Iain K. Crombie - Evidence in Medicine
Здесь есть возможность читать онлайн «Iain K. Crombie - Evidence in Medicine» — ознакомительный отрывок электронной книги совершенно бесплатно, а после прочтения отрывка купить полную версию. В некоторых случаях можно слушать аудио, скачать через торрент в формате fb2 и присутствует краткое содержание. Жанр: unrecognised, на английском языке. Описание произведения, (предисловие) а так же отзывы посетителей доступны на портале библиотеки ЛибКат.
- Название:Evidence in Medicine
- Автор:
- Жанр:
- Год:неизвестен
- ISBN:нет данных
- Рейтинг книги:5 / 5. Голосов: 1
-
Избранное:Добавить в избранное
- Отзывы:
-
Ваша оценка:
Evidence in Medicine: краткое содержание, описание и аннотация
Предлагаем к чтению аннотацию, описание, краткое содержание или предисловие (зависит от того, что написал сам автор книги «Evidence in Medicine»). Если вы не нашли необходимую информацию о книге — напишите в комментариях, мы постараемся отыскать её.
is a much-needed resource that addresses the ‘medical misinformation mess’ by assessing the flaws in the research environment. This authoritative text identifies and summarises the many factors that have produced the current problems in medical research, including bias in randomised controlled trials, questionable research practices, falsified data, manipulated findings, and more.
This volume brings together the findings from meta-research studies and systematic reviews to explore the quality of clinical trials and other medical research, explaining the character and consequences of poor-quality medical evidence using clear language and a wealth of supporting references. The text suggests planning strategies to transform the research process and provides an extensive list of the actions that could be taken by researchers, regulators, and other key stakeholders to address defects in medical evidence. This timely volume:
Enables readers to select reliable studies and recognise misleading research Highlights the main types of biased and wasted studies Discusses how incentives in the research environment influence the quality of evidence Identifies the problems researchers need to guard against in their work Describes the scale of poor-quality research and explores why the problems are widespread Includes a summary of key findings on poor-quality research and a listing of proposed initiatives to improve research evidence Contains extensive citations to references, reviews, commentaries, and landmark studies
is required reading for all researchers who create evidence, funders and publishers of medical research, students who conduct their own research studies, and healthcare practitioners wanting to deliver high-quality, evidence-based care.
Evidence in Medicine — читать онлайн ознакомительный отрывок
Ниже представлен текст книги, разбитый по страницам. Система сохранения места последней прочитанной страницы, позволяет с удобством читать онлайн бесплатно книгу «Evidence in Medicine», без необходимости каждый раз заново искать на чём Вы остановились. Поставьте закладку, и сможете в любой момент перейти на страницу, на которой закончили чтение.
Интервал:
Закладка:
Table of Contents
1 Cover
2 Title Page Evidence in Medicine The Common Flaws, Why They Occur and How to Prevent Them Iain K Crombie University of Dundee Dundee, Scotland, UK
3 Copyright Page
4 Preface
5 Aims of this Book REFERENCES
6 CHAPTER 1: The Rationale for Treatment THEORY AS JUSTIFICATION FOR TREATMENT TESTING ON A SERIES OF PATIENTS COMPARING GROUPS COMPARING SIMILAR GROUPS CASTING LOTS AND TREATMENT ALLOCATION RANDOM NUMBERS FOR TREATMENT ALLOCATION THE NEED FOR BLINDING CONCLUSION REFERENCES
7 CHAPTER 2: Sources of Bias in Randomised Controlled Trials METHOD OF TREATMENT ALLOCATION PROBLEMS IN MEASURING THE OUTCOME FOLLOW‐UP AND MISSING OUTCOMES MISSING OUTCOME DATA AND INTENTION TO TREAT OTHER METHODOLOGICAL CONCERNS CONCLUSIONS REFERENCES
8 CHAPTER 3: Wasted and Unhelpful Trials WASTED STUDIES NEGLECTED AREAS OF RESEARCH UNHELPFUL OUTCOME MEASURES LACK OF GENERALISABILITY WEAK AND MISLEADING EVIDENCE CONCLUSION REFERENCES
9 CHAPTER 4: Can the Analysis Bias the Findings? THE P‐VALUE PROBLEM QUESTIONABLE RESEARCH PRACTICES ENSURING HIGH QUALITY ANALYSIS: THE STATISTICAL ANALYSIS PLAN CONCLUSIONS REFERENCES
10 CHAPTER 5: Systematic Reviews and Meta‐AnalysisINTRODUCTION IDENTIFYING RELEVANT TRIALS EXTRACTING TRIAL DATA THE QUALITY OF PRIMARY TRIALS POOLING EFFECT SIZES ACROSS TRIALS OTHER METHODOLOGICAL ISSUES CONCLUSIONS REFERENCES
11 CHAPTER 6: Fabrication, Falsification and Spin FABRICATION FALSIFICATION QUESTIONABLE RESEARCH PRACTICES SPIN Drawing Misleading Conclusions RETRACTIONS DISCUSSION REFERENCES
12 CHAPTER 7: Why Do Researchers Falsify Data or Manipulate Study Findings? THE RESEARCH ENVIRONMENT RESEARCH OVERSIGHT CONFLICT OF INTEREST INDIVIDUAL LEVEL EXPLANATIONS FOR RESEARCH MISCONDUCT HOW HONEST PEOPLE RATIONALISE MISCONDUCT DISCUSSION REFERENCES
13 CHAPTER 8: Developing a Strategy to Prevent Poor Quality and Misleading Research RESEARCH ENVIRONMENT RESEARCH TRANSPARENCY RESEARCH OVERSIGHT RESEARCH INTEGRITY ESSENTIAL ELEMENTS OF A TRANSFORMATIONAL STRATEGY IMPLEMENTING A PROGRAMME FOR ACTION REFERENCES
14 Appendix 1: Summary of the Key Findings on Poor Quality Research PROBLEMS IN THE DESIGN, CONDUCT, ANALYSIS AND REPORTING OF STUDIES Statistical Analysis FREQUENCY OF DATA FABRICATION AND FALSIFICATION THE CAUSES OF POOR QUALITY AND MISLEADINGRESEARCH THE FINDINGS IN PERSPECTIVE REFERENCES
15 Appendix 2: Initiatives to Improve the Quality of Research CHANGE THE RESEARCH ENVIRONMENT INCREASE RESEARCH TRANSPARENCY QUALITY OF TRIAL METHODOLOGY TRIAL REGISTRATION REPORTING OF THE METHODS OF SYSTEMATIC REVIEWS INCREASING ACCESS TO AND USE OF REPORTING GUIDELINES IMPLEMENT VIGOROUS RESEARCH OVERSIGHT PROMOTE RESEARCH INTEGRITY EXAMPLES OF COORDINATED INITIATIVES REFERENCES
16 Index
17 End User License Agreement
List of Tables
1 Chapter 6TABLE 6.1 Frequency of questionable research practices.
Guide
1 Cover Page
2 Title Page Evidence in Medicine The Common Flaws, Why They Occur and How to Prevent Them Iain K Crombie University of Dundee Dundee, Scotland, UK
3 Copyright Page
4 Preface
5 Aims of this Book
6 Table of Contents
7 Begin Reading
8 Appendix 1: Summary of the Key Findings on Poor Quality Research
9 Appendix 2: Initiatives to Improve the Quality of Research
10 Index
11 Wiley End User License Agreement
Pages
1 iii
2 iv
3 ix
4 x
5 xi
6 xii
7 1
8 2
9 3
10 4
11 5
12 6
13 7
14 8
15 9
16 10
17 11
18 12
19 13
20 14
21 15
22 16
23 17
24 18
25 19
26 20
27 21
28 22
29 23
30 24
31 25
32 26
33 27
34 28
35 29
36 30
37 31
38 32
39 33
40 34
41 35
42 36
43 37
44 38
45 39
46 40
47 41
48 42
49 43
50 44
51 45
52 46
53 47
54 48
55 49
56 50
57 51
58 52
59 53
60 54
61 55
62 56
63 57
64 58
65 59
66 60
67 61
68 62
69 63
70 64
71 65
72 66
73 67
74 68
75 69
76 70
77 71
78 72
79 73
80 74
81 75
82 76
83 77
84 78
85 79
86 80
87 81
88 82
89 83
90 84
91 85
92 86
93 87
94 88
95 89
96 90
97 91
98 92
99 93
100 94
101 95
102 96
103 97
104 98
105 99
106 100
107 101
108 102
109 103
110 104
111 105
112 106
113 107
114 108
115 109
116 110
117 111
118 112
119 113
120 114
121 115
122 116
123 117
124 118
125 119
126 120
127 121
128 122
129 123
130 124
131 125
132 126
133 127
134 128
135 129
136 130
137 131
138 132
139 133
140 134
141 135
142 136
143 137
144 138
145 139
146 140
147 141
148 142
149 143
150 144
151 145
152 146
153 147
154 148
155 149
156 150
157 151
158 152
159 153
160 154
161 155
162 156
163 157
164 158
165 159
166 160
167 161
168 162
169 163
170 164
171 165
172 166
173 167
174 168
175 169
176 170
177 171
178 172
179 173
180 174
181 175
182 176
183 177
184 178
185 179
186 180
187 181
188 182
189 183
190 184
191 185
192 186
193 187
194 188
195 189
196 190
197 191
198 192
199 193
200 194
201 195
202 196
203 197
204 198
205 199
206 200
207 201
208 202
209 203
210 204
211 205
212 206
213 207
214 208
215 209
216 210
217 211
218 212
219 213
220 214
221 215
222 216
223 217
224 218
225 219
226 220
227 221
228 222
229 223
230 224
231 225
232 226
233 227
234 228
235 229
236 230
237 231
238 232
239 233
240 234
241 235
242 236
243 237
244 238
245 239
246 238
247 239
248 240
249 241
250 242
251 243
252 244
253 245
254 246
255 247
256 248
257 249
258 250
Evidence in Medicine
The Common Flaws, Why They Occur and How to Prevent Them
Iain K Crombie
University of Dundee
Dundee, Scotland, UK
This edition first published 2021
© 2021 John Wiley & Sons Ltd
All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, except as permitted by law. Advice on how to obtain permission to reuse material from this title is available at http://www.wiley.com/go/permissions.
The right of Iain K Crombie to be identified as the author of this work has been asserted in accordance with law.
Registered Office(s) John Wiley & Sons, Inc., 111 River Street, Hoboken, NJ 07030, USA John Wiley & Sons Ltd, The Atrium, Southern Gate, Chichester, West Sussex, PO19 8SQ, UK
Читать дальшеИнтервал:
Закладка:
Похожие книги на «Evidence in Medicine»
Представляем Вашему вниманию похожие книги на «Evidence in Medicine» списком для выбора. Мы отобрали схожую по названию и смыслу литературу в надежде предоставить читателям больше вариантов отыскать новые, интересные, ещё непрочитанные произведения.
Обсуждение, отзывы о книге «Evidence in Medicine» и просто собственные мнения читателей. Оставьте ваши комментарии, напишите, что Вы думаете о произведении, его смысле или главных героях. Укажите что конкретно понравилось, а что нет, и почему Вы так считаете.