Poisonous Plants and Phytochemicals in Drug Discovery

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Focusing on phytochemicals and their potential for drug discovery, this book offers a comprehensive resource on poisonous plants and their applications in chemistry and in pharmacology.<br /><br /> <div id="_mcePaste" style="position: absolute; left: -10000px; top: 0px; width: 1px; height: 1px; overflow: hidden;">Provides a comprehensive resource on phytotoxins, covering historical perspectives, modern applications, and their potential in drug discovery</div> <div id="_mcePaste" style="position: absolute; left: -10000px; top: 0px; width: 1px; height: 1px; overflow: hidden;">– Covers the mechanisms, benefits, risks and management protocols of phytotoxins in a scientific laboratory and the usefulness in drug discovery</div> <div id="_mcePaste" style="position: absolute; left: -10000px; top: 0px; width: 1px; height: 1px; overflow: hidden;"> </div> <div id="_mcePaste" style="position: absolute; left: -10000px; top: 0px; width: 1px; height: 1px; overflow: hidden;">– Written and edited by leading researchers in phytochemistry, medicinal chemistry, analytical chemistry, toxicology, and more</div> <div id="_mcePaste" style="position: absolute; left: -10000px; top: 0px; width: 1px; height: 1px; overflow: hidden;"> </div> <div id="_mcePaste" style="position: absolute; left: -10000px; top: 0px; width: 1px; height: 1px; overflow: hidden;">– Presents chapters in a carefully designed, clear order, making it an ideal resource for the academic researcher or the industry professional at any stage in their career</div> <div> <ul> <li>Provides a comprehensive resource on phytotoxins, covering historical perspectives, modern applications, and their potential in drug discovery</li> <li>Covers the mechanisms, benefits, risks and management protocols of phytotoxins in a scientific laboratory and the usefulness in drug discovery</li> <li>Presents chapters in a carefully designed, clear order, making it an ideal resource for the academic researcher or the industry professional at any stage in their career</li> </ul> </div>

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Poisonous Plants and Phytochemicals in Drug Discovery

Edited by

Andrew G. Mtewa

Division of Biological Chemistry and Drug Discovery, WCAIR, School of Life Sciences, University of Dundee, Dundee, UK Chemistry Section, Malawi Institute of Technology, Malawi University of Science and Technology, Limbe, Malawi Pharmbiotechnology and Traditional Medicine Center (PHARMBIOTRAC), Department of Pharmacology, School of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda

Chukwuebuka Egbuna

Department of Biochemistry, Faculty of Natural Sciences, Chukwuemeka Odumegwu Ojukwu University, Uli, Anambra State, Nigeria Nutritional Biochemistry and Toxicology Unit, World Bank Africa Centre of Excellence, Centre for Public Health and Toxicological Research (ACE‐PUTOR), University of Port Harcourt, Port Harcourt, Rivers State, Nigeria

G.M. Narasimha Rao

Department of Botany, Andhra University, Visakhapatnam, Andhra Pradesh, India

This edition first published 2021 2021 John Wiley Sons Inc All rights - фото 1

This edition first published 2021

© 2021 John Wiley & Sons, Inc.

All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, except as permitted by law. Advice on how to obtain permission to reuse material from this title is available at http://www.wiley.com/go/permissions.

The right of Andrew G. Mtewa, Chukwuebuka Egbuna, and G.M. Narasimha Raoto be identified as the editors of the editorial material in this work has been asserted in accordance with law.

Registered Office John Wiley & Sons, Inc., 111 River Street, Hoboken, NJ 07030, USA

Editorial Office 111 River Street, Hoboken, NJ 07030, USA

For details of our global editorial offices, customer services, and more information about Wiley products visit us at www.wiley.com.

Wiley also publishes its books in a variety of electronic formats and by print‐on‐demand. Some content that appears in standard print versions of this book may not be available in other formats.

Limit of Liability/Disclaimer of Warranty In view of ongoing research, equipment modifications, changes in governmental regulations, and the constant flow of information relating to the use of experimental reagents, equipment, and devices, the reader is urged to review and evaluate the information provided in the package insert or instructions for each chemical, piece of equipment, reagent, or device for, among other things, any changes in the instructions or indication of usage and for added warnings and precautions. While the publisher and authors have used their best efforts in preparing this work, they make no representations or warranties with respect to the accuracy or completeness of the contents of this work and specifically disclaim all warranties, including without limitation any implied warranties of merchantability or fitness for a particular purpose. No warranty may be created or extended by sales representatives, written sales materials or promotional statements for this work. The fact that an organization, website, or product is referred to in this work as a citation and/or potential source of further information does not mean that the publisher and authors endorse the information or services the organization, website, or product may provide or recommendations it may make. This work is sold with the understanding that the publisher is not engaged in rendering professional services. The advice and strategies contained herein may not be suitable for your situation. You should consult with a specialist where appropriate. Further, readers should be aware that websites listed in this work may have changed or disappeared between when this work was written and when it is read. Neither the publisher nor authors shall be liable for any loss of profit or any other commercial damages, including but not limited to special, incidental, consequential, or other damages.

Library of Congress Cataloging‐in‐Publication Data

Names: Mtewa, Andrew G., 1985– editor. | Egbuna, Chukwuebuka, editor. | Rao, G. M. Narasimha, 1985– editor.

Title: Poisonous plants and phytochemicals in drug discovery / [edited by] Andrew G. Mtewa, Division of Biological Chemistry and Drug Discovery, WCAIR, School of Life Sciences, Dundee University, Dundee, Scotland, Chukwuebuka Egbuna, Department of Biochemistry, Faculty of Natural Sciences, Chukwuemeka Odumegwu Ojukwu University, Nigeria, G.M. Narasimha Rao, Department of botany, Andhra, Visakhapatnam, I, India.

Description: First edition. | Hoboken, NJ : Wiley, 2021. | Includes index.

Identifiers: LCCN 2020020090 (print) | LCCN 2020020091 (ebook) | ISBN 9781119650232 (cloth) | ISBN 9781119650270 (adobe pdf) | ISBN 9781119650256 (epub)

Subjects: LCSH: Botanical chemistry. | Poisonous plants–Toxicology. | Poisonous plants–Therapeutic use. | Phytotoxins. | Phytochemicals.

Classification: LCC QK865 .P65 2021 (print) | LCC QK865 (ebook) | DDC 572/.2–dc23

LC record available at https://lccn.loc.gov/2020020090LC ebook record available at https://lccn.loc.gov/2020020091

Cover Design: Wiley

Cover Image: © Anusorn Nakdee/Shutterstock

I dedicate this book to Thoko, Collins, Jed, and Michelle. You guys keep motivating.

Andrew

List of Contributors

Charles Oluwaseun AdetunjiApplied Microbiology, Biotechnology and Nanotechnology Laboratory, Department of Microbiology, Edo University Iyamho, Auchi, Edo State, Nigeria

Juliana Bunmi AdetunjiNutritional and Toxicological Research Laboratory, Department of Biochemistry, Osun State University, Osogbo, Nigeria

Shailaja AgrawalDepartment of Biotechnology, Harrisburg University of Science and Technology, Harrisburg, PA, USA

Muhammad AkramDepartment of Eastern Medicine, Government College University Faisalabad, Faisalabad, Pakistan

Amanjot AnnuDepartment of Pharmacology, School of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda

Halyna AntonyakDepartment of Ecology, Ivan Franko National University of Lviv, Lviv, Ukraine

Godwin AnywarDepartment of Plant Sciences, Microbiology & Biotechnology, College of Natural Sciences, Makerere University, Kampala, Uganda

Dharmandra BariaDepartment of Pharmaceutical Chemistry, A.R. College of Pharmacy, V.V.Nagar, Gujarat, India

Tamirat Bekele BeressaDepartment of Pharmacy, College of Medicine and Health Science, Ambo University, Ambo, Ethiopia Pharmbiotechnology and Traditional Medicine Center (PHARMBIOTRAC), Department of Pharmacology, School of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda Department of Pharmacology, School of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda

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