David Machin - Randomised Clinical Trials

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Second Edition

David Machin

Leicester Cancer Research Centre

University of Leicester, Leicester, UK

Medical Statistics Group, School of Health and Related Research

University of Sheffield, Sheffield, UK

Peter M. Fayers

Institute of Applied Health

University of Aberdeen, Scotland, UK

Bee Choo Tai

Saw Swee Hock School of Public Health

National University of Singapore and National University Health System Singapore

Singapore, Singapore

This edition first published 2021, © 2021 John Wiley & Sons Ltd

Edition History John Wiley & Sons, Ltd (1e, 2010)

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Library of Congress Cataloging‐in‐Publication Data

Names: Machin, David, 1939- author. | Fayers, Peter M., author. | Tai, Bee Choo, author.

Title: Randomized clinical trials : design, practice and reporting / David Machin, Peter M. Fayers, Bee Choo Tai.

Description: Second edition. | Hoboken, NJ : Wiley-Blackwell, 2021. | Includes bibliographical references and index.

Identifiers: LCCN 2020044539 (print) | LCCN 2020044540 (ebook) | ISBN 9781119524649 (paperback) | ISBN 9781119524656 (adobe pdf) | ISBN 9781119524670 (epub)

Subjects: MESH: Randomized Controlled Trials as Topic–methods | Biomedical Research–methods | Research Design | Data Interpretation, Statistical

Classification: LCC R853.C55 (print) | LCC R853.C55 (ebook) | NLM W 20.55.C5 | DDC 610.72/4–dc23

LC record available at https://lccn.loc.gov/2020044539LC ebook record available at https://lccn.loc.gov/2020044540

Cover Design: Wiley

Cover Image: © Kenishirotie/Shutterstock

To

Lorna Christine Machin

Tessa and Emma Fayers

Isaac Xu‐En and Kheng‐Chuan Koh