 288 chimpanzee, 24, 27-37, 127

Borna disease, 143 Chomsky, Noam, 9 2 - 3 , 103

Bouchard, Thomas, 82 chronic fatigue syndrome see ME

Bowman Gray Medical School, North Churchill, Winston, 294

Carolina, 170 Cline, Martin, 247

Brave new world (Aldous Huxley), 303 Clinique Medicale (Armand Trousseau), breast cancer see cancer 67

Brittan, Sam, 308 cloning, 212-3, 255-7

Broca's aphasia, 96, 101 Cold Spring Harbour Laboratory, 224, Brock report (1934), 296-7 238, 289

Brock, Sir Laurence, 296 Collins, John, 308

BSE (bovine spongiform encephalopathy), Colossus (computer), 15

59, 281—5 Columbia University, 46

Buck v Bell (1927), 290 'comma-free code', 50

Buck, Carrie, 290 Committee for the Prevention of Jewish Buck, Doris, 290 Genetic Disease, 191, 299

Buck, Emma, 290 Concepcion, Maria, 57

Buck, Vivian, 290 Consilience (Edward Wilson), 310

Buckland, Richard, 132-3 Cookson, William, 72-3

Burt, Cyril, 88 Coppens, Yves, 31

Butler, Samuel, 17 Correns, Carl, 44

Cortisol, 149-56

Caldicott, Dame Fiona, 265 Cosmides, Leda, 102-3

California Institute of Technology, 312 CREB, 224-6, 229, 302

California Supreme Court, 136 Creutzfeldt, Hans, 274

Calment, Jeanne, 203 Creutzfeldt-Jakob disease (CJD), 274—6, Calvin, John, 54, 56 278-80, 284-5

Cambrian explosion, 26, 180-1 Crick, Francis, 13, 14, 4 9 - 5 1 , 61, 138, cancer: 276, 280

breast, 190—1, 236 Culver, Kenneth, 250

D C C suppresses, 244 cyclic AMP, 223-4, 226

TP53 prevents, 233-42 cystic fibrosis, 142 see also Tay-Sachs Capecchi, Mario, 254-5 disease

Carnegie, Andrew, 289

Carter, Rita, 311 Daily Telegraph, 116

Cavalli-Sforza, Luigi Luca, 188-90 Dalton, John, 43

I N D E X 339

Darwin, Charles, 12, 43, 44—6, 93, 103—4, embryological development, 173-84

157—8, 287, 294, 310 embryonic stem cells, 254-7

Darwin, Erasmus, 12, 22 eugenics, 286—300

Darwin, Leonard, 294 Eugenics Education Society, 292-4

Davenport, Charles, 289 European Union, 151, 284

Davies, Michael, 160 Evolution: the four-billion year war (M.

Davis, Ronald, 226 Majerus, W. Amos, G. Hurst), 109

Dawkins, Richard, 26, 50, 104, 128

DAX, 110 Fabian Society, 292-3

de LaPlace, Pierre-Simon, 311 First World War (1914-18), 38, 79

Delbruck, Max, 13 Fisher, Sir Ronald, 42, 46, 291-2

de Miranda, Juan Carreno, 206 Fleming, Alexander, 2 5 8

Department of Health, 296 Flynn, James, 89-90

de Robertas, Eddie, 177 Focke, W. O., 44

Descartes, Rene, 47, 153 Forensic Science Service, 134

Descent of Man, The (Charles Darwin), 158 Forterre, Patrick, 20

de Silva, Ashanthi, 249 Frankenstein, 219, 251, 252

de Vries, Hugo, 44 Franklin, Rosalind, 13, 14

Diamond, Milton, 218 Freeman, Derek, 92

D N A : free will, 75, 301-13

ageing process and, 203 Freud, Sigmund, 92, 119, 218, 305—6

chimpanzee, 28 Friends of the Earth, 252

discovery of, 12-17 fruit fly, 129, 175—84

fingerprinting, 132-6 Furi, Sandra, 144-5

function of, 7 - 9

libraries, 246 Gajdusek, Carleton, 273-4, 277

'recombinant', 244, 248 Galton, Francis, 78, 85, 89, 90, 287-9, scrapie agent, 276 291, 298

'selfish', 124, 127-31, 212, 246Gardner, Howard, 80

structure of, 49-53 Garrod, Archibald, 38-41, 46, 47, 52

Dolgopolsky, Aharon, 187 Garrod, Sir Alfred Baring, 38

Dolly, 208, 213, 255 Gehring, Walter, 177, 178

dopamine, 162-7 Genentech, 245

D o w n syndrome, 287-8, 298 genetically modified organisms, 251-7

du Chaiilu, Paul, 29 genetic engineering, 244-50

Dulbecco, Renato, 240 genetic imprinting, 210-18

Dunnet, George, 201 genetic screening, 261-9

Geron Corporation, 199, 20;

'East Side Story', 31 Gerstmann-Straussler-Scheinker disease, Eaves, Lyndon, 313 278

Ebstein, Richard, 163 Gibbs, Joe, 274