Rosette M. Roat-Malone - Bioinorganic Chemistry

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Third Edition

ROSETTE M. ROAT‐MALONE

Washington College

Chestertown, MD, USA

This edition first published 2020

© 2020 John Wiley & Sons, Inc.

Edition History John Wiley & Sons Inc. (1e, 2002) John Wiley & Sons Inc. (2e, 2007)

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Library of Congress Cataloging‐in‐Publication Data

Names: Roat‐Malone, Rosette M., author.

Title: Bioinorganic chemistry : a short course / Rosette M. Roat‐Malone, Washington College, Chestertown, MD.

Description: Third edition. | Hoboken, NJ : Wiley, 2020. | Includes bibliographical references and index.

Identifiers: LCCN 2019030076 (print) | LCCN 2019030077 (ebook) | ISBN 9781119535218 (paperback) | ISBN 9781119535232 (adobe pdf) | ISBN 9781119535263 (epub)

Subjects: LCSH: Bioinorganic chemistry.

Classification: LCC QP531 .R63 2019 (print) | LCC QP531 (ebook) | DDC 572/.51–dc23

LC record available at https://lccn.loc.gov/2019030076LC ebook record available at https://lccn.loc.gov/2019030077

Cover Design: Wiley

Cover Image: Courtesy of Rosette M. Roat‐Malone

For

Rich

Sharon

Suzanne

In 2015, Kara Bren, Richard Eisenberg, and Harry Gray presented their thoughts about the beginnings of bioinorganic chemistry [1]. They credit Pauling and Coryell as the first researchers to realize the importance of the metal and the structure around the metal as the determining factor in hemoglobin's function. The conclusions of Pauling and Coryell, presented 80+ years ago in the Proceedings of the National Academy of Sciences , used a Guoy balance to determine hemoglobin's magnetic behavior. In two 1936 publications, they confirmed that the oxygenated and carbonmonoxygenated forms of hemoglobin were diamagnetic and discovered that the deoxygenated form was magnetic with four unpaired electrons per iron ion [2]. Quoting Bren, Eisenberg, and Gray: “the development of structure/function relationships has been a central theme of modern bioinorganic chemistry, with much attention paid to metal ion electronic structure.” Structure determines function in bioinorganic chemistry and happily we have many modern methods to determine these relationships for the one‐third of proteins that are metalloproteins.

When I first taught a bioionorganic course in the early 1990s, I used the 1984 book written by Robert Hay [3]. I thought those 200 pages told the whole story. Soon I moved on to the 1994 publication (411 pages) by Stephen Lippard and Jeremy Berg [4]. Now, if I were still teaching, I would be faced with 739 pages in the 2007 publication put together by Ivano Bertini, Harry Gray, Ed Stiefel, and Joan Valentine as editors with the help of 60+ contributors [5]. Our bioinorganic field has grown fantastically in the past 30 years, with ongoing discoveries, new and improved methods, and new bioinorganic subdisciplines – nanobioinorganic chemistry for one.