Nanopharmaceutical Advanced Delivery Systems

1 Cover

2 Title page

3 Copyright

4 Preface

5 Part 1: INTRODUCTION TO THE FUNDAMENTALS 1 Lipid-Based Nanocarriers as Drug Delivery System and Its Applications List of Abbreviation 1.1 Introduction 1.2 An Overview on Nanocarriers 1.3 Types of Nanocarriers 1.4 Methods of Preparation of Lipid Nanocarriers 1.5 Challenges and Hurdles 1.6 Characterization Techniques for Lipid Nanocarriers 1.7 Application of Lipid-Based Nanocarriers 1.8 Conclusion References 2 Nanoparticulate Carriers—Versatile Delivery Systems List of Abbreviations 2.1 Introduction 2.2 Classification of Nanoparticulate Carriers 2.3 Various Applications of Nanoparticulate Carriers 2.4 Modes of Transport of Nanoparticulate Carriers 2.5 Conclusion References 3 Nanotools in Customized Drug Delivery System List of Abbreviations 3.1 Introduction 3.2 Concept of Personalized Medicines 3.3 Customized Nanotools and Their Benefits 3.4 Applications of Nanotechnology in Personalized Medicine 3.5 Future Perceptions 3.6 Conclusion References

6 Part 2: NOVEL AND MODERNIZED NANOSCALE DELIVERY SYSTEMS: REVOLUTIONARY PROGRESS IN THE FIELD OF PHARMACY 4 Dendrimers: Role in Novel Drug Delivery List of Abbreviations 4.1 Introduction 4.2 Components of Dendrimers 4.3 Synthesis of Dendrimers 4.4 Classification of Dendrimers 4.5 Properties of Dendrimers 4.6 Mechanism of Drug Entrapment in Dendrimers 4.7 Dendrimers as Delivery Agents 4.8 Conclusion References 5 Nanofibers in Drug Delivery List of Abbreviations 5.1 Introduction 5.2 Nanofiber as Oral Drug Delivery System 5.3 Nanofiber as Topical Drug Delivery System 5.4 Nanofiber as Parenteral Drug Delivery System 5.5 Nanofiber as Multimodal Drug Delivery System 5.6 Challenges and Future Perspective 5.7 Conclusion References 6 Microbubbles used for Drug Delivery System List of Abbreviations 6.1 Introduction 6.2 Structural Components of Microbubble 6.3 Methods of Preparation Microbubbles 6.4 Acoustic Nature of Microbubble 6.5 Characterizations of Microbubbles 6.6 Applications of Microbubbles 6.7 Conclusions and Future Prospective References 7 Virosomes: A Viral Envelope System Having a Promising Application in Vaccination and Drug Delivery System List of Abbreviations 7.1 Introduction 7.2 What are Virosomes? 7.3 Comparison of Virosomes With Liposomes 7.4 Methods of Preparation of Virosomes 7.5 Characterization of Virosomes 7.6 Applications of Virosomal Technology 7.7 Conclusion References 8 Nanocarriers: A Tool for Effective Gene Delivery List of Abbreviations 8.1 Introduction 8.2 Key Steps in Gene Delivery 8.3 Success and Existing Challenges for Gene Delivery 8.4 In Vitro and In Vivo Barriers Towards Successful Gene Transfer 8.5 Genetic Material That can be Delivered in Gene Therapy 8.6 Role of Nanocarriers in a Nucleic Acid Delivery 8.7 Nanocarriers used for Delivering Gene 8.8 Cellular Uptake of Nanocarriers and Their Fate Inside the Cell 8.9 Physicochemical Properties of Nanoparticles Affecting Their Uptake 8.10 Targeted Delivery of Genes Using Nanocarriers 8.11 Virosomes 8.12 Exosomes 8.13 Diseases Cured by Gene Therapy 8.14 Clinical Trials 8.15 Current Trends and Approved Products 8.16 Concluding Remarks References 9 Phytosomes—Nanoarchitectures’ Promising Clinical Applications and Therapeutics List of Abbreviations 9.1 Introduction 9.2 Structure of Phytosomes 9.3 Components of Phytosomes 9.4 Synthesis of Phytosomes 9.5 Characterization of Phytosomes 9.6 Absorption Mechanism of Phytosomes 9.7 Applications of Phytosomes 9.8 Recent Trends and Advancements in Phytosomal Delivery 9.9 Future Perspectives 9.10 Conclusion References 10 Saponin Stabilized Emulsion as Sustainable Drug Delivery System: Current Status and Future Prospects List of Abbreviations 10.1 Introduction 10.2 Saponins as Surfactant 10.3 Pharmaceutical Advantages 10.4 Conclusion and Future Prospects References 11 Mono and Multi-Stimuli Responsive Polymers: Application as Intelligent Nano-Drug Delivery Systems List of Abbreviations 11.1 Introduction 11.2 Smart or Stimuli-Responsive Polymers for Drug Delivery 11.3 Dual and Multi-Stimuli Responsive Drug Delivery Systems 11.4 Conclusion References 12 An Insight into Nanosomes: Potential Nanopharmaceutical Delivery System List of Abbreviations 12.1 Introduction 12.2 General Methods of Preparation of Nanosomes and Drug Loading 12.3 Trafficking Mechanism in the Body 12.4 Sterilization of Nanosomes 12.5 Evaluation Parameters 12.6 Applications 12.7 Conclusion References 13 Nano-Structures as Bioelectronics for Controlled Drug Delivery List of Abbreviations 13.1 Introduction 13.2 Electroactive Biopolymer 13.3 Electrochemical Desorption From Micro and Nanostructures of Conductive Polymers 13.4 Electrochemical Desorption From Micro and Nano-Composites of Conductive Polymers 13.5 Electrochemical Desorption of Self-Assembled Monolayer From a Gold Surface 13.6 Electrochemically Actuated Release of Biochemicals 13.7 Biochemical Release Controlled by Electrochemical Erosion of Electrolyte Hydrogel and Nanofilm 13.8 Biochemical Release by Electrochemical and Electrothermal Erosion of Metallic Sealing Membranes 13.9 Release of Biochemicals by Fluidic Nano-Pumps and Rotating Nano-Motors Powered by Electric Fields 13.10 Conclusion and Future Aspects References 14 Bioadhesive Nanoparticulate Drug Delivery System List of Abbreviations 14.1 Introduction 14.2 Mucous Membrane 14.3 Mucoadhesive Forces 14.4 Theories of Mucoadhesion 14.5 Mechanism of Mucoadhesion 14.6 Polymers Used to Prepare Mucoadhesive Nanoparticles 14.7 Ideal Properties of Mucoadhesive Polymers 14.8 Mucoadhesion of Nanoparticles 14.9 Preparation Methods of Mucoadhesive Polymeric Nanoparticles 14.10 Evaluation of Mucoadhesive Systems 14.11 Evaluation Tests of Mucoadhesive Nanoparticulate Systems 14.12 Applications 14.13 Conclusion References

7 Part 3: UNDERSTANDING TARGETED DELIVERY SYSTEMS 15 Nanopharmaceuticals: An Approach for Effective Management of Breast Cancer List of Abbreviations 15.1 Introduction 15.2 Stages of Breast Cancer 15.3 Main Types of Breast Cancer 15.4 Drawbacks in Conventional Treatment 15.5 Nanoparticulate Approach for Effective Management of Breast Cancer 15.6 Systematic Drug Delivery System Approaches 15.7 Nanoparticles Targeted Drug Delivery 15.8 Various Ligands used for Targeting Cancer Cells 15.9 New Innovative Pharmaceutical Entities and Targeting Moieties 15.10 Future of Cancer Treatment in Nanotechnology 15.11 Conclusion References 16 Vaginal Nano-Based Drug Delivery System List of Abbreviations 16.1 Introduction 16.2 Vaginal Anatomy Physiology and Diseases of Vagina 16.3 Advantages of Vaginal Drug Delivery 16.4 Drawbacks of Conventional Vaginal Formulation 16.5 Need of Nanocarriers for Vaginal Delivery 16.6 Different Types of Nanoparticles for Vaginal Therapy 16.7 Vaginal Patents 16.8 Nanotoxicity: Future Prospective 16.9 Conclusion References 17 Recent Advances in Polymer-Modified Liposomes for Cancer Treatment List of Abbreviations 17.1 Introduction 17.2 Liposomes 17.3 Future Challenges Associated With Cancer Therapy 17.4 Conclusion References 18 Role of Nanomedicines in Neglected Tropical Diseases List of Abbreviations 18.1 Introduction 18.2 Diseases 18.3 Conclusion Acknowledgement References

8 Part 4: OVERVIEW OF REGULATORY AFFAIRS 19 Current Framework, Ethical Consideration and Future Challenges of Regulatory Approach for Nano-Based Products List of Abbreviations 19.1 Introduction 19.2 Issues in Aspect of Regulation of Drug Delivery System 19.3 Regulation of Nano-Based Products in Global Realms of the World 19.4 Regulatory Challenges and Solutions in DDS Development 19.5 Regulatory Education and its Involvement in Pharmaceutical Industry for the Development of Novel Drug Delivery Systems 19.6 Current Framework and Future Challenges 19.7 Conclusion References

9 Index

10 End User License Agreement