Ирина Якутенко - Вирус, который сломал планету. Почему SARS-CoV-2 такой особенный и что нам с ним делать

Все эти рассуждения основаны на идее, что после встречи с SARS-CoV-2 у людей сохраняется длительный иммунитет. Пока это неочевидно: точно мы знаем только то, что его хватает на несколько месяцев. Это было написано в середине лета — и уже в сентябре стало ясно, что этот сценарий в полной мере реализовался.

S. Duffy, «Why are RNA virus mutation rates so damn high?», PloS Biol. , vol. 16, no. 8, p. e3000003, Aug. 2018.

C. A. Suttle, «Viruses in the sea», Nature , vol. 437, no. 7057, pp. 356–361, Sep. 2005.

E. Braun and D. Sauter, «Furin-mediated protein processing in infectious diseases and cancer», Clin. Transl. Immunol. , vol. 8, no. 8, Jan. 2019.

K. Wang et al. , «SARS-CoV-2 invades host cells via a novel route: CD147-spike protein», bioRxiv , p. 2020.03.14.988345, Jan. 2020.

X. Wang et al. , «SARS-CoV-2 infects T lymphocytes through its spike protein-mediated membrane fusion», Cell. Mol. Immunol. , Apr. 2020.

H. Wang et al. , «SARS coronavirus entry into host cells through a novel clathrin- and caveolae-independent endocytic pathway», Cell Res. , vol. 18, no. 2, pp. 290–301, Feb. 2008.

M. Hoffmann et al. , «SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor», Cell , vol. 181, no. 2, pp. 271–280.e8, Apr. 2020.

J. Shang et al. , «Cell entry mechanisms of SARS-CoV-2», Proc. Natl. Acad. Sci. , vol. 117, no. 21, pp. 11727–11734, May 2020.

E. Braun and D. Sauter, «Furin-mediated protein processing in infectious diseases and cancer», Clin. Transl. Immunol. , vol. 8, no. 8, Jan. 2019.

K. Kuba, Y. Imai, and J. M. Penninger, «Multiple Functions of Angiotensin-Converting Enzyme 2 and Its Relevance in Cardiovascular Diseases», Circ. J. , vol. 77, no. 2, pp. 301–308, 2013.

T. Ivanova et al. , «Optimization of Substrate-Analogue Furin Inhibitors», ChemMedChem , vol. 12, no. 23, pp. 1953–1968, Dec. 2017.

Y. M. Bar-On, A. Flamholz, R. Phillips, and R. Milo, «SARS-CoV-2 (COVID-19) by the numbers», Elife , vol. 9, Apr. 2020.

K. B. Anand, S. Karade, S. Sen, and R. M. Gupta, «SARS-CoV-2: Camazotz’s Curse», Med. J. Armed Forces India , vol. 76, no. 2, pp. 136–141, Apr. 2020.

D. E. Gordon et al. , «A SARS-CoV-2 protein interaction map reveals targets for drug repurposing», Nature , vol. 583, no. 7816, pp. 459–468, Jul. 2020.

Y. Zhang et al. , «The ORF8 Protein of SARS-CoV-2 Mediates Immune Evasion through Potently Downregulating MHC–I», bioRxiv , p. 2020.05.24.111823, Jan. 2020.

A. B. Gussow, N. Auslander, G. Faure, Y. I. Wolf, F. Zhang, and E. V. Koonin, «Genomic determinants of pathogenicity in SARS-CoV-2 and other human coronaviruses», Proc. Natl. Acad. Sci. , vol. 117, no. 26, pp. 15193–15199, Jun. 2020.

M. J. Costello, R. M. May, and N. E. Stork, «Can We Name Earth’s Species Before They Go Extinct?» Science , vol. 339, no. 6118, pp. 413–416, Jan. 2013.

K. J. Locey and J. T. Lennon, «Scaling laws predict global microbial diversity», Proc. Natl. Acad. Sci. , vol. 113, no. 21, pp. 5970–5975, May 2016.

Y. Ikeda, «Feline Host Range of Canine parvovirus: Recent Emergence of New Antigenic Types in Cats», Emerg. Infect. Dis. , vol. 8, no. 4, pp. 341–346, Apr. 2002.

É. Leal et al. , «Regional adaptations and parallel mutations in Feline panleukopenia virus strains from China revealed by nearly-full length genome analysis», PLoS One , vol. 15, no. 1, p. e0227705, Jan. 2020.

K. E. Jones et al. , «Global trends in emerging infectious diseases», Nature , vol. 451, no. 7181, pp. 990–993, Feb. 2008.

Там же.

W. Li, «Bats Are Natural Reservoirs of SARS-Like Coronaviruses», Science (80-.). , vol. 310, no. 5748, pp. 676–679, Oct. 2005.

N. Wang et al. , «Serological Evidence of Bat SARS-Related Coronavirus Infection in Humans, China», Virol. Sin. , vol. 33, no. 1, pp. 104–107, Feb. 2018.

Y.-Y. Shen, L. Liang, Z.-H. Zhu, W.-P. Zhou, D. M. Irwin, and Y.-P. Zhang, «Adaptive evolution of energy metabolism genes and the origin of flight in bats», Proc. Natl. Acad. Sci. , vol. 107, no. 19, pp. 8666–8671, May 2010.

J. Xie et al. , «Dampened STING-Dependent Interferon Activation in Bats», Cell Host Microbe , vol. 23, no. 3, pp. 297–301.e4, Mar. 2018.

M. Ahn, J. Cui, A. T. Irving, and L.-F. Wang, «Unique Loss of the PYHIN Gene Family in Bats Amongst Mammals: Implications for Inflammasome Sensing», Sci. Rep. , vol. 6, no. 1, p. 21722, Feb. 2016.

E. Ryan, R. Hollingworth, and R. Grand, «Activation of the DNA Damage Response by RNA Viruses», Biomolecules , vol. 6, no. 1, p. 2, Jan. 2016.

C. E. Brook et al. , «Accelerated viral dynamics in bat cell lines, with implications for zoonotic emergence», Elife , vol. 9, Feb. 2020.

K. Xiao et al. , «Isolation of SARS-CoV-2-related coronavirus from Malayan pangolins», Nature , May 2020.

V. D. Menachery et al. , «A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence», Nat. Med. , vol. 21, no. 12, pp. 1508–1513, Dec. 2015.

M. F. Boni et al. , «Evolutionary origins of the SARS-CoV-2 sarbecovirus lineage responsible for the COVID-19 pandemic», Nat. Microbiol. , Jul. 2020.

D. Lim and B. Ehley, «Fauci says White House told NIH to cancel funding for bat virus study», Politico , 23-Jun-2020.

«NIH establishes Centers for Research in Emerging Infectious Diseases», National Institutes of Health , 27-Aug-2020.

A. W. H. Chin et al. , «Stability of SARS-CoV-2 in different environmental conditions», The Lancet Microbe , vol. 1, no. 1, p. e10, May 2020.

S. Li et al. , «COVID-19 receptor ACE2 is expressed in human conjunctival tissue, expecially in diseased conjunctival tissue», medRxiv , p. 2020.05.21.20109652, Jan. 2020.

N. van Doremalen et al. , «Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1», N. Engl. J. Med. , vol. 382, no. 16, pp. 1564–1567, Apr. 2020.