Бен Линч - Грязные гены. «Большая стирка» для вашей ДНК. Как изменить свою наследственность

20. Gallbladder issues a big pregnancy issue: Pusi, Thomas, Beuers, Ulrich. “Intrahepatic cholestasis of pregnancy,” Orphanet Journal of Rare Disease, 29 May 2007, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1891276/.

21. Methylation produces creatine: Bronsan, JT, Da Silva, RP, Bronsan, ME. “The metabolic burden of creatine synthesis,” Amino Acids, May 2011, https://www.ncbi.nlm.nih.gov/pubmed/21387089.

22. Poor methylation lead to muscular aches and pains: Onodi, Laszlo et al. “Creatine Treatment to Relieve Muscle Pain Caused by Thyroxine Replacement Therapy,” Pain Medicine, 12 April 2012, https://academic.oup.com/painmedicine/article-lookup/doi/10.1111/j.1526-4637.2012.01354.x.

23. Cardiovascular issues: Zhong, Jia, Agha, Golareh, Baccarelli Andrea A. “The Role of DNA Methylation in Cardiovascular Risk and Disease,” Circulation Research, 8 January 2016, http://circres.ahajournals.org/content/118/1/119.

24. To clear harmful chemicals and excess hormones, you need to methylate properly: Dawling S. et al. “Catechol-O-methyltransferase (COMT)-mediated metabolism of catechol estrogens: comparison of wildtype and variant COMT isoforms,” Cancer Research, 15 September 2001, https://www.ncbi.nlm.nih.gov/pubmed/11559542.

25. Methylation affects your ability to produce glutathione: Prudova, Anna et al. “S-adenosylmethionine stabilizes cystathionine β-synthase and modulates redox capacity,” Proceedings of the National Academy of Sciences of the United States of America, 9 March 2006, http://www.pnas.org/content/103/17/6489.full.

26. Methylation helps your immune system: Lei W. et al. “Abnormal DNA methylation in CD4+ T cells from patients with systemic lupus erythematosus, systemic sclerosis, and dermatomyositis,” Scandinavian Journal of Rheumatology, 2009, https://www.ncbi.nlm.nih.gov/pubmed/19444718.

27. Methylation helps prevent DNA errors when new cells are built: Bluont BC et al. “Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage,” Proceedings of the National Academy of Sciences of the United States of America, 1 April 1997, https://www.ncbi.nlm.nih.gov/pubmed/9096386.

28. Folic acid is unnatural and not useful until processed into a useful form: Bailey, Stephen W., Ayling, June E. “The extremely slow and variable activity of dihydrofolate reductase in human liver and its implications for high folic acid intake,” Proceedings of the National Academy of Sciences of the United States of America, 22 July 2009, http://www.pnas.org/content/106/36/15424.long.

29. Folic acid actually blocks methylation: Christensen, KE et al. “High folic acid consumption leads to pseudo-MTHFR deficiency, altered lipid metabolism, and liver injury in mice,” The American Jounral of Clinical Nutrition, March 2015, https://www.ncbi.nlm.nih.gov/pubmed/25733650.

30. Take folate instead of folic acid: Lynch, Ben. “Folic Acid and Pregnancy | Is Folic Acid the Right Choice?” You Tube, 7 September 2016, https://www.youtube.com/watch?v=tnVRv0zGsFY&t=603s.

31. In 1998, FDA required “enrichment” of foods: “Folate,” National Institutes of Health, Accessed April 2017, https://ods.od.nih.gov/factsheets/Folate-HealthProfessional/.

32. The wrong amount of exercise: Reynold, Gretchen. “How Exercise Changes Our DNA,” Well, 17 December 2014, https://well.blogs.nytimes.com/2014/12/17/how-exercise-changes-our-dna/?_r=1.

33. Poor Sleep: Kirkpatrick, Bailey. “The Epigenetics of Sleep: 3 Reasons to Catch More Zzz’s,” What is Epigenetics, 3 March 2015, http://www.whatisepigenetics.com/the-epigenetics-of-sleep-3-reasons-to-catch-more-zzzs/.

34. Methyl groups used faster under stress: Bing, Yuntao et al. “Glucocorticoid-induced S-Adenosylmethionine Enhances the Interferon Signaling Pathway by Restoring STAT1 Protein Methylation in Hepatitis B Virus-infected Cells,” The Journal of Biological Chemistry, 30 September 2014, http://www.jbc.org/content/289/47/32639.full.

3. Каков ваш генетический профиль?

35. COMT affects estrogen metabolism: Cussenot, Olivier. “Combination of Polymorphisms From Genes Related to Estrogen Metabolism and Risk of Prostate Cancers: The Hidden Face of Estrogens,” Journal of Clinical Oncology, August 2007, http://ascopubs.org/doi/full/10.1200/JCO.2007.11.0908.

4. Анкета № 1: каким генам необходима «чистка»?

5. MTHFR, или мастер метилирования

36. MTHFR SNP’s can lead to a decreased risk of colon cancer: Xie, SZ. et al. “Association between the MTHFR C677T polymorphism and risk of cancer: evidence from 446 case-control studies,” Tumour Biology, 17 June 2015, https://www.ncbi.nlm.nih.gov/pubmed/26081619.

37. If MTHFR is born dirty, it can have up to one hundred SNPS or even more: “MTHFR[all],” National Center for Biotechnology Information, U.S. National Library of Medicine, Accessed April 2017, https://www.ncbi.nlm.nih.gov/clinvar/?term=MTHFR[all].

38. Supports of healthy methylation: Wilcken, W. et al. “Geographical and ethnic variation of the 677C>T allele of 5,10 methylenetetrahydrofolate reductase (MTHFR): findings from over 7000 newborns from 16 areas world wide,” Journal of Medical Genetics, 2003, http://jmg.bmj.com/content/40/8/619.

39. Health Conditions Related to SNPs in Your MTHFR: “Genopedia: MTHFR,” Center for Disease Control and Prevention, Accessed April 2017, https://phgkb.cdc.gov/HuGENavigator/huGEPedia.do?firstQuery=MTHFR&geneID=4524&typeSubmit=GO&check=y&typeOption=gene&which=2&pubOrderType=pubD.

40. Cobalamin/B12 found in food: “Vitamin B 12,” Oregon State University Linus Pauling Institute Micronutrient Information Center, Accessed April 2017, http://lpi.oregonstate.edu/mic/vitamins/vitamin-B12#food-sources.

6. COMT. Внимательность и жизнерадостность, или спокойствие и отрешенность COMT

41. Catechols found in quercetin: “COMT Gene,” Genetic Home Reference, 11 April, 2017, https://ghr.nlm.nih.gov/gene/COMT#resources.

42. Dopamine quinone is associated with Parkinson’s disease and ADHD medications: Miyazak, Ikuko, Asanuma, Masato. “Approaches to Prevent Dopamine Quinone-Induced Neurotoxicity,” Neurochemical Research, 04 September 2008, http://link.springer.com/article/10.1007/s11064-008-9843-1.

43. Toxicity of Methylphenidate: Sadasivan, Shankar et al. “Methylphenidate Exposure Induces Dopamine Neuron Loss and Activation of Microglia in the Basal Ganglia of Mice,” PLOS One, 21 March 2012, http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0033693.

44. Toxicity of Methylphenidate: Espay, AJ. et al. “Methylphenidate for gait impairment in Parkinson disease,” American Academy of Neurology, 5 April 2011, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068005/.

45. Adderall can generate dopamine-quinone: German, Christopher L., Hanson, Glen R., Fleckenstein, Annette E., “Amphetamine and Methamphetamine Reduce Striatal Dopamine Transporter Function Without Concurrent Dopamine Transporter Relocalization,” Journal of Neurochemistry, 23 August 2012, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962019/.

46. Two common reasons for magnesium deficiency: Janett, S. et al. “Hypomagnesemia Induced by Long-Term Treatment with Proton-Pump Inhibitors,” Gastroentology Research & Practice, 4 May 2015, https://www.ncbi.nlm.nih.gov/pubmed/26064102.

47. Two common reasons for magnesium deficiency: Kynast-Gales, SA, Massey, LK. “Effect of caffeine on circadian excretion of urinary calcium and magnesium,” Journal of American College of Nutrition, October 1994, https://www.ncbi.nlm.nih.gov/pubmed/7836625.