Robin Cook - Seizure

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Seizure: краткое содержание, описание и аннотация

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Senator Ashley Butler is a quintessential Southern demagogue whose support of traditional American values includes a knee-jerk reaction against virtually all biotechnologies. When he's called to chair a subcommittee introducing legislation to ban new cloning technology, the senator views his political future in bold relief; and Dr. Daniel Lowell, inventor of the technique that will take stem cell research to the next level, sees a roadblock positioned before his biotech startup.
The two seemingly opposite personalities clash during the senate hearings, but the men have a common desire. Butler's hunger for political power far outstrips his concern for the unborn; and Lowell's pursuit of gargantuan personal wealth and celebrity overrides any considerations for patients' well-being. Further complicating the proceedings is the confidential news that Senator Butler has developed Parkinson's disease-leading the senator and the researcher into a Faustian pact. In a perilous attempt to prematurely harness Lowell's new technology, the therapy leaves the senator with the horrifying effects of temporal lobe epilepsy-seizures of the most bizarre order.
Torn from the headlines, Seizure is a cautionary tale for a time where biotechnology pulls us into a promising yet frightening new world.

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“Then we’d have to get them to differentiate into the proper nerve cells,” Stephanie added. “That will take another couple of weeks, or maybe a little less. The mouse cells were fine after only ten days.”

“So what would you guess, if all goes well?” Daniel asked. “Would a month work?”

“It’s theoretically possible,” Stephanie said. “It could be done, but we’d have to start almost immediately with the cellular work, like tomorrow! The problem with that idea is that we’d have to have human oocytes available, and we don’t.”

“Oh, jeez!” Daniel mumbled. He bit his lower lip and furrowed his brow. “I’m so accustomed to working with a surfeit of cow eggs that I forgot about the supply problem with human eggs.”

“It’s a major stumbling block,” Stephanie admitted. “Even in the best of circumstances where we already had a egg donor waiting in the wings, we’d need a month or so to stimulate her and retrieve them.”

“Well, perhaps our maverick infertility friends can help us in this regard as well. As a functioning infertility center, they’d surely have a few extra eggs available. Considering their unethical reputation, I bet with the right inducement we could talk them into providing us with what we will need.”

“It’s possible, I suppose, but then we’d be even more beholden to them. The more they do for us, the less easy it will be to wash our hands and leave like you so blithely suggested a moment ago.”

“But we don’t have a lot of choice. The alternative is giving up on CURE, HTSR, and all our blood, sweat, and tears.”

“It has to be your call. But for the record, it makes me feel uncomfortable to be obligated to the Wingate people in any form, knowing their history.”

Daniel nodded a few times as he mulled over the issues, sighed, and then turned back to the speakerphone. “Senator, there’s a chance we can have some treatment cells in a month. But I have to warn you that it’s going to require effort and a bit of luck, and we have to start immediately. You’ll have to be cooperative.”

“I will be as cooperative as a baby lamb. I’ve already started the process a month ago by making plans to arrive in Nassau on the twenty-third of March and to stay on the island for as much of the recess period as needed. I have even made a reservation for you. That’s how confident I was about your participation. It is important to have done this early, because it is high season in the Bahamas at this time of the year. We’ll be staying at the Atlantis resort, where I had the pleasure of staying last year with this plan in mind. It is a hotel complex sizable enough to provide adequate anonymity of coming and going without raising suspicions. They also have a casino, and as you might imagine, I do enjoy gambling when I am fortunate enough to have a few extra dollars in my pocket.”

Daniel exchanged glances with Stephanie. On the one hand, he was glad Ashley had made early reservations to help the project, but on the other hand, he was irritated at having been taken for granted.

“Will you be registered under your own name?” Stephanie questioned.

“Indeed I will,” Ashley said. “But I will be using an assumed name for my trip to the Wingate Clinic.”

“What about this clinic?” Daniel demanded. “I trust that you have looked into it as carefully as you have looked into my past.”

“Your trust is well placed. I think you will find the clinic well suited for our purposes, although the personnel less so. The purported head of the clinic is Dr. Spencer Wingate, who is something of a blowhard, although apparently well qualified in the field of infertility. He seems more interested in being an island socialite and looks forward to flying off to the continent to drum up business in the courts of Europe. The man in secondary command is Dr. Paul Saunders, and he runs the show on a day-to-day basis. He is a more complicated individual who sees himself as a world-class researcher despite his lack of appropriate training beyond clinical infertility. I’m confident both individuals will be accommodating if you merely appeal to their individual vanities. For them to have the prospect of working with someone with your credentials and stature is a once-in-a-lifetime opportunity.”

“You flatter me, Senator.”

Stephanie smiled at Daniel’s sarcasm.

“Only because it is well deserved,” Ashley said. “Besides, one should have faith in one’s doctor.”

“It would be my guess that doctors Wingate and Saunders will be more interested in money than my resume,” Daniel said.

“It is my thought that they will be interested in your resume to gain stature and to help them make money,” Ashley commented. “But their venal nature and their lack of research training is not a concern of ours, other than to be aware of it and to take advantage of it. It is their facility and equipment we are interested in.”

“I hope you realize that doing this procedure under these circumstances is not going to be cheap by any stretch of the imagination.”

“Nor would I want it to be cheap,” Ashley responded. “I want the expensive, high-quality, first-class version. Rest assured, I have access to more than sufficient funds to cover any expenses that impinge upon my political career. But I will expect your personal services to be pro bono. We are, after all, exchanging favors.”

“Agreed,” Daniel said. “But prior to rendering any services, Dr. D’Agostino and I will require you to sign a special release that we will draw up. This release will spell out the exact way that this affair originated as well as all the attendant risks involved, including the fact that we have never done the procedure on a human being.”

“As long as I can be assured of the confidentiality of this release, I will have no qualms about signing it. I can understand you would want it for your protection. I am absolutely certain I would want the very same thing if I were in your position, so there should be no problem whatsoever, provided it does not include anything unreasonable or inappropriate.”

“I can assure you it will be reasonable,” Daniel said. “Next, I’d like to encourage you to use your resources as you suggested to find out about access to the Shroud of Turin so we can get a sample.”

“I have already instructed Ms. Manning to initiate the appropriate meetings with the various prelates with whom I have had a working relationship. I will assume it will happen in the next few days. How big a sample would be required?”

“It can be extremely small,” Daniel said. “Merely a few fibers would be adequate, but it would have to be fibers coming from a section of the shroud containing a bloodstain.”

Ashley laughed. “Even an ignorant, nonscientist like myself would assume as much. The fact that you need only a small sample should help immeasurably. As I mentioned last night, I know there were such samples taken and then called back by the church.”

“We’d need them as soon as possible,” Daniel added.

“I understand completely the need for expeditiousness,” Ashley responded. “Is there anything else you require of me?”

“Yes,” Stephanie said. “We will need you to have a punch biopsy of your skin tomorrow morning. If there is a chance we can produce the curative cells in a month, we’ll need to take your biopsy back with us tomorrow when we return to Boston. Your private physician can arrange having the biopsy with a dermatologist, who can have a courier bring it over to us at the hotel. It will serve as a source of fibroblasts that we will grow in tissue culture.”

“I will see to it first thing in the morning.”

“I believe that is all for now,” Daniel said. He looked at Stephanie, and she nodded in agreement.

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