Genetic Analysis of Complex Disease

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Genetic Analysis of Complex Diseases
An up-to-date and complete treatment of the strategies, designs and analysis methods for studying complex genetic disease in human beings Genetic Analysis of Complex Diseases
Genetic Analysis of Complex Diseases
Genetic Analysis of Complex Diseases

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5 Chapter 7Figure 7.1 Data normalization example for dataset with information mapping S...

6 Chapter 8Figure 8.1 Decay of allelic association for recombination fractions (Θ) of 0...Figure 8.2 An example of haplotype blocks in a 100 kb region on chromosome 1...Figure 8.3 Transmitted and non‐transmitted alleles in a family triad.Figure 8.4 Example of scoring a TDT family.

7 Chapter 9Figure 9.1 Example of raw genotype intensity clusters for a single SNP. Imag...Figure 9.2 A flowchart overview of the entire GWAS QC process. Each topic is...Figure 9.3 Example of a principal components analysis plot – visualizing the...Figure 9.4 Example of two Q‐Q plots for a GWAS dataset. The image on the lef...

8 Chapter 10Figure 10.1 Tsne visualization of methylation array data clusters for pediat...Figure 10.2 View from the UCSC genome browser of a segment of the CTNNA2 gen...

9 Chapter 11Figure 11.1 Genotype models. Given a single biallelic variant, there are thr...

Guide

1 Cover Page

2 Title Page

3 Copyright Page

4 List of Contributors

5 Foreword

6 Table of Contents

7 Begin Reading

8 Index

9 Wiley End User License Agreement

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Genetic Analysis of Complex Diseases

Third Edition

Edited by William K. Scott and Marylyn D. Ritchie

This third edition first published 2022 2022 John Wiley Sons Inc Edition - фото 1

This third edition first published 2022

© 2022 John Wiley & Sons, Inc.

Edition History 2nd edition © 2006 by John Wiley & Sons, Inc. All rights reserved.

All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, except as permitted by law. Advice on how to obtain permission to reuse material from this title is available at http://www.wiley.com/go/permissions.

The right of William K. Scott and Marylyn D. Ritchie to be identified as the authors of the editorial material in this work has been asserted in accordance with law.

Registered Office John Wiley & Sons, Inc., 111 River Street, Hoboken, NJ 07030, USA

Editorial Office 9600 Garsington Road, Oxford, OX4 2DQ, UK For details of our global editorial offices, customer services, and more information about Wiley products visit us at www.wiley.com.

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Limit of Liability/Disclaimer of Warranty The contents of this work are intended to further general scientific research, understanding, and discussion only and are not intended and should not be relied upon as recommending or promoting scientific method, diagnosis, or treatment by physicians for any particular patient. In view of ongoing research, equipment modifications, changes in governmental regulations, and the constant flow of information relating to the use of medicines, equipment, and devices, the reader is urged to review and evaluate the information provided in the package insert or instructions for each medicine, equipment, or device for, among other things, any changes in the instructions or indication of usage and for added warnings and precautions. While the publisher and authors have used their best efforts in preparing this work, they make no representations or warranties with respect to the accuracy or completeness of the contents of this work and specifically disclaim all warranties, including without limitation any implied warranties of merchantability or fitness for a particular purpose. No warranty may be created or extended by sales representatives, written sales materials or promotional statements for this work. The fact that an organization, website, or product is referred to in this work as a citation and/or potential source of further information does not mean that the publisher and authors endorse the information or services the organization, website, or product may provide or recommendations it may make. This work is sold with the understanding that the publisher is not engaged in rendering professional services. The advice and strategies contained herein may not be suitable for your situation. You should consult with a specialist where appropriate. Further, readers should be aware that websites listed in this work may have changed or disappeared between when this work was written and when it is read. Neither the publisher nor authors shall be liable for any loss of profit or any other commercial damages, including but not limited to special, incidental, consequential, or other damages.

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