Frank Ryan - Virusphere

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A fascinating and long overdue examination of viruses – from what they are and what they do, to the vital role they have played in human history.What are viruses? Do they rely on genes, like all other forms of life? Do they follow the same patterns of evolution as plants and animals? Frank Ryan answers these questions and many more in a sweeping tour of illnesses caused by viruses. For example, the common cold, measles, chicken pox, herpes and mumps, rubella, as well as less familiar examples, such as rabies, ‘breakbone’ fever, haemorrhagic fevers like Ebola, and virus-induced cancers. Along the way, readers will learn about the behaviours and ultimate goals of viruses, gaining a deeper understanding of their importance in relation to the origins and the evolution of life, as well as they ways viruses have changed us at the most intimate level, to help make us quintessentially human.

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Copyright Contents Cover Title Page Copyright Dedication Epigraph Introduction 1. What Are Viruses? 2. Coughs and Sneezes Spread Diseases 3. A Plague Upon a Plague 4. Every Parent’s Nightmare 5. A Bug Versus a Virus 6. A Coincidental Paralysis 7. Deadly Viruses 8. An All-American Plague 9. Lurker Viruses 10. How Flu Viruses Reinvent Themselves 11. A Lesson from a Machiavellian Virus 12. The Mystery of Ebola 13. The Mercurial Nature of the Zika Virus 14. A Taste for the Liver 15. Warts and All 16. Lilliputian Giants 17. Are Viruses Alive? 18. Inspiring Terror – and Delight 19. The Ecology of the Oceans 20. The Virosphere 21. The Origins of the Placental Mammals 22. Viruses in the Origins of Life 23. The Fourth Domain? Bibliography and References Index About the Book About the Author Also by Frank Ryan About the Publisher

William Collins

An imprint of HarperCollins Publishers

1 London Bridge Street

London SE1 9GF

WilliamCollinsBooks.com

This eBook first published in Great Britain by William Collins in 2019

Copyright © Frank Ryan 2019

Cover photograph © Jacobs Stock Photography Ltd/Getty Images

Frank Ryan asserts the moral right to be identified as the author of this work.

A catalogue record for this book is available from the British Library.

All rights reserved under International and Pan-American Copyright Conventions. By payment of the required fees, you have been granted the non-exclusive, non-transferable right to access and read the text of this e-book on-screen. No part of this text may be reproduced, transmitted, down-loaded, decompiled, reverse engineered, or stored in or introduced into any information storage and retrieval system, in any form or by any means, whether electronic or mechanical, now known or hereinafter invented, without the express written permission of HarperCollins.

Source ISBN: 9780008296674

eBook Edition © March 2019 ISBN: 9780008296698

Version: 2020-02-28

Dedication Contents Cover Title Page Copyright Dedication Epigraph Introduction 1. What Are Viruses? 2. Coughs and Sneezes Spread Diseases 3. A Plague Upon a Plague 4. Every Parent’s Nightmare 5. A Bug Versus a Virus 6. A Coincidental Paralysis 7. Deadly Viruses 8. An All-American Plague 9. Lurker Viruses 10. How Flu Viruses Reinvent Themselves 11. A Lesson from a Machiavellian Virus 12. The Mystery of Ebola 13. The Mercurial Nature of the Zika Virus 14. A Taste for the Liver 15. Warts and All 16. Lilliputian Giants 17. Are Viruses Alive? 18. Inspiring Terror – and Delight 19. The Ecology of the Oceans 20. The Virosphere 21. The Origins of the Placental Mammals 22. Viruses in the Origins of Life 23. The Fourth Domain? Bibliography and References Index About the Book About the Author Also by Frank Ryan About the Publisher

I would like to thank my editors,

Myles Archibald and Hazel Eriksson,

and my agent, Jonathan Pegg,

for their support of my writing this book

Epigraph Contents Cover Title Page Copyright Dedication Epigraph Introduction 1. What Are Viruses? 2. Coughs and Sneezes Spread Diseases 3. A Plague Upon a Plague 4. Every Parent’s Nightmare 5. A Bug Versus a Virus 6. A Coincidental Paralysis 7. Deadly Viruses 8. An All-American Plague 9. Lurker Viruses 10. How Flu Viruses Reinvent Themselves 11. A Lesson from a Machiavellian Virus 12. The Mystery of Ebola 13. The Mercurial Nature of the Zika Virus 14. A Taste for the Liver 15. Warts and All 16. Lilliputian Giants 17. Are Viruses Alive? 18. Inspiring Terror – and Delight 19. The Ecology of the Oceans 20. The Virosphere 21. The Origins of the Placental Mammals 22. Viruses in the Origins of Life 23. The Fourth Domain? Bibliography and References Index About the Book About the Author Also by Frank Ryan About the Publisher

We all play hideous games with each other.

We step inside each other’s chalk circles.

Anthony Hopkins

Contents

Cover

Title Page

Copyright

Dedication

Epigraph

Introduction

1. What Are Viruses?

2. Coughs and Sneezes Spread Diseases

3. A Plague Upon a Plague

4. Every Parent’s Nightmare

5. A Bug Versus a Virus

6. A Coincidental Paralysis

7. Deadly Viruses

8. An All-American Plague

9. Lurker Viruses

10. How Flu Viruses Reinvent Themselves

11. A Lesson from a Machiavellian Virus

12. The Mystery of Ebola

13. The Mercurial Nature of the Zika Virus

14. A Taste for the Liver

15. Warts and All

16. Lilliputian Giants

17. Are Viruses Alive?

18. Inspiring Terror – and Delight

19. The Ecology of the Oceans

20. The Virosphere

21. The Origins of the Placental Mammals

22. Viruses in the Origins of Life

23. The Fourth Domain?

Bibliography and References

Index

About the Book

About the Author

Also by Frank Ryan

About the Publisher

Introduction Contents Cover Title Page Copyright Dedication Epigraph Introduction 1. What Are Viruses? 2. Coughs and Sneezes Spread Diseases 3. A Plague Upon a Plague 4. Every Parent’s Nightmare 5. A Bug Versus a Virus 6. A Coincidental Paralysis 7. Deadly Viruses 8. An All-American Plague 9. Lurker Viruses 10. How Flu Viruses Reinvent Themselves 11. A Lesson from a Machiavellian Virus 12. The Mystery of Ebola 13. The Mercurial Nature of the Zika Virus 14. A Taste for the Liver 15. Warts and All 16. Lilliputian Giants 17. Are Viruses Alive? 18. Inspiring Terror – and Delight 19. The Ecology of the Oceans 20. The Virosphere 21. The Origins of the Placental Mammals 22. Viruses in the Origins of Life 23. The Fourth Domain? Bibliography and References Index About the Book About the Author Also by Frank Ryan About the Publisher

What springs to your mind when you sit back and consider viruses? I am altogether aware that even if you come, as will many of my readers, from a non-scientific background, you will likely be uncertain as to the strange and ill-definable nature of viruses. Even among scientists, viruses are among the most enigmatic of the biological entities that are to be found on our precious blue-girdled planet. Certainly, there is a good deal of misinformation about them. You might, for example, be apt to confuse them with bacteria, a confusion that is not helped by the fact that we doctors caused this confusion in the first case by lumping two radically different entities together as the ‘microbes’ that are the root cause of infectious diseases.

Viruses frighten us. They elicit a primal fear of the unknown. They are capable of crashing through our natural barriers and defences, turning healthy cells into microscopic factories to produce exponential numbers of daughter viruses. These swarm through the bloodstream, drawing the attention of the immune system. This provokes our own white blood cells and other immune defences to become an aggressive reactionary force, fixated on annihilating the invaders, regardless of the devastation in their wake – indeed our very own immune system contributes to many of the familiar symptoms of the resultant illness, from runny noses to violent, bloody haemorrhages. In effect, every infection becomes a pitched battle that will determine the outcome for us, the host. As we come to know viruses better, we discover that they have also come to know us intimately, taking advantage of our very behaviour to facilitate their infectiousness and spread among us. All in all, that is rather scary. Especially so when we consider that some of those viruses include some of the most dangerous entities on the planet, entities eminently capable of making us very sick indeed – even killing us.

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