Blood and Marrow Transplantation Long Term Management

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Hematopoietic cell transplantation (HCT) provides curative therapy for a variety of diseases. Over the past several decades, significant advances have been made in the field of HCT, to the point where HCT has become an integral part of treatment modality for a variety of hematologic malignancies and some nonmalignant diseases. HCT remains an important treatment option for a wide variety of hematologic and nonhematologic disorders, despite recent advances in the field of immunologic therapies. Factors driving this growth include expanded disease indications, greater donor options (expanding unrelated donor registries and haploidentical HCT), and accommodation of older and less fit recipients. 
The development of less toxic pretransplant conditioning regimens, more effective prophylaxis of graft-versus-host disease (GVHD), improved infection control, and other advances in transplant technology have resulted in a rapidly growing number of transplant recipients surviving long-term free of the disease for which they were transplanted. The changes over decades in the transplant recipient population and in the practice of HCT will have almost inevitably altered the composition of the long-term survivor population over time. Apart from an increasingly older transplant recipient cohort, the pattern of transplant indications has shifted from the 1990s when chronic myeloid leukemia made up a significant proportion of allo-HCT indications. Changes in cell source, donor types, conditioning regimens, GVHD prophylaxis, and supportive care have all occurred, with ongoing reductions in both relapse and non-relapse mortality (NRM) have been demonstrated. 
These patients have increased risks for a variety of late complications, which can cause morbidity and mortality. Most long-term survivors return to the care of their local hematologists/oncologists or primary care physicians, who may not be familiar with specialized monitoring and management of long complications after HCT for this patient population. As HCT survivorship increases, the focus of care has shifted to the identification and treatment of long-term complications that may affect quality of life and long-term morbidity and mortality. 
Preventive care as well as early detection and treatments are important aspects to reducing morbidity and mortality in long-term survivors after allo-HCT. This second edition, 
, provides up-to-date information about diagnosis, screening, treatment, and long-term surveillance of long-term survivors after HCT.

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Betty K. Hamilton MDBlood and Marrow Transplant Program Taussig Cancer Institute Cleveland Clinic Cleveland, OH, USA

Shahrukh K. Hashmi MD, MPHDivision of Blood and Marrow Transplantation William J. von Liebig Transplant Center Mayo Clinic Rochester, MN, USA

Theo Heller MDTranslational Hepatology Unit Liver Disease Branch National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) National Institutes of Health Bethesda, MD, USA

Sangeeta Hingorani MDUniversity of Washington Children's Hospital and Regional Medical Center Seattle, WA, USA

Jenny Hoag PhDMedical College of Wisconsin Department of Pediatrics Division of Hematology/Oncology/Bone Marrow Transplant Milwaukee, WI, USA

Sanghee Hong MDBlood and Marrow Transplant Program Cleveland Clinic Cleveland, OH, USA

Aasha I. Hoogland PhDDepartment of Health Outcomes and Behavior Moffitt Cancer Center Tampa, FL, USA

Rebecca L. Hunter PhDDivision of Hematology University of Colorado Anschutz Medical Center Aurora, CO, USA

Heather S. L. Jim PhDDepartment of Health Outcomes and Behavior Moffitt Cancer Center Tampa, Florida, USA

Annika Kisch RN, PhDDepartment of Haematology Skåne University Hospital Institute of Health Sciences at Lund University Lund, Sweden

Christopher Koh MD, MHSLiver Disease Branch National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) National Institutes of Health Bethesda, MD, USA

Minako Iida MDDepartment of Promotion for Blood and Marrow Transplantation Aichi Medical University School of Medicine Nagakute, Japan

Yoshihiro Inamoto MDDepartment of Hematopoietic Stem Cell Transplantation National Cancer Center Hospital Tokyo, Japan

Shubhuda Jagasia MD MMHCVanderbilt Eskind Diabetes Clinic Inpatient diabetes and Endocrinology Division of Diabetes, Endocrinology and Metabolism Vanderbilt University Medical Center Nashville, TN, USA

Catherine J. Lee MDUtah Blood and Marrow Transplant Program Huntsman Cancer Institutet Salt Lake City, UT, USA

Per Ljungman MD, PhDDepartment for Cellular Therapy and Allogeneic Stem Cell Transplantation Karolinska University Hospital Huddinge Division of Hematology Department of Medicine Huddinge Karolinska Institutet Stockholm, Sweden

Melissa Logue ANP‐BCHematology and Stem Cell Transplantation Section Division of Hematology/Oncology Department of Medicine Vanderbilt University Medical Center Nashville, TN, USA

Alison W. Loren MD, MSCEBlood & Marrow Transplantation Abramson Cancer Center University of Pennsylvania Pennsylvania, PA, USA

Catherine E. Lucid ACNP‐BC, MSNHematology and Stem Cell Transplantation Section Division of Hematology/Oncology Vanderbilt University Medical Center Nashville, TN, USA

Kristy Luke NPSection of Bone Marrow Transplant and Cellular Therapy Rush University Medical Center Chicago, IL, USA

Enrico Maffini MDDepartment of Oncology AOU Città della Salute e della Scienza di Torino Department of Molecular Biotechnology and Health Sciences University of Torino, Torino, Italy

Navneet S. Majhail MD, MSBlood and Marrow Transplant Program Cleveland Clinic Taussig Cancer Institute Cleveland, OH, USA

Leslee Matheny MDDivision of Diabetes, Endocrinology & Metabolism Vanderbilt University Medical Center Nashville, TN, USA

Juliana Matthews MDDivision of Diabetes, Endocrinology & Metabolism Vanderbilt University Medical Center Nashville, TN, USA

David Michonneau MD, PhDHematology Transplantation APHP Hospital Saint Louis and Université de Paris; Université de Paris & INSERM U976 Paris, France

Sandra A. Mitchell PhD, CRNP, AOCNOutcomes Research Branch Healthcare Delivery Research Program Division of Cancer Control and Population Sciences National Cancer Institute Bethesda, MD, USA

Emilee Moeke RNSection of Bone Marrow Transplant and Cellular Therapy Rush University Medical Center Chicago, IL, USA

Angela Moreschi Woods MSN APRN ACNP‐BCNational Marrow Donor Program Minneapolis, MN, USA

Ibrahim N. Muhsen MDDepartment of Medicine Houston Methodist Hospital and Weill Cornell Medical College Houston, TX, USA

Jeanne Murphy PhD, CNM, FACNMThe George Washington University Washington, DC, USA

Sunita Nathan MDSection of Bone Marrow Transplant and Cellular Therapy Rush University Medical Center Chicago, IL, USA

Shinichiro Okamoto MD, PhDDivision of Hematology Department of Medicine Keio University School of Medicine Tokyo, Japan

Attilio Olivieri MDClinica di Ematologia Department of molecular and clinical sciences Ancona University Ancona, Italy

Steven Pavletic MDImmune Deficiency Cellular Therapy Program Graft‐versus‐Host and Late Effects Section Center for Cancer Research National Cancer Institute National Institutes of Health Bethesda, MD, USA

Rachel PhelanCenter of International Blood and Marrow Transplant Research; Department of Medicine Medical College of Wisconsin Milwaukee, WI, USA

Jakob R. Passweg MDDivision of Hematology University Hospital Basel Basel, Switzerland

J. Douglas Rizzo MD, MSMedical College of Wisconsin and Center for International Blood and Marrow Transplant Research Milwaukee, WI, USA

Montserrat Rovira MD, PhDHospital Clinic Hematopoietic Cell Transplantation Program Barcelona, Spain

Alicia Rovó MDDepartment of Hematology and Central Hematology Laboratory Inselspital, Bern University Hospital Bern, Switzerland

Nina Salooja FRCPath MDDepartment of Medicine Imperial College London Hammersmith Hospital London, UK

Insara Jaffer Sathick MDRenal Service, Division of Medicine Memorial Sloan Kettering Cancer Center New York, NY, USA

Bipin N. Savani MDLong Term Transplant Clinic (LTTC), Hematology, Stem Cell Transplantation and Cellular Therapy Section, Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center and Veterans Affairs Medical Center, Nashville, TN, USA

Angela Scherwath PhDDepartment and Outpatient Clinic of Medical Psychology University Medical Center Hamburg – Eppendorf Hamburg, Germany

Hélène Schoemans MD, PhDDepartment of Hematology University Hospitals Leuven and KU Leuven Leuven, Belgium

Dana Shanis MD, FACOGVHealth & Wellness Philadelphia, PA, USA

Bronwen E. Shaw MD, PhDCenter of International Blood and Marrow Transplant Research; Department of Medicine Medical College of Wisconsin Milwaukee, WI, USA

Gérard Socié MD, PhDHematology TransplantationAPHP Hospital Saint Louis and Université de Paris; Université de Paris & INSERM U976 Paris, France

Ayman O. Soubani MDDivision of Pulmonary, Critical Care and Sleep Medicine Wayne State University School of Medicine Detroit, MI, USA

Katrina M. Stokes MSSW LCSWTennessee Valley Healthcare System Nashville, TN, USA

Pamela Stratton MDOffice of the Clinical Director National Institute for Neurological Disorders and Stroke Bethesda, MD, USA

Aurélien Sutra del Galy MDHematology Transplantation APHP Hospital Saint Louis and Université de Paris; Université de Paris & INSERM U976 Paris; France

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