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Робин Кук: Intervention

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Робин Кук Intervention
  • Название:
    Intervention
  • Автор:
  • Издательство:
    G. P. Putnam’s Sons
  • Жанр:
  • Год:
    2009
  • Город:
    New York
  • Язык:
    Английский
  • ISBN:
    978-0-399-15570-3
  • Рейтинг книги:
    4 / 5
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Intervention: краткое содержание, описание и аннотация

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It’s been more than thirty years since New York City medical examiner Jack Stapleton’s college graduation, and almost as long since he’s been in touch with former classmates Shawn Daughtry and James O’Rourke. Jack was once a highly regarded ophthalmologist, but his career took a dramatic turn after a tragic accident destroyed his family. And that, too, is very much in the past: Jack has remarried — to longtime colleague and fellow medical examiner Laurie Montgomery — and his the father of a young child, who unfortunately has been diagnosed with neuroblastoma, a childhood cancer. No matter what stresses he faces, Jack’s renegade, activist personality can’t rest. After performing a postmortem on a promising young college graduate who had recently been treated by a chiropractor, Jack begins researching alternative medicine as a way to avoid obsessing about his child’s illness. Quickly he is confronted by the question of what makes some people step outside the medical establishment to seek help from therapies based on dubious science, Eastern philosophies or even faith healers. Jack’s classmate Shawn Daughtry is now a renowned archaeologist and biblical scholar. Brash, impetuous, and completely career-driven, Shawn makes a spectacular find at a souk in Cairo: an ancient codex, whose contents may vault him to international fame. His discovery takes him on a secret journey to what is held to be Saint Peter’s tomb beneath the basilica in Rome, where he hopes to unearth a two-thousand-year-old ossuary, the contents of which may have earthshaking ecclesiastical and medical implications. Shawn can’t wait to flaunt his treasure before his old college buddy James O’Rourke — now James Cardinal O’Rourke, bishop of the Archdiocese of New York: the treasure may jeopardize the very nature of papal infallibility. Desperate to protect his church and his own political ambitions, James turns to his friend Jack to help safeguard an explosive secret, one with the power to change lives forever.

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The baby’s room was gently lit by several night-lights at baseboard level. Hesitantly, Jack approached the white eyelet-swathed bassinet. The last thing he wanted to do was wake the baby. Getting him back to sleep after the last feeding had been a struggle. With little of the night-lights’ illumination reaching into the depths of the bassinet, Jack couldn’t see much. The baby was on his back, hands splayed out to the sides at forty-five-degree angles. His fingers were clenched over each thumb. Some light glinted off the child’s forehead. His eyes were lost in shadow, but Jack knew that beneath them were dark circles, one of the early symptoms of his problem. The dark skin had developed slowly over a period of weeks, and neither Jack nor Laurie had really noticed it. It was Dorothy who’d brought it to their attention. Other symptoms gradually made their presence known. What was initially termed “fussiness” by the unsuspecting pediatrician rapidly developed into sleepless nights for the entire Stapleton household.

When the diagnosis was finally made, Jack felt as if the wind had been knocked out of him, as if he’d been hit in the stomach with a baseball bat. The blood drained from his brain so dramatically that he’d had to grasp the arms of the chair he’d been sitting in to keep from falling to the floor. All his worst anxieties came true. His fear of a curse on his loved ones, particularly children, was alive and well. John Junior had been diagnosed with neuroblastoma, a disease responsible for fifteen percent of cancer deaths in children. Even worse, the cancer had widely metastasized, the malignancy spreading throughout JJ’s body and into his bones and central nervous system. John Junior had what was termed high-risk neuroblastoma, the worst kind.

The next months had been pure hell for the new parents as the diagnosis grew more dire and a treatment plan was determined. Luckily for John Junior, Laurie had remained remarkably clear-headed during that time, particularly those first few crucial days, while Jack struggled to keep from falling into the same emotional and mental abyss he had years earlier. Knowing that John Junior and Laurie really needed him had saved the day. With great effort Jack fought off the overwhelming guilt and anger and was able to be a reasonably positive force.

It had not been easy, but the Stapletons were fortunate to be referred to the neuroblastoma program at the Memorial Sloan-Kettering Cancer Center, where they quickly came to rely on the professionalism, experience, and empathy of the talented staff. Over a several-month period, JJ underwent multiple courses of individualized chemotherapy, each requiring hospital admission, for troublesome side effects. When the chemotherapy had achieved what they thought was the desired result, JJ was started on a relatively new and promising treatment involving the intravenous injection of a mouse-generated monoclonal antibody to the neuroblastoma cells. The antibody, called 3F8, sought out the cancer cells and helped the patient’s immune system destroy them. At least that was the theory.

The original treatment protocol had been to continue two-week cycles of daily infusions over a number of months, or perhaps a year, if possible. Unfortunately, after only a few cycles, the treatment had to be stopped. John Junior’s immune system, despite the previous chemotherapy, had developed an allergy to the mouse protein, causing a dangerous side effect. The new plan was to wait a month or two, then recheck John Junior’s sensitivity to the mouse protein. If it dropped low enough, treatment would start again. There was no other option. John Junior’s disease was too widespread for autologous stem-cell therapy, surgery, or radiation.

“He’s so darling when he’s asleep and not crying,” a voice said in the darkness.

Jack started. Caught up in his thoughts, he’d been unaware that Laurie had come up alongside him.

“I’m sorry to have startled you,” Laurie added, looking up at her husband.

“I’m sorry to have awakened you,” Jack said sympathetically. Given the demanding circumstances involving JJ’s care, he knew she was chronically exhausted.

“I was already awake when you jolted yourself awake. I was afraid you were having another nightmare, with your rapid breathing.”

“I was. It was my old runaway-car dream, only this time I was hurtling toward a group of preschool children. It was terrible.”

“I can imagine. At least it’s not hard to interpret.”

“You think so,” Jack said with a touch of sarcasm. He wasn’t fond of being psychoanalyzed.

“Now, don’t get your dander up,” Laurie added. She reached out and grasped Jack’s upper arm. “For the hundredth time, JJ’s illness is not your fault. You have to stop beating up on yourself.”

Jack took a deep breath and let it out noisily. He shook his head. “It’s easy for you to say.”

“But it’s true!” Laurie insisted, giving Jack’s arm an empathetic squeeze. “You know what the doctors at Memorial said when we pressured them for an etiology. Hell, it’s more likely it was I, considering the chemicals we’re exposed to as forensic pathologists. When I was pregnant, I tried to avoid all solvents, but it was impossible.”

“Solvents as the cause of neuroblastoma has not been proven.”

“It’s not proven, but it’s a hell of a lot more likely than the supernatural curse you keep torturing yourself with.”

Jack reluctantly nodded. He was afraid of where the conversation was going. He didn’t like to talk about his curse as he didn’t believe in the supernatural, nor was he particularly religious, two beliefs he thought related. He preferred to keep to his immediate reality, things that he could touch and feel and generally appreciate with his own senses.

“What about my taking fertility drugs?” Laurie said. “That was another one of the doctor’s suggestions. Do you remember?”

“Of course I remember,” Jack admitted testily. He didn’t want to talk about the issue.

“The truth is that the cause of neuroblastoma is not known, period! Listen, just come back to bed.”

Jack shook his head. “I’d never fall back asleep. Besides, it’s got to be close to five. I might as well shower and shave, and head in to work early. I need something to keep my mind busy.”

“An excellent idea,” Laurie agreed. “I wish I could do the same.”

“We’ve talked about it, Laurie. You could go back to work. We’d hire nurses. Maybe it would be better for you.”

Laurie shook her head. “You know me, Jack. I couldn’t. I have to see this through, no matter what. I’d never forgive myself.” She looked down at the seemingly peaceful sleeping baby, his slightly bulging eyes thankfully lost in shadow. She caught her breath as a sudden rush of emotion overtook her, as it unpredictably did on occasion. She’d wanted a child so much. She never imagined she’d have a child who’d suffer as much as JJ, and yet he was only four months old. She too struggled with guilt, but unlike Jack, she’d found at least some solace in religion. She’d been brought up a Catholic, now lapsed. Still, she wanted to believe in God, did so in a vague way, and managed to think of herself as a Christian. She secretly prayed for JJ, but at the same time, she couldn’t understand how a supreme being would allow evil like children’s cancer, particularly neuroblastoma, to exist.

Jack detected the change in Laurie’s state of mind from the sound of her breathing. Choking back tears himself, he put his arm over his wife’s shoulder and followed her line of sight back down to John Junior.

“The hardest thing for me at this point,” Laurie managed, wiping away tears, “is the feeling that we are treading water. Right now, while we wait for his allergy to mouse protein to abate, we’re not treating him. Orthodox medicine has, in a way, abandoned us. It’s so frustrating! I felt so positive when we started the monoclonal antibody. It made so much more sense to me than the shotgun approach with chemotherapy, especially for a rapidly growing infant. Chemo goes after every growing cell, while the antibody goes after only the cancer cells.”

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