The Peripheral T-Cell Lymphomas

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The first text dedicated to peripheral T-cell lymphomas and their classification, diagnosis, and management  Peripheral T-cell lymphomas (PTCL) are a diverse group of lymphoid malignancies that develop from mature T cells and natural killer (NK) cells. PTCL represents 10-15% of all cases of non-Hodgkin lymphoma in the US, and up to 20-25% of cases in South America, Asia, and other regions around the world. The role of different etiologic factors and the variation of geographic distribution makes PTCL one of the most difficult types of cancer to understand and treat. 
The first book of its kind, 
 presents a far-reaching survey of this complex and rare group of blood cancers. Featuring contributions from thought-leaders concerned with all aspects of PTCL, this authoritative text covers biology, epidemiology, classification, approved and emerging drugs, molecular genetics, and more. Detailed clinical chapters address diagnosis, prognosis, and treatment of each of the major PTCL subtypes identified in the 2018 WHO Classification of Tumors of Hematopoietic and Lymphoid Tissues. This much-needed resource: 
Covers the biological basis, epidemiology, classification, and treatment of PTCL Discusses the future of the field, including global collaboration efforts and novel approaches to PCTL Explores the role of biologics in PTCL and autologous and allogeneic stem-cell transplantation Offers new insights on molecular pathogenesis, innovative therapeutics, and novel drug combinations Features contributions from the Chairs The T-Cell Lymphoma Forum: the world’s largest meeting focused on PTCL Reflecting the unique epidemiology and genetic diversity of the PTCL, 
 is an indispensable source of data, insight, and references for the medical community, particularly those working in oncology and hematology.

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The Peripheral T‐Cell Lymphomas

Edited by

Owen A. O’Connor, M.D., Ph.D.

American Cancer Society Research Professor

Professor of Medicine

Department of Medicine

Division of Hematology and Oncology

Program for TCell Lymphoma Research

Department of Microbiology, Immunology, and Cancer Research

University of Virginia Cancer Center, Charlottesville, VA, USA

Won Seog Kim

Sungkyunkwan University School of Medicine

Seoul, Korea

Pier Luigi Zinzani, M.D., Ph.D.

Professor of Hematology

Department of Medicine

Program for Lymphomas and Chronic Lymphocytic Leukemia

University of Bologna, Bologna Italy

This edition first published 2021 2021 John Wiley Sons Ltd All rights - фото 1

This edition first published 2021

© 2021 John Wiley & Sons Ltd

All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, except as permitted by law. Advice on how to obtain permission to reuse material from this title is available at http://www.wiley.com/go/permissions.

The right of Owen A. O’Connor, Won Seog Kim, and Pier Luigi Zinzani to be identified as the authors of the editorial material in this work has been asserted in accordance with law.

Registered Office(s) John Wiley & Sons, Inc., 111 River Street, Hoboken, NJ 07030, USA John Wiley & Sons Ltd, The Atrium, Southern Gate, Chichester, West Sussex, PO19 8SQ, UK

Editorial Office 9600 Garsington Road, Oxford, OX4 2DQ, UK

For details of our global editorial offices, customer services, and more information about Wiley products visit us at www.wiley.com. Wiley also publishes its books in a variety of electronic formats and by print‐on‐demand. Some content that appears in standard print versions of this book may not be available in other formats.

Limit of Liability/Disclaimer of Warranty The contents of this work are intended to further general scientific research, understanding, and discussion only and are not intended and should not be relied upon as recommending or promoting scientific method, diagnosis, or treatment by physicians for any particular patient. In view of ongoing research, equipment modifications, changes in governmental regulations, and the constant flow of information relating to the use of medicines, equipment, and devices, the reader is urged to review and evaluate the information provided in the package insert or instructions for each medicine, equipment, or device for, among other things, any changes in the instructions or indication of usage and for added warnings and precautions. While the publisher and authors have used their best efforts in preparing this work, they make no representations or warranties with respect to the accuracy or completeness of the contents of this work and specifically disclaim all warranties, including without limitation any implied warranties of merchantability or fitness for a particular purpose. No warranty may be created or extended by sales representatives, written sales materials or promotional statements for this work. The fact that an organization, website, or product is referred to in this work as a citation and/or potential source of further information does not mean that the publisher and authors endorse the information or services the organization, website, or product may provide or recommendations it may make. This work is sold with the understanding that the publisher is not engaged in rendering professional services. The advice and strategies contained herein may not be suitable for your situation. You should consult with a specialist where appropriate. Further, readers should be aware that websites listed in this work may have changed or disappeared between when this work was written and when it is read. Neither the publisher nor authors shall be liable for any loss of profit or any other commercial damages, including but not limited to special, incidental, consequential, or other damages.

Library of Congress Cataloging‐in‐Publication Data Names: O’Connor, Owen A., editor. | Kim, Won Seog, editor. | Zinzani, Luigi, editor. Title: The peripheral T‐cell lymphomas / edited by Owen A. O’Connor, Won Seog Kim, Pier Luigi Zinzani. Description: Hoboken, NJ : Wiley‐Blackwell, 2021. | Includes bibliographical references and index. Identifiers: LCCN 2020028451 (print) | LCCN 2020028452 (ebook) | ISBN 9781119671312 (hardback) | ISBN 9781119671329 (adobe pdf) | ISBN 9781119671367 (epub) Subjects: MESH: Lymphoma, T‐Cell, Peripheral Classification: LCC RC280.L9 (print) | LCC RC280.L9 (ebook) | NLM WH 525 | DDC 616.99/446–dc23 LC record available at https://lccn.loc.gov/2020028451LC ebook record available at https://lccn.loc.gov/2020028452

Cover Design: NA

Cover Images: Excellent backgrounds/Shutterstock

Contributors

Aadil AhmedDepartment of Hematology, Yale University School of Medicine, New Haven, CT, USA

Stephen M. AnsellDivision of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, USA

James O. ArmitageDivision of Oncology‐Hematology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA

N. Nora BennaniDivision of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, USA

Govind BhagatDivision of Hematopathology, Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA

Alessandro BroccoliIRCCS Azienda Ospedaliero‐Universitaria di Bologna Istituto di Ematologia “Seràgnoli”, Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale Università degli Studi, Bologna, Italia

HeeJin CheonDepartment of Medicine & Biochemistry and Molecular Genetics, Division of Hematology and Oncology, University of Virginia Cancer Center, Charlottesville, VA, USA

Monica CivalleroDepartment of Surgical, Medical and Dental Sciences Related to Transplant, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, Reggio Emilia, Italy

Paolo CorradiniFondazione IRCCS istituto Nazionale dei Tumori, Milano, Italy; and University of Milano, Italy

Sandeep DaveDuke Cancer Institute, Center for Genomic and Computational Biology, Duke University, Durham, NC, USA

Laurence de LevalInstitut de Pathologie, Centre Hospitalier Universitaire Vaudois et Université de Lausanne, Lausanne, Switzerland

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