Robin Cook - Seizure

A gust of wind erupted and changed the drizzle momentarily from vertical to horizontal. Stephanie shivered as the moisture peppered her face. “It’s cold. Let’s get back to the hotel! There’s no sense standing here and getting soaked.”

As if waking from a trance, Daniel apologized and glanced around the plaza in front of the station. A taxi stand was off to one side, with several cabs conveniently waiting. Angling the umbrella into the wind, he urged Stephanie forward. Arriving at the first taxi in line, Daniel held the umbrella for Stephanie before climbing in himself.

“Four Seasons hotel,” Daniel said to the driver, who was watching his rearview mirror.

“Tonight was ironic as well as bizarre,” Stephanie said suddenly, as the cab pulled away. “The same day I hear a smidgen about your family from you, I hear the whole story from Senator Butler.”

“I find that more irritating than ironic,” Daniel said. “Hell, it’s an out-and-out violation of my privacy that he had me investigated by the FBI. It’s also appalling that the FBI would do it. I mean, I’m a private citizen under no suspicion of any crime. Such abuse smacks of the days of J. Edgar Hoover.”

“So everything Butler said about you is true?”

“Essentially, I suppose,” Daniel responded vaguely. “Listen, let’s talk about the senator’s offer.”

“I can tell you my reaction to it right off the top. I think it stinks!”

“You don’t see any positive aspects?”

“The only positive aspect I can see is that it has confirmed our impressions of the man as a quintessential demagogue. He’s also a detestable hypocrite. He’s against HTSR purely for political reasons, and he’s willing to ban it and its research despite its potential to save lives and relieve suffering. At the same time, he wants it for himself. That’s obscene and inexcusable, and we’re certainly not going to be a party to it.” Stephanie gave a short derisive laugh. “I’m sorry I gave my word to keep his illness a secret. This whole thing is a story the media would die for, and I’d love for them to have it.”

“We certainly can’t go to the media,” Daniel stated categorically. “And I don’t think we should be rash. I think Butler’s offer deserves consideration.”

A surprised Stephanie turned to look at Daniel. She tried to see his face in the dim light. “You’re not serious, are you?”

“Let’s list the knowns. We’re well acquainted with growing dopaminergic neurons from stem cells, so it’s not as if we’ll be floundering around in the dark in that regard.”

“We’ve done it with murine stem cells, not human cells.”

“The process is the same. Colleagues have already done it with human stem cells using the same methodology. Making the cells is not going to be a problem. Once we have the cells, we can follow the exact protocol we used for the mice. There’s no reason it wouldn’t work for a human. After all, every last mouse we’ve treated has done remarkably well.”

“Except for the ones that died.”

“We know why the ones that didn’t make it died. It was before we perfected the injection technique. All the mice that we injected properly have survived and have been cured. With a human volunteer, we would have available a stereotaxic device that doesn’t exist for rodents. That will make the injection more exact, infinitely easier, and hence safer. Besides, we wouldn’t do the injection ourselves. We’d find a neurosurgeon who’d be willing to lend a hand.”

“I can’t believe I’m hearing this,” Stephanie said. “It sounds like you’ve already talked yourself into doing this crazy, unethical experiment, and that’s what it would be: an uncontrolled, risky experiment on a single human subject. No matter what the outcome, it would be devoid of value, except possibly for Butler.”

“I don’t agree. By doing this procedure, we will save CURE and HTSR, meaning millions of people will ultimately benefit. It seems to me a minor compromise in ethics is a small up-front price to pay for an enormous back-end payoff.”

“But we’ll be doing exactly what Senator Butler accused the biotech industry of doing in his opening statement this morning: using ends to justify means. It would be unethical to experiment on Senator Butler, plain and simple.”

“Yeah, well, perhaps to some degree, but who are we putting at risk? It’s the villain! He’s the one asking for it. Worse yet, he’s conniving for it by extorting us with information he got by somehow coercing the FBI to do an illegal investigation.”

“That all may be true, but two wrongs don’t make a right, and it doesn’t absolve us of our complicity.”

“I think it would. We’ll make Butler sign a release, and we’ll put everything in the release, including the fact that we are fully aware that doing the procedure would be considered unethical by any research advisory board in this country, because it’s being done without an appropriately approved protocol. The release will state unequivocally that it was Butler’s idea to do the procedure and to do the procedure outside of the country. It will also state that he used extortion to get us to participate.”

“Do you think he’d sign such a release?”

“We won’t give him any choice. Either he signs it or he doesn’t get the benefit of HTSR. I’m comfortable with the idea that we’ll be doing the procedure in the Bahamas, so we won’t be violating any FDA rules, and we’ll have a rock-solid release in case we need it. The onus will be squarely on Butler’s shoulders.”

“Let me think about it for a few minutes.”

“Take your time, but I really think the moral weight favors our doing it. It would be different if we were forcing him in any way, shape, or form. But we’re not. It’s the other way around.”

“But it could be argued that he’s uninformed. He’s a politician, not a doctor. He doesn’t truly know the risks. He could die.”

“He’s not going to die,” Daniel said emphatically. “We’ll err on the conservative side, meaning the worse-case scenario is that we won’t give him enough cells to get his dopamine concentration high enough to get rid of all his symptoms. If that happens, he’ll be begging us to do it again, which will be easy, since we’ll maintain the treating cells in culture.”

“Let me mull it over.”

“Sure,” Daniel said.

They rode the rest of the way in silence. It wasn’t until they were going up in the hotel elevator that Stephanie spoke up: “Do you honestly think we would be able to find an appropriate place to do the procedure?”

“Butler spent a good deal of effort on all this,” Daniel said. “He wasn’t leaving anything to chance. Frankly, I’d be shocked if he didn’t have the clinic he mentioned investigated for appropriateness at the same time he had me investigated.”

“I suppose that’s possible. Actually, I remember reading about the Wingate Clinic about a year ago. It was a popular, unaffiliated infertility clinic out in Bookford, Massachusetts, before it moved under pressure to the Bahamas. It was quite a scandal.”

“I remember it too. It was run by a couple of maverick infertility guys. Their research department was doing unethical reproductive cloning experiments.”

“Unconscionable is a better description, like trying to get human fetuses to gestate in pigs. I remember they were also implicated in the disappearance of a couple of Harvard coed egg donors. The principals had to flee the country and barely managed to avoid extradition back to the States. All in all, it sounds like the absolute opposite of the kind of place and people we should get involved with.”

“We wouldn’t be getting involved with them. We’d do the procedure, wash our hands, and leave.”