Douglas Preston - Mount Dragon

“X-FLU,” Carson muttered. “That’s what Brandon-Smith said killed the chimp.”

“Correct,” Singer took a sip, exhaling contentedly.

“Forgive my bluntness,” said Carson, “but I’d really like to know what this project is all about. I still can’t understand why Mr. Scopes chose me out of—what—five thousand scientists? And why did I have to drop everything, get my ass out here on five minutes’ notice?”

Singer settled back. “Let me start at the beginning. Are you familiar with an animal called a bonobo?”

“No.”

“We used to call them pygmy chimpanzees until we realized they were a completely different species. Bonobos are even closer to human beings than the more common lowland chimps. They are more intelligent, form monogamous relationships, and share ninety-nine-point-two percent of our DNA. Most importantly, they get all our diseases. Except one.”

He paused, sipped his drink.

“They don’t get the flu. All other chimps, as well as gorillas and orangs, get the flu. But not the bonobo. This fact came to Brent’s attention about ten months ago. He sent us several bonobos, and we did some genetic sequencing. Let me show you what we discovered.”

Singer opened a notebook lying on the coffee table, moving aside a malachite egg to make room. Inside, the sheets of paper were covered with strings of letters in complex ladder-like arrangements.

“The bonobo has a gene that makes it immune to influenza. Not just one or two strains, but all sixty known varieties. We’ve named it the X-FLU gene.”

Carson examined the printout. It was a short gene, going only to several hundred base pairs.

“How does the gene work?” Carson asked.

Singer smiled. “We don’t really know. It would take years to figure it out. But Brent hypothesized that if we could insert this gene into human DNA, it would render humans immune to flu, as well. The initial in vitro tests we performed bore this out.”

“Interesting,” Carson replied.

“I’ll say. Take the gene out of the bonobo, and insert it into yourself. Presto, you never get the flu again.” Singer leaned forward and lowered his voice. “Guy, how much do you know about the flu?”

Carson hesitated. He actually knew quite a bit. But Singer didn’t seem the type who’d appreciate a braggart. “Not as much as I should. People are too complacent about it, for one thing.”

Singer nodded. “That’s right. People tend to think of it as a nuisance. But it’s not a nuisance. It’s one of the worst viral diseases in the world. Even today, a million people die annually from the flu. It remains one of the top ten causes of death in the United States. During flu season, one quarter of the population falls ill. And that’s in a good year. People forget that the swine flu epidemic of 1918 killed one person out of fifty worldwide. That was the worst pandemic in recorded history, worse than the Black Death. And it happened in this century . If it happened again today, we’d be almost as helpless now as we were then.”

“Truly virulent flu mutations can kill in hours,” Carson said. “But—”

“Just one moment, Guy. That word, mutation , is key. The serious pandemics occur when the flu virus undergoes significant mutation. It’s already happened three times this century, most recently with the Hong Kong flu in 1968. We’re overdue—we’re ripe— for another pandemic right now.”

“And because the coating of the viral particle keeps mutating,” Carson said, “there’s no permanent vaccine. A flu shot is just a cocktail of three or four strains, a guess on the part of epidemiologists as to what strain might be coming along in the next six months. Correct? They could guess wrong and you’d be just as sick.”

Singer smiled. “Very good, Guy. We’re well aware of the work you did with flu viruses at MIT. That’s part of the reason we chose you.”

He finished his drink with a short hard gulp. “One thing you may not have been aware of was that the world economy loses almost one trillion dollars a year in unrealized productivity to the flu.”

“I didn’t know that.”

“Here’s something else you may not know: the flu causes an estimated two hundred thousand birth defects annually. When a pregnant woman gets a fever above a hundred and four degrees, all kinds of developmental hell can break loose in the womb.”

He inhaled slowly. “Guy, we’re working on the last great medical advancement of the twentieth century. And now you’re a part of it. You see, with the X-FLU gene inserted into his body, a human being will be immune to all strains of the flu. Forever. What’s more, his children will inherit the immunity.”

Carson slowly put down his drink and looked at Singer.

“Jesus,” he said. “You mean, a gene therapy aimed at reproductive cells?”

“That’s right. We’re going to alter the germ cell line of the human race permanently. And you, Guy, are central to this effort.”

“But my work with influenza was just preliminary,” Carson said. “My main focus was elsewhere.”

“I know,” Singer replied. “Bear with me a moment longer. Our major obstacle has been getting the X-FLU gene into human DNA. It has to be done, of course, using a virus.”

Carson nodded. He knew that viruses worked by inserting their own DNA into a host’s DNA. That made viruses the ideal vector to exchange genes between distantly related species. As a result, most genetic engineering used viruses in this way.

“Here’s how it will work,” Singer continued. “We insert the X-FLU gene into a flu virus itself. Use the virus as a Trojan horse, if you will. Then we infect a person with that virus. As with any flu vaccine, the person will develop a mild case of influenza. Meanwhile, the virus has inserted the bonobo DNA into the person’s DNA. When he recovers, he’s got the X-FLU gene. And he’ll never get the flu again.”

“Gene therapy,” Carson said.

“Absolutely,” Singer replied. “It’s one of the hottest things around today. Gene therapies are promising to cure all kinds of genetic diseases. Like Tay-Sachs disease, PKU syndrome, hemophilia, you name it. Someday, anyone born with a genetic defect will be able to get the right gene and live a normal life. Only in this case, the ‘defect’ is susceptibility to the flu. And the change is inheritable .”

Singer mopped his brow. “I get pretty excited, talking about this stuff,” he said, grinning. “I never dreamed I could change the world when I was teaching at CalTech. X-FLU made me believe in God again, it really did.” He cleared his throat.

“We’re very close, Guy. But there’s one small problem. When we insert the X-FLU gene into the ordinary flu virus, it turns the ordinary virus virulent. Infinitely more virulent. And brutally contagious. Instead of being an innocuous messenger, the protein coat of the virus seems to mimic a hormone that stimulates the overproduction of cerebrospinal fluid. What you saw in the Fever Tank was the virus’s effect on a chimpanzee. We don’t quite know what it will do to a human being, but we know it won’t be pleasant.” He stood up and moved to a nearby window.

“Your job is to redesign the viral coat of the X-FLU ‘messenger’ virus. To render it harmless. To allow it to infect its human host without killing it, so that it can transport the X-FLU gene into human DNA.”

Carson opened his mouth to speak, then shut it abruptly. He suddenly understood why Scopes had plucked him out of the mass of GeneDyne talent. Until Fred Peck had set him to doing make-work, his specialty had been altering the protein shells that surround a virus. He knew that the protein coat of a virus could be changed or attenuated using heat, various enzymes, radiation, even through the growing of different strains. He’d done it all himself. There were many ways to neutralize a virus.