Tamilvanan Shunmugaperumal - Oil-in-Water Nanosized Emulsions for Drug Delivery and Targeting

10 Chapter 8-1TABLE 8.1.1. Non‐comprehensive List of Obstacles Observed (or to Be Encountered) ...TABLE 8.1.2. Common Molecules Used for Cation‐Conferration onto the Dispersed Oil...TABLE 8.1.3. Specifications for Commercially Successful Cationic Nanosized Emulsi...

11 Chapter 8-2TABLE 8.2.1. Non‐comprehensive List of Syndromes Manageable by Fatty Acids (Oils)...TABLE 8.2.2. General Physical Properties of Fish OilTABLE 8.2.3. Effect/Performance of Fish Oil Based on Positive Therapeutic Interve...TABLE 8.2.4. Effect/Performance of Fish Oil Based on Negative Therapeutic Interve...TABLE 8.2.5. Brief Introduction, Advantages and Drawbacks of Different Green‐Extr...TABLE 8.2.6. Marketed Intravenous Fat Emulsions Prepared Based on Fish Oil (FO), ...

1 Chapter 1 Flowchart 1.1. API sub‐categorization. Flowchart 1.2. Critical factors to determine long‐term product stability. Figure 1.1. Influence of emulsion droplet radius on steric stabilization.... Figure 1.2. Classification of oil‐in‐water (o/w) nanosized emulsions based o...

2 Chapter 2 Figure 2.1. Freeze‐dried emulsions using different cryo‐ or lyo‐protectants ... Figure 2.2. Amount of major proteins on the 2‐D gels of plasma proteins adso... Figure 2.3. Schematic diagram for preparation of nanosized emulsion. Flowchart 2.1. Typical steps involved for the new drug products during their... Flowchart 2.2. Evolution of QbD and multidimensional combination and interac... Figure 2.4. Ishikawa fish‐bone diagram made with the help of Minitab 18 soft... Figure 2.5. Half‐normal and Pareto charts for screening of influential formu... Figure 2.6. Response surface plots showing the interaction effects of castor... Figure 2.7. Derived plots obtained from 3D‐response surface model: residual ...

3 Chapter 3 Flowchart 3.1. Non‐exhaustive list of serially or systematically arranged va... Figure 3.1. Influence of 6 months storage temperature (4, 25, and 37°C) cond... Figure 3.2. Density‐ and gravitational force‐dependent/induced physical inst... Figure 3.3. Structure of cyclosporine A.Figure 3.4. Pictorial representation to show the behavior of charged dispers...Figure 3.5. Essential parts of transmission electron microscope.Figure 3.6. TEM images of emulsion samples taken at each one of the particle...Figure 3.7. 2D and 3D AFM topography of seaweed oil nanosized emulsions.Figure 3.8. Turbiscan ®assembly. Key: (a) Optical scanning analyser, Tu...Figure 3.9. Assessment of colloidal dispersion using Turbiscan ®. Key: (...Figure 3.10. Dynamic contact angle measurement and base width of an eye drop...Figure 3.11. In vitro release of celecoxib (CXB) through cellulose acetate m...Figure 3.12. In vitro cyclosporin A (CsA) release behavior at 1 : 2.5 diluti...Figure 3.13. Azithromycin (AZM) leakage percentage observed following the st...Figure 3.14. Acetazolamide (ACZM) amount (microgram) permeated through goat ...Figure 3.15. Skin retention of celecoxib (CXB) from solution and anionic and...Figure 3.16. Cumulative creatine kinase (CK) release from 150 mg of the isol...Figure 3.17. Mean plasma creatine kinase (CK) levels versus time following t...Figure 3.18. Hemolysis of sheep erythrocytes induced by free AZM (number 1 i...

4 Chapter 4Flowchart 4.1. Year‐wise positioning of oil‐in‐water nanosized emulsions.Flowchart 4.2. Monocytes and various subsets of tissue macrophages.Figure 4.1. Hypothetical representation of enhanced permeability and retenti...Figure 4.2. Schematic structure of the assembly of the multifunctional nanos...Figure 4.3. Oil‐in‐water nanosized emulsion preparation by de novo method.

5 Chapter 5Figure 5.1. 2‐D PAGE gel with protein adsorption pattern of Lipofundin MCT 1...Figure 5.2. Silver‐stained 2‐D PAGE gels of emulsions with different surface...

6 Chapter 7-2Figure 7.2.1. Schematic representation of droplet size growth over time in f...

7 Chapter 7-3Flowchart 7.3.1. Classification of o/w nanosized emulsions based on internal...Figure 7.3.1. Formation of Janus structure on the dispersed oil droplets of ...Figure 7.3.2. Optical microscopic picture showing the Janus structure on the...Figure 7.3.3. Emulsion with Cerberus structure on the dispersed oil droplets...Figure 7.3.4. Overview of current mouse models of atherosclerosis. This figu...

8 Chapter 7-4Flowchart 7.4.1. Classification of emulsion‐like dispersions.Figure 7.4.1. Schematic ternary phase diagrams, which illustrate (a) segrega...Figure 7.4.2. Schematic representation of the phase diagram. Concentrations ...

9 Chapter 8-2Flowchart 8.2.1. Commonly available various types of fish oil and their sour...

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2 Table of Contents

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