Protocols for High-Risk Pregnancies

Library of Congress Cataloging‐in‐Publication Data

Names: Queenan, John T., editor. | Spong, Catherine Y., editor. | Lockwood, Charles J., editor.

Title: Protocols for high‐risk pregnancies : an evidence‐based approach / edited by John T. Queenan, Catherine Y. Spong, Charles J. Lockwood.

Description: Seventh edition. | Hoboken, NJ : Wiley‐Blackwell, 2021. | Includes bibliographical references and index.

Identifiers: LCCN 2020024021 (print) | LCCN 2020024022 (ebook) | ISBN 9781119635260 (paperback) | ISBN 9781119635284 (adobe pdf) | ISBN 9781119635291 (epub)

Subjects: MESH: Pregnancy, High‐Risk | Pregnancy Complications | Evidence‐Based Medicine

Classification: LCC RG571 (print) | LCC RG571 (ebook) | NLM WQ 240 | DDC 618.3–dc23

LC record available at https://lccn.loc.gov/2020024021LC ebook record available at https://lccn.loc.gov/2020024022

Cover Design: Wiley

Cover Image: © Universal Images Group North America LLC/Alamy Stock Photo

The current acceleration in medical discoveries parallels Moore’s law for computer chips. In the 1950s, medical knowledge doubled every 50 years, by the 1980s it doubled every seven years, and now medical knowledge is estimated to double about every two months (Densen 2011). How can busy obstetricians keep pace? Through seven editions, Protocols for High‐Risk Pregnancies has helped address this exact challenge. Providing just‐in‐time content, its focus on protocols and guidelines helps organize medical thinking, avoid heuristic errors of omission and commission, and optimize maternal and fetal outcomes.

As with the prior six editions, we have once again assembled some of the world’s top obstetrical and medical experts. Concomitantly, the seventh edition adds a number of new features including protocols on opioid use, misuse and addiction in pregnancy and postpartum, noninvasive prenatal diagnosis of aneuploidy, periconceptional genetic screening, and expanded protocols on maternal valvular heart disease and cardiomyopathies; we have also added protocols on arboviruses including Zika, and malaria, to reflect new technologies, changing clinical disease patterns, and emerging global pathogens.

As in prior editions, our focus has been on conducting a comprehensive survey of recent relevant literature to extract the most current evidence‐based practices and then presenting them with concise, focused text and crystal‐clear clinical paradigms. In areas where there are reasonable clinical alternatives, where no single compelling randomized clinical trial or a clear metaanalytical preference is available, we have again asked the authors to use their best judgment to make recommendations.

We are deeply indebted to our common mentor, Dr John T. Queenan, who conceived of this text to help “clinicians in the trenches” and hope we have been faithful to his vision. We also appreciate the help of our editorial team at John Wiley & Sons, Deirdre Barry and Anupama Sreekanth.

Catherine Y. Spong, MD

Charles J. Lockwood, MD, MHCM

1 Densen P. Challenges and opportunities facing medical education. Trans Am Clin Climatol Assoc 2011; 122:48–58.

Christina M. AckermanDepartment of Obstetrics, Gynecology, and Reproductive Sciences, Division of Maternal Fetal Medicine, Yale School of Medicine, New Haven, CT, USA

Emily H. AdhikariDepartment of Obstetrics and Gynecology, Division of Maternal‐Fetal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA

Anne M. AmbíaDepartment of Obstetrics and Gynecology, Division of Maternal‐Fetal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA

Michal Fishel BartalDepartment of Obstetrics and Gynecology and Reproductive Sciences, The University of Texas Medical School at Houston, Houston, TX, USA

Michael A. BelfortDepartment of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX, USA

Vincenzo BerghellaDepartment of Obstetrics and Gynecology, Division of Maternal‐Fetal Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA

Richard BerkowitzDepartment of Obstetrics and Gynecology, Columbia University Medical Center, New York, USA

Bonnie L. BermasDivision of Rheumatic Diseases, University of Texas, Southwestern Medical Center, Dallas, TX, USA

Rupsa C. BoeligDepartment of Obstetrics and Gynecology, Division of Maternal‐Fetal Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA

Christian BrechotDepartment of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA

Haywood L. BrownDepartment of Obstetrics and Gynecology, University of South Florida, Tampa, FL, USA

Catalin S. BuhimschiDepartment of Obstetrics and Gynecology, University of Illinois College of Medicine at Chicago, Chicago, IL, USA

Irina A. BuhimschiDepartment of Obstetrics and Gynecology, University of Illinois College of Medicine at Chicago, Chicago, IL, USA

Elizabeth O. BuschurDepartment of Internal Medicine, Division of Endocrinology, Metabolism, and Diabetes, The Ohio State University Wexner Medical Center, Columbus, OH, USA

John ByrneDepartment of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX, USA

Joshua A. CopelDepartments of Obstetrics, Gynecology and Reproductive Sciences, and Pediatrics, Yale School of Medicine, New Haven, CT, USA

Mary E. D’AltonDepartment of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, New York Presbyterian Hospital, New York, USA

Jodi S. DasheDepartment of Obstetrics and Gynecology, Division of Maternal‐Fetal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA

Mara J. DinsmoorDepartment of Obstetrics and Gynecology, NorthShore University Health System, Evanston, IL, USA Department of Obstetrics and Gynecology, Pritzker School of Medicine, University of Chicago, Chicago, IL, USA

Kerry E. DruryDepartment of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC, USA

Elaine DuryeaMaternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX, USA

Sarah Rae EasterDepartments of Obstetrics and Gynecology, and Anesthesiology, Perioperative and Pain Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

Jerome J. FederspielDepartment of Obstetrics and Gynecology, Division of Maternal‐Fetal Medicine, Duke University Medical Center, Durham, NC, USA

Steven G. GabbeDepartment of Obstetrics and Gynecology, The Ohio State University Wexner Medical Center, Columbus, OH, USA Department of Obstetrics and Gynecology, The Ohio State University College of Medicine, Columbus, OH, USA

Henry L. GalanDepartment of Obstetrics and Gynecology, Division of Maternal‐Fetal Medicine, University of Colorado School of Medicine, Colorado Fetal Care Center, Aurora, CO, USA

Robert B. GhermanDivision of Maternal Fetal Medicine, WellSpan Health System, York, PA, USA

Afshan B. HameedDivision of Obstetrics and Gynecology, Irvine School of Medicine, University of California, Irvine, CA, USA