Principles in Microbiome Engineering

Love, J. Ch. (ed.)

Micro‐ and Nanosystems for Biotechnology

2016

Print ISBN: 978‐3‐527‐33281‐6

Wittmann, Ch., Liao, J.C. (eds.)

Industrial Biotechnology Microorganisms (2 Volumes)

2017

Print ISBN: 978‐3‐527‐34179‐5

Wittmann, Ch., Liao, J.C. (eds.)

Industrial Biotechnology Products and Processes

2017

Print ISBN: 978‐3‐527‐34181‐8

Nielsen, J., Hohmann, S. (eds.)

Systems Biology

2017

Print ISBN: 978‐3‐527‐33558‐9

Smolke, C.

Synthetic Biology

Parts, Devices, and Applications

2018

Print ISBN: 978‐3‐527‐33075‐1

Chang, H. N

Emerging Areas in Bioengineering

2018

Print ISBN: 978‐3‐527‐34088‐0

Lee, M. L., Kildgaard, H. F.

Cell Culture Engineering Recombinant Protein Production

2019

Print ISBN: 978‐3‐527‐81140‐3

Rehm. B. H. A., Moradali, M. F.

Biopolymers for Biomedical and Biotechnological Applications

2021

Print ISBN: 978‐3‐527‐34530‐4

Hudson, P.

Cyanobacteria Biotechnology

2021

Print ISBN: 978‐3‐527‐34714‐8

Lee, S.Y., Nielsen, J., Stephanopoulos, G. (Eds.)

Metabolic Engineering

2021

Print ISBN: 978‐3‐527‐34662‐2

Edited by

Matthew W. Chang

Volume Editor

Prof. Dr. Matthew W. ChangNational University of Singapore Department of Biochemistry 28 Medical Drive 117456 Singapore Singapore

Series Editors

Prof. Dr. Sang Y. LeeKAIST 373‐1, Guseong‐Dong 291 Daehak‐ro, Yuseong‐gu 34141 Daejeon South Korea

Prof. Dr. Jens NielsenChalmers University Department of Chemical and Biological Engineering Kemivägen 10 412 96 Göteborg Sweden

Prof. Dr. Gregory StephanopoulosMassachusetts Institute of Technology Department of Chemical Engineering Massachusetts Ave 77 Cambridge, MA 02139 United States

Cover Image:© shutterstock

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Print ISBN:978‐3‐527‐34725‐4 ePDF ISBN:978‐3‐527‐82547‐9 ePub ISBN:978‐3‐527‐82548‐6 oBook ISBN:978‐3‐527‐82546‐2

Cover DesignAdam-Design, Weinheim, Germany

Though unseen to the naked eye, microbiomes represent an invisible universe with much yet to be explored. From the diverse microbial communities found within our own bodies all the way to the soil's depths, the omnipresence of these microbiomes underlies their vital role in mediating biological processes. By offering a means to harness these microbes for societal benefit, microbiome engineering can pave the way for crucial interventions in everything from disease treatment to agricultural productivity.

Given the intricacy of interactions among microbes, it would be wise to comprehensively compile our state‐of‐the‐art knowledge on microbiome engineering. Written by leading experts, the volume's 10 chapters touch upon fundamental aspects – such as the microbiome's wide‐ranging influence on human health, disease, and agriculture; methods to engineer microbiomes for therapeutic and diagnostic applications, as well as insights into recent research directions that are shaping the field.

With probiotics capturing public imagination in recent years, Chapter 1aptly introduces our current understanding of the human microbiome through the lens of diet and nutrition. Chapter 2builds upon this foundation by exploring how microbiome engineering can modulate common metabolic disorders from diabetes to cardiovascular disease.

While microbes are popularly perceived as “villains” in the quest for health, Chapter 3challenges this notion by describing the myriad ways microbes can be repurposed to sense, respond to, and even treat diseases. Rounding out the volume's initial focus on human health, Chapter 4details specific considerations when engineering probiotics to be better adapted to the gut.

Chapter 5moves onto another equally fascinating – and important – application of microbiome engineering: precision agriculture, where minute variations in crop data are gathered and leveraged to improve yield and quality. Given the delicate balance of microbiomes, Chapter 6provides an overview of the different biological sensors being developed to detect even the slightest of perturbations, such as riboswitches and transcription factors.

Meanwhile, Chapter 7focuses on how synergistic interactions among microorganisms can be further enhanced by engineering synthetic microbial consortia. Already ubiquitous in nature, advancing the design of microbial consortia could lead to breakthroughs in bioprocessing and bioremediation, among others. Proving that waste can indeed be turned into wonder, Chapter 8describes the emerging treatment that is fecal microbiota transplantation, from the protocols involved to its clinical applications.

With early‐life microbiota increasingly linked to long‐term health and disease, Chapter 9shines a spotlight on the maternal microbiota and the many factors affecting its impact on newborn infants. Finally, this volume concludes in Chapter 10by diving deep into a powerful technique in the microbiome engineering toolkit: transcription factor‐based biosensors, first introduced in Chapter 6.

I would like to extend my deepest gratitude to the experts at the forefront of microbiome engineering for their contributions. By sharing their insights through the written word, I hope that this volume will be an indispensable resource that new generations of researchers can refer to as they add to the growing body of knowledge on microbiome engineering.

Jiashu Li, Zeyang Qu, Feng Liu, Hao Jing, Yu Pan, Siyu Guo and Chun Loong Ho