Assisted Reproduction Techniques

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Assisted reproduction techniques have led to the birth of 8 million babies worldwide Assisted reproduction techniques (ART), in particular in-vitro fertilization and intra-cytoplasmic sperm injection, are the most advanced forms of infertility treatment. They involve numerous counseling, medical, surgical and laboratory-based steps. At each step various problems and complications could be encountered that challenge even the most experienced ART practitioners. Moreover, patients with complex medical disorders may require ART, presenting further challenges. 
Assisted Reproduction Techniques Written by 171 internationally renowned experts, 
 follows the patient's journey throughout the whole ART process, with chapters on: 
Counseling and preparation Pituitary suppression and ovarian stimulation Oocyte retrieval Embryo transfer The luteal phase The ART laboratory The male patient The ART pregnancy <li style="margin: 0in 0in 0in 0.75in; font-size: 11pt; font-family: Calibri, sans-serif; text-align: justify; vertical-align: baseline; user-select: text; -webkit-user-drag: none; -webkit-tap-highlight-color: transparent; cur

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14 SECTION FIVES: The luteal phase 68 Vaginal bleeding in the luteal phase after IVF Background Management options Prevention Answers to questions patients ask References 69 Pelvic infection after IVF Background Management options Prevention Answers to questions patients ask References 70 The patient presenting with ovarian hyperstimulation syndrome Background Management options Prevention Answers to questions patients ask References 71 Adnexal torsion after IVF Background Management options Prevention Answers to questions patients ask References 72 Exposure to infection in the luteal phase of IVF Background Management options Answers to questions patients ask References

15 SECTION SIX: The ART laboratory 73 Total failure of fertilization after conventional IVF – rescue ICSI Background Management options Prevention Answers to questions patients ask References 74 Couples not wishing to create surplus embryos in IVF Background Management options Prevention Answers to questions patients ask References 75 Routine preimplantation genetic testing for aneuploidy Introduction Management options Answers to questions patients ask References 76 Choosing an embryo for transfer Background Management options Answers to questions patients ask References 77 Globozoospermia Background Management options Answers to questions patients ask References 78 Total failure of fertilization after ICSI Background Management options Prevention Answers to questions patients ask References 79 Refreezing of embryos Background Management options Clinical application Answers to questions patients ask References 80 Infection in embryo culture medium Background Management options Prevention Answers to questions patients ask References 81 ICSI or IVF for nonmale‐factor infertility? Background Management options Answers to questions patients ask References 82 Cryostorage failure in ART Background Management options Prevention Answers to questions patients ask References 83 The ART program during a disaster Background Management options and priorities Prevention Answers to questions patients ask References 84 Using the wrong sperm or embryos in IVF Background Management options Prevention Answers to questions patients ask References

16 SECTION SEVEN: The male patient 85 Unexpected inability to produce a semen sample on the day of oocyte retrieval Background Management options Prevention Answers to questions patients ask References 86 The azoospermic patient Background Management options Answers to questions patients ask References 87 ART in men with Klinefelter syndrome Background Management options Answers to questions patients ask References 88 ART in men with 100% immotile sperm Background Management options Answers to questions patients ask References 89 Request for posthumous fatherhood with perimortem surgical sperm retrieval Background Management options Conclusion Answers to questions patients ask References 90 Retrograde ejaculation and anejaculation Background Management options Answers to questions patients ask References 91 Sperm retrieval in cancerous testes Background Management options Answers to questions patients ask References 92 Leukocytospermia and ART Background Management options Prevention Answers to questions patients ask References 93 The infertile male patient with a genetic cause Background Management options Prevention Answers to questions patients ask References 94 Y chromosome microdeletions and ART Background Effect of Y deletions on fertility and on couples’ choices Management options Answers to questions patients ask References 95 DNA fragmentation, antioxidants and ART Background Management options Answers to questions patients ask References

17 SECTION EIGHT: The ART pregnancy 96 Unexpected number or sex of babies after IVF Background Management options Prevention Answers to questions patients ask References 97 Suspected ectopic pregnancy after IVF Background Management options Prevention Answers to questions patients ask References 98 Cervical ectopic pregnancy after IVF Background Management options Answers to questions patients ask References 99 Heterotopic pregnancy after IVF Background Management options Prevention Answers to questions patients ask References 100 Multifetal pregnancy reduction after IVF Background Management options Prevention and legal aspects Answers to questions patients ask References 101 Multiple pregnancy after IVF: how to reduce preterm delivery Background Management options Prevention Answers to questions patients ask References 102 Hyperreactio luteinalis after IVF Background Management options Answers to questions patients ask References 103 Lactation by a commissioning mother in surrogacy Background Management options Answers to questions patients ask References 104 Children of ART Background Management options Prevention Answers to questions patients ask References

18 SECTION NINE: General and organizational issues 105 Managing physical symptoms during IVF Background Management options Prevention Answers to questions patients ask References 106 IVF when the prognosis is very poor or futile Background Management options Prevention Answers to questions patients ask References 107 Dealing with the emotional distress following failed IVF Background Management options Prevention Answers to questions patients ask References 108 Couple splitting while embryos are in storage Background Management options Prevention Answers to questions patients ask References 109 Unexpected drop in the IVF clinic pregnancy rate Background Management options Prevention Answers to questions patients ask References 110 Natural fertility after IVF Background Management options Answers to questions patients ask References 111 Training in ART * Background Management options Answers to questions patients ask References Notes 112 Keeping up to date in ART practice Background Management options Prevention Answers to questions patients ask References 113 Cross‐border reproductive care Background Management options Prevention Answers to questions patients ask References 114 Satellite and transport ART treatment Background Management options Answers to questions patients ask References 115 Social media use in ART Background Management options Facebook Instagram Twitter Audio and video platforms Content creation best practices Administration considerations Answers to questions clinicians ask References 116 Managing an ART unit as a profitable business Background Management options Answers to questions stakeholders commonly ask References

19 Index

20 End User License Agreement

List of Tables

1 Chapter 5 Table 5.1 Clinical interpretation of serological markers of hepatitis B virus...

2 Chapter 7 Table 7.1 FDA categories of risk for drugs in pregnancy [19]. Table 7.2 Safety profile of different drug classes in pregnancy [6,21,24,25,32,33... Table 7.3 Approved and off‐label drugs used in ART [19,21,34,36–38].

3 Chapter 8 Table 8.1 Risk factors for venous thromboembolism (VTE) [8]. Table 8.2 Enoxaparin dosing regimen for VTE prophylaxis [8].

4 Chapter 10 Table 10.1 Fertility preservation options according to gender and age at canc...

5 Chapter 13 Table 13.1 Obstetric complications associated with untreated overt maternal h... Table 13.2 Complications associated with uncontrolled maternal thyrotoxicosis... Table 13.3 Recommendations for thyroid function monitoring in pregnancy in th... Table 13.4 The conversion of carbimazole to propylthiouracil (PTU) treatment ...

6 Chapter 14 Table 14.1 Medications which cause hyperprolactinemia [10,11].

7 Chapter 23 Table 23.1 Vaccines and pregnancy.

8 Chapter 45Table 45.1 Live birth rate (with 95% CI) by oocyte number and age band, based...

9 Chapter 50Table 50.1 Table for target estradiol levels according to the day of stimulat...

10 Chapter 56Table 56.1 Incidence of vaginal bleeding after transvaginal ultrasound‐guided...Table 56.2 Incidence of intra‐abdominal bleeding after TVOR.

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