Jeff Buick - Lethal Dose

Eight years.

She wiped the tears now, so she could see the twists and turns in the road as it descended from the top of the ridge toward Lake Superior. Eight years of her life with Marcon Pharmaceuticals, and this was where it was to end. Her research usurped by another group whose focus was on esthetics, not disease. She couldn’t believe Marcon had stooped to the levels of the other Big Pharma giants. The one reason she had brought her box of pens and her Ph.D. to Marcon was their commitment to discovering and developing new drugs that targeted disease. Under Roy Vagelos, the company’s CEO from 1985 to 1996, Marcon was the industry trendsetter in R amp;D. The company encouraged individual thinking that fostered new ideas and looked to lighting paths seldom traveled. It was the one by which all the Big Pharma companies set their benchmarks. Edward Pittman, the pharmaceutical analyst for the big money pension funds, used Marcon as a barometer for what was happening in the industry.

Marcon was the cornerstone of excellence. And that was why she had hung her shingle at Marcon rather than the hundred-odd other companies that had wooed her when she exited MIT with the ink still fresh on her doctorate. That, and the promises.

Her own research team, almost unlimited funding, the chance to set her own agenda; the offer was too good to turn down. And although her Phase I tests had gone well, her Phase II tests were average at best. Now they were pulling the rug out from under her.

The tears returned when she thought of the failed marriage and two other disastrous relationships, ruined by her reluctance to commit one hundred percent to anything or anyone outside the lab. She smashed her fist on the steering wheel, remembering the sadness in her husband’s eyes as he walked out the front door for the last time. She had let him go, choosing her career over his love. The road blurred as the tears flowed freely now. She accelerated into a curve and then hammered on the brakes as she realized she wasn’t going to make it. The rear end of the Taurus fishtailed and slammed into a gnarled basswood. The car threatened to veer into the trees for a second, then regained its grip on the road and came back under control. She slowed and sucked in a few deep breaths, aware of how close she had been to serious injury or death. Her hands were shaking, but she didn’t stop. There was one man who deserved a piece of her mind-and he was going to get it.

She reached Peterson’s Cottages on the distant edge of Ontonagon and pulled the battered rental up in front of Cedar Lodge, the largest of the guest cabins. She adjusted the rearview mirror so she could see her reflection. Her eyes, usually so clear and bright with sparkling hazel irises, were bloodshot. Framing her eyes were naturally thin, dark eyebrows. Her forehead, nose, and cheeks flowed flawlessly to her full lips, and when she smiled her teeth were white with few imperfections despite her never having had braces as a child. Her shoulder-length auburn hair was windblown but fell into place with a few flicks of her fingertips. She stared at her reflection for a few moments, taking in the toll of the last eight years.

She had been thirty when she first arrived at Marcon. Thirty and in demand by both pharmaceutical companies and a long line of single men. Her hair was longer then, past her shoulders, and her face leaner with no laugh lines. Her eyes were intelligent, and although she was strikingly attractive, they told the observer that this woman was no waitress at the local pub. She dressed well and carried herself with absolute confidence, something that scared some men and intrigued others. To say that she had been an interesting addition to the Marcon research was a gross understatement. Jennifer Pearce had been the primary topic at many lunch tables and over many a Budweiser at the bars near the research facility. But that was eight years ago, and this was now.

She opened the door and headed for the cabin without checking the damage on the rental. She knocked on the rough wood and waited. A half minute later, a tall man in his midsixties opened the door. He was dressed in a track suit and there was little fat on his frame. His hair was silver and his gaze steady and powerful. He didn’t smile when he saw her. He stepped aside, and she entered the rustic cabin. The aroma of freshly baked scones tinged the air.

She wasted no words. “What’s going to happen to my team?” she asked.

Sheldon Zachery, CEO of Marcon Pharmaceuticals, closed the door behind her, his face taking on a grim look. “It will be dismantled. We’ll try and find places for all your staff on other teams.”

“Then I quit, Sheldon,” she said. “Effective immediately.”

Zachery was thoughtful for a moment. “I wish you’d take some time, Jennifer, rethink things. You’ve invested a lot in Marcon and we’ve invested a lot in you.”

“I’ve given you the last eight years of my life,” she said, her voice rising. “In retrospect, I should have spent more time with my husband. Maybe I’d have kids, something to show I had a life once. My decision is final. I’m leaving.”

“You can’t take the research with you, Jennifer. It’s proprietary. It stays with us.”

She leaned close to one of the most influential and powerful men in the global pharmaceutical market. “What I have in my head stays there, Sheldon. That, I take with me. And it’s far more valuable than what’s on the discs in the lab.”

Zachery’s eyes narrowed. “What are you saying, Jennifer?”

“You figure it out, Sheldon. You’re the CEO. You’re the one with all the answers.”

“If you run to a competitor and deliver them proprietary goods, we’ll sue,” he said. “We’ll shut you and your new company down in record time.”

She smiled, even white teeth showing beneath her rekindled eyes. “Take your best shot, Sheldon, because what you’ve got in a court of law is squat. You’ve got Phase I and Phase II tests, but you don’t have a billion-dollar drug. Not by a long shot. That is going elsewhere, courtesy of your stupidity.”

His face took on color. “Are you threatening me?”

“You can take the truth as you wish, Sheldon. I know where I want to go with my research. You don’t. No one else does. For the past few months I’ve been biding my time, waiting to see whether Marcon would back a new approach to fighting Alzheimer’s. Now I know. Looks like keeping my trump card close to my chest was a good idea.”

“Maybe if you’d brought it out,” he said, “we would have seen things differently. Maybe the funding would have gone your way.”

“I doubt it,” she said. “I don’t think you understand. Marcon doesn’t think like it did when Vagelos was at the helm.” She turned to the door and opened it. A gust of cool spring air rushed in. “Have HR send my final check to my house. And don’t forget the vacation pay. You can keep whatever personal stuff is on my desk.”

She jumped into the Taurus and jammed it into gear. What a disaster. But in the back of her mind, she had suspected Zachery might hedge on her funding. Her group’s approach to the Alzheimer’s quandary was not novel, but more of the same, targeting the beta amyloid protein that was known to force healthy tissue aside and invade key spaces in the brain. But what Zachery and the other Marcon brass didn’t know was that she had isolated a new chemical in the sequence, one unknown and unnoticed in the hundreds of thousands of previous screened molecules by all the big pharmaceutical companies.

She had the key. She just had to prove it in clinical trials. And that knowledge was going with her when she left Marcon.

Evan Ziegler deplaned in Richmond, cursing the rain. It was the last day of April, but there was no warmth to the heavy mist. Just a gray day that chilled the bones and made driving ugly. He navigated the rental car through the sodden streets, past a group of school kids on their way home from classes, splashing in puddles and laughing when one of them slipped and fell, soaking his pants. Evan cracked a smile as a memory of Ben, drenched from a sudden downpour, came to mind. The smile faded as quickly as it had materialized.