Lloyd Minor - Discovering Precision Health

1 COVER

2 ABOUT THE AUTHORS

3 ACKNOWLEDGMENTS

4 INTRODUCTION: THE POWER OF PRECISION HEALTH THE PRECISION HEALTH PAST—AND PRESENT KEY PRINCIPLES OF PRECISION HEALTH THE TIME IS RIGHT FOR PRECISION HEALTH ABOUT ME THE ORIGINS OF PRECISION HEALTH AT STANFORD ABOUT THE BOOK

5 CHAPTER 1: THE STATE OF U.S. HEALTH AND HEALTH CARE DELIVERY THE HEALTH PARADOX THE U.S. HEALTH CARE CONUNDRUM THE “SOPHISTICATED” TECHNOLOGY IN DOCTORS’ OFFICES THE UNFULFILLED POTENTIAL OF ELECTRONIC HEALTH RECORDS WHAT HANDICAPS THE U.S. HEALTH CARE SYSTEM

6 CHAPTER 2: THERE’S MORE TO “HEALTH” THAN HEALTH CARE PRECISION HEALTH AND POPULATION HEALTH GENES ARE ONE PIECE OF THE HEALTH PUZZLE BEHAVIORS CAN CHANGE—AND DO CHANGE

7 CHAPTER 3: THE INNOVATION AND DISRUPTION POWERING PROGRESS IN HEALTH COMMERCIALIZATION OF SCIENTIFIC AND TECHNOLOGICAL ADVANCES AND THE RELATIONSHIP BETWEEN ACADEMIA AND INDUSTRY HOW DIGITAL HEALTH CAN DRIVE DISRUPTION AND INNOVATION THE ENVIRONMENTS THAT FOSTER INNOVATION HOW THE ARTS HELPED ADVANCE ANTIMICROBIAL THERAPY SHATTERING THE STROKE TREATMENT STOPWATCH DEVELOPING THE THERAPEUTIC OPPORTUNITIES ASSOCIATED WITH STEM CELLS AND REGENERATIVE MEDICINE BRINGING INNOVATION TO IMMUNOLOGY THE APPROACHING REVOLUTION IN SLEEP RESEARCH THE PROGRESS UNDERWAY IN PREDICTING, PREVENTING, AND CURING ALLERGIES THE PROGRESS TOWARD PREDICTING, PREVENTING, AND CURING MENTAL ILLNESS ADVANCING EARLY DETECTION AND TREATMENT OF AUTISM THE BENEFIT OF BIG SCIENCE / BIG PHARMA COOPERATION MAKING BABIES WITH MODERN TECHNOLOGY ADVANCING SCIENCE THROUGH CITIZEN SCIENTISTS DEVELOPING NEW THERAPEUTICS AND REPURPOSING EXISTING DRUGS ACCELERATING INNOVATION IN HEALTH TECHNOLOGY HOW DATA CAN IMPROVE MEDICAL EDUCATION AND HELP MEASURE PHYSICIAN PERFORMANCE DEVELOPING NEW AND BETTER DIAGNOSTIC TOOLS LEVERAGING INTERDISCIPLINARY INNOVATION TO ADVANCE GLOBAL HEALTH BRINGING TRANSPARENCY TO DRUG PRICING DOING THE “IMPOSSIBLE”: USING PLANTS TO PRODUCE “MEAT” MINIMIZING MISTAKES IN MEDICAL RESEARCH INNOVATION GONE WRONG: THOUGHTS ON THERANOS

8 CHAPTER 4: FUNDAMENTAL, DISCOVERY‐FOCUSED RESEARCH: THE FOUNDATION OF BIOMEDICAL BREAKTHROUGHS THE MANY DIFFERENT REASONS FOR RESEARCH A BREAKTHROUGH ENABLED BY BASIC SCIENCE MEDICAL RESEARCH AND UNEXPECTED DISCOVERIES DISCOVERIES IN MOLECULAR BIOLOGY THAT ENABLED GENES TO BE CLONED THE BIRTH OF BIOTECHNOLOGY: CLONING GENES TO PRODUCE PROTEIN DISCOVERY OF A NOVEL MECHANISM RESPONSIBLE FOR REGULATION OF GENE EXPRESSION ELUCIDATION OF THE STRUCTURE OF COMPLEX PROTEINS FOUNDING THE FIELD OF COMPUTATIONAL STRUCTURAL BIOLOGY UNRAVELING HOW NEURONS COMMUNICATE WITH ONE ANOTHER ILLUMINATING OUR UNDERSTANDING OF THE BRAIN PUSHING PHYSICS—AND OTHER DISCIPLINES—TO NEW FRONTIERS EXPANDING OUR UNDERSTANDING OF THE BRAIN’S DEVELOPMENT—AND COUNTERING ITS DECLINE UNDERSTANDING THE MYSTERIES OF AGING REVEALING THE ROOTS OF REGENERATION BREAKTHROUGH TECHNOLOGIES AS A CATALYST FOR BIOMEDICAL DISCOVERIES A TOOL PROVIDING NEW INSIGHTS ABOUT BIOLOGICAL SPECIMENS TRAINING THE NEXT GENERATION OF LEADERS IN BIOMEDICINE

9 CHAPTER 5: PEERING INTO THE FUTURE: LEVERAGING THE POWERS OF PREDICTION TO HELP PREVENT ILLNESS WHAT MEDICINE CAN LEARN FROM AVIATION DON LISTWIN’S CAMPAIGN TO ADVANCE EARLY CANCER DETECTION THE EMERGENCE OF NEW AND IMPROVED DIAGNOSTIC TOOLS FORWARD THROUGH THE PAST BRINGING NEW PRECISION TO RISK MANAGEMENT AND SCREENING FOR BREAST CANCER NEW UNDERSTANDING OF GENETICS AND NEW POTENTIAL TO PREDICT, PREVENT, AND CURE DISEASE THE EMERGING DIGITAL HEALTH REVOLUTION

10 CHAPTER 6: PREVENTION AS A PATHWAY TO HEALTH AND WELLNESS COMBATING DISEASE THROUGH HEALTHY FOOD CONSUMPTION DEPLOYING A DIGITAL TOOL TO IMPROVE THE HUMAN DIET PREVENTING PRETERM BIRTH AS WELL AS PERINATAL AND MATERNAL MORTALITY USING PREVENTION TO BENEFIT CHILDREN A POTENTIALLY NEW CHAPTER IN PREVENTION COMING FROM GENOME SEQUENCING AND DATA SCIENCE SCALING INNOVATION TO HELP MANAGE A CHRONIC CONDITION PREVENTION AT WALMART PREVENTION AT STANFORD

11 CHAPTER 7: CURING DISEASE WITH MORE PRECISE MEDICAL THERAPIES OBSTACLES TO CURES—AND OVERCOMING THEM A MORE PRECISE CANCER TREATMENT: IMMUNOTHERAPY COMBATING GENETIC DISEASES INDIVIDUALIZING CELLULAR APPROACHES TO UNDERSTANDING DISEASES IN INDIVIDUALS MAKING HEADWAY IN THE FIGHT AGAINST HIV‐AIDS PERSISTENT THREATS TO TREATMENT OF INFECTIOUS DISEASES HOW SURGERY IS BECOMING MORE EFFICIENT AND LESS INVASIVE

12 CONCLUSION: ACHIEVING PRECISION HEALTH: THE OPPORTUNITIES—AND CHALLENGES—AHEAD

13 NOTES INTRODUCTION CHAPTER 1 CHAPTER 2 CHAPTER 3 CHAPTER 4 CHAPTER 5 CHAPTER 6 CHAPTER 7 CONCLUSION

14 INDEX

15 END USER LICENSE AGREEMENT

1 Cover

2 Table of Contents

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